Strain Name:
C57BL/6J-MtgxR1223Btlr/Mmmh
Stock Number:
039292-MU
Citation ID:
RRID:MMRRC_039292-MU
Other Names:
R1223 (G1), C57BL/6J-MtgxR1223Btlr
Major Collection:

Gene Information

Ppp1cc
Name: protein phosphatase 1 catalytic subunit gamma
Synonyms: PP1C gamma 1, PP1C gamma 2, PP1, PP1C gamma
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 19047
HGNC: HGNC:9283
Homologene: 135423
Adcy9
Name: adenylate cyclase 9
Synonyms: ACtp10, D16Wsu65e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Usp34
Name: ubiquitin specific peptidase 34
Synonyms: Murr2, A530081C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17847
Homologene: 40978
Ddx47
Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
Synonyms: 4930588A18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 67755
Homologene: 6092
Arl10
Name: ADP-ribosylation factor-like 10
Synonyms: Arm1, ARL10, Arl10a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 56795
Homologene: 10550
Pip4k2b
Name: phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Synonyms: PI5P4Kbeta, c11, Pip5k2b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 108083
HGNC: HGNC:8998
Homologene: 2634
Osr1
Name: odd-skipped related transcription factor 1
Synonyms: Odd1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 23967
VEGA: 12
HGNC: HGNC:8111
Homologene: 8035
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, 4921513O20Rik, D630001M17Rik, 9330188B09Rik, LOC381026
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 66725
Homologene: 18982
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 2810040A01Rik, 5630401D06Rik, 2810013C04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Ten-m3, Odz3, 2610100B16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 23965
Homologene: 22673
D430042O09Rik
Name: RIKEN cDNA D430042O09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233865
Homologene: 45841
Cd180
Name: CD180 antigen
Synonyms: RP105, Ly78
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17079
HGNC: HGNC:6726
Homologene: 4077
Sptbn5
Name: spectrin beta, non-erythrocytic 5
Synonyms: Spnb5, EG640524
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 640524
Homologene: 41150
Mrgprb1
Name: MAS-related GPR, member B1
Synonyms: MrgB1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233231
Homologene: 24986
Ephx4
Name: epoxide hydrolase 4
Synonyms: LOC384214, Abhd7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 384214
Homologene: 62402
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 74055
Homologene: 9478
Commd3
Name: COMM domain containing 3
Synonyms: D2Ertd542e, Bup
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12238
Homologene: 15693
Rnh1
Name: ribonuclease/angiogenin inhibitor 1
Synonyms: RNH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 107702
Homologene: 2204
Dgkz
Name: diacylglycerol kinase zeta
Synonyms: mDGK[z], E130307B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 104418
HGNC: HGNC:2857
Homologene: 37831
Mybphl
Name: myosin binding protein H-like
Synonyms: 1110037P11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 68753
Homologene: 19221
Sec16b
Name: SEC16 homolog B (S. cerevisiae)
Synonyms: Lztr2, Rgpr-p117, Rgpr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 89867
Homologene: 13227
Rad51ap1
Name: RAD51 associated protein 1
Synonyms: RAB22, 2510006L10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 19362
Homologene: 48436
Laptm5
Name: lysosomal-associated protein transmembrane 5
Synonyms: E3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16792
Homologene: 4922
Serpinb3a
Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
Synonyms: Sqn5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20248
Homologene: 76659
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 620913
Homologene: 83188
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 626578
Homologene: 128731
Slc18a1
Name: solute carrier family 18 (vesicular monoamine), member 1
Synonyms: 4832416I10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 110877
Homologene: 20664
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: TR2, Gpr71, T1r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 83770
Homologene: 75323
Thoc5
Name: THO complex 5
Synonyms: Fmip, PK1.3, A430085L24Rik, 1700060C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 107829
Homologene: 37836
Olfr1154
Name: olfactory receptor 1154
Synonyms: GA_x6K02T2Q125-49403456-49402524, MOR173-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258641
Homologene: 74192
Tmprss11e
Name: transmembrane protease, serine 11e
Synonyms: DESC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 243084
Homologene: 8543
Ces3a
Name: carboxylesterase 3A
Synonyms: Es-male carboxylesterase, Es31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 382053
HGNC: HGNC:1865
Homologene: 84407
Tcirg1
Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3
Synonyms: OC-116, Atp6i, V-ATPase a3, TIRC7, ATP6a3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 27060
Homologene: 4392
Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
Synonyms: sterol 12-alpha-hydrolase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13124
HGNC: HGNC:2653
Homologene: 3233
Olfr676
Name: olfactory receptor 676
Synonyms: MOR32-1, GA_x6K02T2PBJ9-7664016-7664969
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259099
Homologene: 64955
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: 2300001H05Rik, CYSLT2R, Cyslt2, CysLT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 70086
VEGA: 14
Homologene: 10688
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 107,047,552 bp
  • T to A, chromosome 1 at 157,535,839 bp
  • T to C, chromosome 2 at 18,674,968 bp
  • G to A, chromosome 2 at 87,902,819 bp
  • T to C, chromosome 2 at 91,939,315 bp
  • T to A, chromosome 2 at 120,072,044 bp
  • A to G, chromosome 3 at 108,375,196 bp
  • A to G, chromosome 4 at 130,926,734 bp
  • A to T, chromosome 4 at 139,660,204 bp
  • T to G, chromosome 5 at 86,719,893 bp
  • A to C, chromosome 5 at 105,219,001 bp
  • C to A, chromosome 5 at 107,403,787 bp
  • A to G, chromosome 5 at 122,168,214 bp
  • A to G, chromosome 6 at 126,927,703 bp
  • G to A, chromosome 6 at 135,012,314 bp
  • A to G, chromosome 7 at 48,447,687 bp
  • T to C, chromosome 7 at 73,484,517 bp
  • A to T, chromosome 7 at 105,035,566 bp
  • T to A, chromosome 7 at 125,760,423 bp
  • A to G, chromosome 7 at 141,163,207 bp
  • A to T, chromosome 8 at 48,240,396 bp
  • G to A, chromosome 8 at 69,040,232 bp
  • A to T, chromosome 8 at 105,058,029 bp
  • A to G, chromosome 9 at 121,915,004 bp
  • A to G, chromosome 11 at 4,921,922 bp
  • A to G, chromosome 11 at 23,446,464 bp
  • T to A, chromosome 11 at 48,907,276 bp
  • G to A, chromosome 11 at 97,718,894 bp
  • C to T, chromosome 12 at 9,579,699 bp
  • A to G, chromosome 13 at 54,578,931 bp
  • A to T, chromosome 13 at 102,706,222 bp
  • A to T, chromosome 14 at 73,030,099 bp
  • A to G, chromosome 15 at 91,673,635 bp
  • A to T, chromosome 16 at 4,298,748 bp
  • G to T, chromosome 18 at 20,573,493 bp
  • T to C, chromosome 19 at 3,898,733 bp
  • C to T, chromosome 19 at 38,702,013 bp
  • T to C, chromosome 19 at 38,767,226 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1223 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039292-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.