Strain Name:
C57BL/6J-MtgxR1222Btlr/Mmmh
Stock Number:
039291-MU
Citation ID:
RRID:MMRRC_039291-MU
Other Names:
R1222 (G1), C57BL/6J-MtgxR1222Btlr
Major Collection:

Gene Information

Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms: 2610509C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 108147
HGNC: HGNC:794
Homologene: 2983
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 68420
Homologene: 23814
Ap2b1
Name: adaptor-related protein complex 2, beta 1 subunit
Synonyms: 1300012O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 71770
HGNC: HGNC:563
Homologene: 137384
Agrn
Name: agrin
Synonyms: NMF380, Agrin, nmf380
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Cux1
Name: cut-like homeobox 1
Synonyms: Cux, CDP, Cux-1, Cutl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13047
HGNC: HGNC:2557
Abl1
Name: c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms: c-Abl, E430008G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11350
HGNC: HGNC:76
Homologene: 3783
Xpo7
Name: exportin 7
Synonyms: Ranbp16, 4930506C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 65246
VEGA: 14
Homologene: 22857
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230082
Homologene: 41505
Rars
Name: arginyl-tRNA synthetase
Synonyms: 2610037E21Rik, 2610011N19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 104458
HGNC: HGNC:9870
Homologene: 68281
Gata2
Name: GATA binding protein 2
Synonyms: Gata-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 14461
HGNC: HGNC:4171
Homologene: 32030
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69116
Homologene: 10804
Kifc1
Name: kinesin family member C1
Synonyms: Tctex-7, Tctex-7A, Tctex7, Tctex7a, kinesin family c-terminal 5A, HSET, KNSL2, Kifc5a, Knsl2a, Gm4137
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 100502766
HGNC: HGNC:6389
Homologene: 83229
Erbb3
Name: erb-b2 receptor tyrosine kinase 3
Synonyms: Erbb-3, Erbb3r, HER3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13867
HGNC: HGNC:3431
Homologene: 20457
Car9
Name: carbonic anhydrase 9
Synonyms: CAIX, MN/CA9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99003
Homologene: 11710
Mctp2
Name: multiple C2 domains, transmembrane 2
Synonyms: LOC244049
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 244049
Homologene: 69254
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230676
Homologene: 49413
Plxna2
Name: plexin A2
Synonyms: OCT, Plxn2, 2810428A13Rik, PlexA2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Zmiz1
Name: zinc finger, MIZ-type containing 1
Synonyms: Rai17, Zimp10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 328365
Homologene: 10667
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: HZF-3, RNR-1, Nurr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Tdo2
Name: tryptophan 2,3-dioxygenase
Synonyms: TDO, TO, chky
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56720
Homologene: 4132
Reln
Name: reelin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 19699
HGNC: HGNC:9957
Homologene: 3699
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Plekhg4
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 4
Synonyms: 4931414L13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102075
Homologene: 18516
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Olfr395
Name: olfactory receptor 395
Synonyms: GA_x6K02T2P1NL-4062605-4061667, MOR135-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 259007
Trim45
Name: tripartite motif-containing 45
Synonyms: 4921530N01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229644
Homologene: 11865
Slc4a5
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5
Synonyms: C330016K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232156
Homologene: 31125
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 629499
Homologene: 51864
Abca9
Name: ATP-binding cassette, sub-family A (ABC1), member 9
Synonyms: D630040K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 217262
HGNC: HGNC:39
Homologene: 33332
Izumo3
Name: IZUMO family member 3
Synonyms: 1700011H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69314
Homologene: 122080
Trim43a
Name: tripartite motif-containing 43A
Synonyms: Gm6021
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 547109
Homologene: 105432
Serpinb1c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1c
Synonyms: EIC, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 380839
HGNC: HGNC:3311
Homologene: 137840
Taar4
Name: trace amine-associated receptor 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 209513
Homologene: 45509
Mylk
Name: myosin, light polypeptide kinase
Synonyms: telokin, Mlck, MLCK210, MLCK108, 9530072E15Rik, A930019C19Rik, nmMlck
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Olfr1115
Name: olfactory receptor 1115
Synonyms: MOR273-4P, GA_x6K02T2Q125-48736906-48737886, MOR273-4P, MOR264-20, Olfr1530-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258294
Homologene: 27114
Rrs1
Name: ribosome biogenesis regulator 1
Synonyms: 5730466A07Rik, D1Ertd701e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59014
Homologene: 41014
AC165412.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Olfr493
Name: olfactory receptor 493
Synonyms: GA_x6K02T2PBJ9-10676998-10676054, MOR204-35
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258307
Homologene: 17188
Fam13a
Name: family with sequence similarity 13, member A
Synonyms: D430015B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58909
Homologene: 135847
Dlgap3
Name: DLG associated protein 3
Synonyms: PSD-95/SAP90-binding protein 3, SAP90/PSD 95 associated protein 3, DAP3, Sapap3, Prpl8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242667
Homologene: 18276
Selplg
Name: selectin, platelet (p-selectin) ligand
Synonyms: Psgl-1, Psgl1, CD162
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 20345
Homologene: 2261
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: AQ27, Gpr103
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229214
Homologene: 18865
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13086
Homologene: 85917
Vat1l
Name: vesicle amine transport protein 1 like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270097
Homologene: 10855
Olfr77
Name: olfactory receptor 77
Synonyms: 18A, MOR143-1, GA_x6K02T2PVTD-13660026-13660964
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258336
Homologene: 133688
Tpp1
Name: tripeptidyl peptidase I
Synonyms: Cln2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12751
HGNC: HGNC:2073
Homologene: 335
Gm2663
Name: predicted gene 2663
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100040208
Homologene: 117995
Gm5096
Name: predicted gene 5096
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 329008
VEGA: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 9,545,855 bp
  • T to A, chromosome 1 at 20,567,456 bp
  • C to T, chromosome 1 at 71,559,279 bp
  • A to G, chromosome 1 at 194,800,649 bp
  • T to C, chromosome 2 at 31,800,994 bp
  • A to T, chromosome 2 at 57,108,324 bp
  • G to T, chromosome 2 at 87,252,422 bp
  • C to A, chromosome 2 at 104,777,431 bp
  • G to A, chromosome 2 at 157,241,854 bp
  • C to A, chromosome 3 at 36,180,095 bp
  • T to A, chromosome 3 at 59,877,261 bp
  • A to G, chromosome 3 at 81,961,468 bp
  • G to T, chromosome 3 at 100,927,298 bp
  • A to T, chromosome 4 at 41,120,760 bp
  • G to T, chromosome 4 at 43,512,439 bp
  • T to A, chromosome 4 at 92,145,047 bp
  • A to T, chromosome 4 at 118,405,459 bp
  • A to T, chromosome 4 at 127,194,613 bp
  • T to C, chromosome 4 at 139,388,471 bp
  • C to A, chromosome 4 at 156,177,385 bp
  • T to A, chromosome 5 at 21,986,955 bp
  • C to T, chromosome 5 at 113,819,373 bp
  • T to A, chromosome 5 at 114,800,763 bp
  • C to T, chromosome 5 at 136,275,149 bp
  • T to C, chromosome 6 at 40,996,041 bp
  • C to T, chromosome 6 at 58,935,722 bp
  • A to G, chromosome 6 at 83,280,132 bp
  • G to A, chromosome 6 at 88,200,341 bp
  • T to C, chromosome 7 at 26,308,588 bp
  • T to A, chromosome 7 at 72,259,139 bp
  • T to C, chromosome 7 at 105,746,741 bp
  • T to A, chromosome 7 at 108,346,106 bp
  • T to C, chromosome 7 at 120,090,676 bp
  • G to A, chromosome 8 at 105,379,110 bp
  • T to C, chromosome 8 at 114,282,361 bp
  • T to C, chromosome 9 at 7,505,681 bp
  • G to A, chromosome 9 at 19,921,048 bp
  • A to T, chromosome 9 at 88,843,078 bp
  • C to T, chromosome 10 at 23,961,332 bp
  • A to C, chromosome 10 at 128,571,665 bp
  • A to T, chromosome 11 at 35,809,740 bp
  • A to T, chromosome 11 at 73,907,414 bp
  • T to C, chromosome 11 at 83,346,738 bp
  • T to C, chromosome 11 at 110,145,064 bp
  • T to A, chromosome 13 at 32,896,951 bp
  • T to C, chromosome 14 at 25,658,096 bp
  • T to C, chromosome 14 at 55,863,541 bp
  • A to T, chromosome 14 at 70,667,084 bp
  • T to C, chromosome 16 at 34,860,652 bp
  • G to A, chromosome 17 at 33,884,711 bp
  • A to G, chromosome 18 at 87,757,334 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1222 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039291-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.