Strain Name:
C57BL/6J-MtgxR1216Btlr/Mmmh
Stock Number:
039285-MU
Citation ID:
RRID:MMRRC_039285-MU
Other Names:
R1216 (G1), C57BL/6J-MtgxR1216Btlr
Major Collection:

Gene Information

Ppp2r2a
Name: protein phosphatase 2, regulatory subunit B, alpha
Synonyms: 2410004D02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 71978
VEGA: 14
HGNC: HGNC:9304
Homologene: 2035
Ints6
Name: integrator complex subunit 6
Synonyms: Notch2l, DICE1, 2900075H24Rik, Ddx26
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 18130
VEGA: 14
Homologene: 8121
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 73884
Homologene: 52868
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, B130044K16Rik, monocytic leukemia, qkf, querkopf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 54169
Homologene: 136480
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 360013
Homologene: 7977
Ranbp2
Name: RAN binding protein 2
Synonyms: A430087B05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19386
VEGA: 10
Homologene: 87808
Mtrex
Name: Mtr4 exosome RNA helicase
Synonyms: 2610528A15Rik, Skiv2l2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 72198
VEGA: 13
Homologene: 6257
Slc9a8
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 8
Synonyms: 1200006P13Rik, NHE8, 6430709P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 77031
Homologene: 75041
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C030046E11Rik, C130057E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226089
Homologene: 13806
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 58996
Homologene: 104145
Hnrnpm
Name: heterogeneous nuclear ribonucleoprotein M
Synonyms: Hnrpm, 2610023M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 76936
HGNC: HGNC:5046
Homologene: 4354
Plod1
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
Synonyms: lysyl hydroxylase 1, 2410042F05Rik, LH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 18822
HGNC: HGNC:9081
Homologene: 256
Prcp
Name: prolylcarboxypeptidase (angiotensinase C)
Synonyms: 2510048K03Rik, 2610104A14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 72461
HGNC: HGNC:9344
Homologene: 55867
Ncapg
Name: non-SMC condensin I complex, subunit G
Synonyms: 5730507H05Rik, MFT.M05.13, Hcapg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 54392
Homologene: 44071
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100317
Homologene: 11764
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, Sec3l1, 2810407P21Rik, SEC3, A730011E05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 69940
Homologene: 41241
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: BC002230, 6720454P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217827
VEGA: 12
Homologene: 41213
Spink4
Name: serine peptidase inhibitor, Kazal type 4
Synonyms: MPGC60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 20731
Homologene: 7954
Gpr152
Name: G protein-coupled receptor 152
Synonyms: A930009H15Rik, LOC269053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 269053
VEGA: 19
Homologene: 35474
Dppa4
Name: developmental pluripotency associated 4
Synonyms: 2410091M23Rik, ECAT15-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 73693
VEGA: 16
Homologene: 130462
Kcnj11
Name: potassium inwardly rectifying channel, subfamily J, member 11
Synonyms: Kir6.2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 16514
HGNC: HGNC:6257
Homologene: 441
Ghr
Name: growth hormone receptor
Synonyms: GHR/BP, GHBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 14600
HGNC: HGNC:4263
Homologene: 134
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: cAMP-GEFII, 5730402K07Rik, 1300003D15Rik, 6330581N18Rik, Epac2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56508
Homologene: 4451
Tecta
Name: tectorin alpha
Synonyms: Tctna, [a]-tectorin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 21683
Homologene: 3955
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Cul9
Name: cullin 9
Synonyms: 1810035I07Rik, Parc
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 78309
Homologene: 56696
Olfr73
Name: olfactory receptor 73
Synonyms: GA_x6K02T2Q125-49527073-49526132, mOR-EG, MOR174-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 117004
Homologene: 133889
Gm10985
Name: predicted gene 10985
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Fyb2
Name: FYN binding protein 2
Synonyms: 1700024P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 242594
Homologene: 52981
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 435864
Homologene: 129606
Rad21
Name: RAD21 cohesin complex component
Synonyms: SCC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 19357
VEGA: 15
HGNC: HGNC:9811
Homologene: 38161
Taar5
Name: trace amine-associated receptor 5
Synonyms: LOC215854
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215854
Homologene: 20850
Ttc7
Name: tetratricopeptide repeat domain 7
Synonyms: 1700007L07Rik, 1110035E02Rik, fsn, hea
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 225049
Homologene: 12515
Pcdhb7
Name: protocadherin beta 7
Synonyms: PcdhbG, Pcdhb4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93878
Homologene: 87123
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: A230044C21Rik, cpd2, Caps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 320405
Homologene: 23060
Pla2g6
Name: phospholipase A2, group VI
Synonyms: iPLA2, iPLA2beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 53357
HGNC: HGNC:9039
Homologene: 2635
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, SKIP, 4930544G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 77629
Homologene: 18172
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 320492
Homologene: 14194
Fgf12
Name: fibroblast growth factor 12
Synonyms: Fhf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14167
VEGA: 16
HGNC: HGNC:3668
Homologene: 10874
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: 0610010C24Rik, ASM3A, ASML3A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 57319
Homologene: 4886
B4galnt2
Name: beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms: Galgt2, Dlb-1, Dlb1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 14422
Homologene: 7329
Fam47e
Name: family with sequence similarity 47, member E
Synonyms: LOC384198, Gm1381
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384198
Homologene: 129958
Olfr1262
Name: olfactory receptor 1262
Synonyms: MOR234-1, GA_x6K02T2Q125-51434523-51435437
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258976
Homologene: 74064
Akr1c12
Name: aldo-keto reductase family 1, member C12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 622402
Homologene: 121208
Guca1a
Name: guanylate cyclase activator 1a (retina)
Synonyms: Guca1, mGCAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14913
VEGA: 17
HGNC: HGNC:4678
Homologene: 353
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,798,492 bp
  • G to A, chromosome 1 at 63,303,002 bp
  • A to T, chromosome 1 at 83,290,977 bp
  • C to A, chromosome 2 at 72,208,148 bp
  • T to C, chromosome 2 at 88,034,258 bp
  • T to A, chromosome 2 at 90,002,478 bp
  • T to C, chromosome 2 at 167,424,121 bp
  • A to C, chromosome 3 at 53,845,253 bp
  • T to G, chromosome 4 at 40,924,974 bp
  • G to A, chromosome 4 at 104,995,706 bp
  • T to C, chromosome 4 at 126,816,483 bp
  • A to T, chromosome 4 at 147,921,127 bp
  • G to T, chromosome 5 at 45,699,919 bp
  • A to G, chromosome 5 at 76,554,188 bp
  • A to G, chromosome 5 at 92,562,484 bp
  • G to T, chromosome 5 at 108,847,574 bp
  • A to G, chromosome 6 at 23,583,473 bp
  • C to A, chromosome 7 at 46,099,861 bp
  • A to G, chromosome 7 at 92,917,746 bp
  • A to T, chromosome 9 at 42,377,907 bp
  • A to T, chromosome 10 at 23,971,707 bp
  • T to G, chromosome 10 at 57,802,479 bp
  • T to C, chromosome 10 at 58,483,212 bp
  • A to G, chromosome 11 at 77,818,647 bp
  • A to G, chromosome 11 at 95,891,941 bp
  • T to C, chromosome 11 at 97,492,672 bp
  • G to A, chromosome 12 at 100,149,810 bp
  • T to C, chromosome 13 at 4,276,323 bp
  • G to A, chromosome 13 at 42,157,521 bp
  • A to G, chromosome 13 at 112,914,342 bp
  • T to A, chromosome 14 at 21,622,040 bp
  • A to T, chromosome 14 at 62,707,698 bp
  • G to T, chromosome 14 at 67,028,998 bp
  • A to G, chromosome 15 at 3,319,855 bp
  • T to C, chromosome 15 at 51,970,136 bp
  • T to C, chromosome 15 at 79,306,435 bp
  • A to T, chromosome 16 at 28,162,450 bp
  • T to C, chromosome 16 at 48,292,980 bp
  • T to C, chromosome 17 at 33,649,713 bp
  • C to G, chromosome 17 at 46,522,175 bp
  • A to G, chromosome 17 at 47,395,712 bp
  • C to T, chromosome 17 at 87,346,578 bp
  • C to T, chromosome 18 at 12,421,134 bp
  • A to T, chromosome 18 at 37,343,874 bp
  • T to A, chromosome 19 at 4,143,555 bp
  • G to T, chromosome 19 at 29,577,735 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1216 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039285-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.