Strain Name:
C57BL/6J-MtgxR1241Btlr/Mmmh
Stock Number:
039308-MU
Citation ID:
RRID:MMRRC_039308-MU
Other Names:
R1241 (G1), C57BL/6J-MtgxR1241Btlr
Major Collection:

Gene Information

Ntsr1
Name: neurotensin receptor 1
Synonyms: NTR-1, Ntsr1, NT-1R, NTR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C130076O07Rik, Bravo, C030017F07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Jarid2
Name: jumonji, AT rich interactive domain 2
Synonyms: Jmj, jumonji
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72313
Homologene: 103956
Nbea
Name: neurobeachin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Suclg2
Name: succinate-Coenzyme A ligase, GDP-forming, beta subunit
Synonyms: D6Wsu120e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 20917
Homologene: 2854
Ambra1
Name: autophagy/beclin 1 regulator 1
Synonyms: D030051N19Rik, 2310079H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228361
Homologene: 18204
Vasp
Name: vasodilator-stimulated phosphoprotein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22323
Homologene: 7592
Flnb
Name: filamin, beta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Srebf2
Name: sterol regulatory element binding factor 2
Synonyms: nuc, lop13, SREBP-2, bHLHd2, SREBP2gc, SREBP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 20788
VEGA: 15
Homologene: 20966
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Knl1
Name: kinetochore scaffold 1
Synonyms: 2310043D08Rik, Casc5, 5730505K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76464
Homologene: 44890
Kif5b
Name: kinesin family member 5B
Synonyms: Khc, kinesin heavy chain
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16573
HGNC: HGNC:6324
Homologene: 55829
Fkbp15
Name: FK506 binding protein 15
Synonyms: FKBP133, C430014M02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 338355
Homologene: 28743
Huwe1
Name: HECT, UBA and WWE domain containing 1
Synonyms: LOC382250, 5430439H10Rik, Ib772, C430014N20Rik, Ureb1, Mule, Arf-bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 59026
Homologene: 45994
Ap5z1
Name: adaptor-related protein complex 5, zeta 1 subunit
Synonyms: C330006K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231855
Homologene: 18213
Nfix
Name: nuclear factor I/X
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 18032
HGNC: HGNC:7788
Homologene: 1872
Atp6v1b1
Name: ATPase, H+ transporting, lysosomal V1 subunit B1
Synonyms: D630039P21Rik, D630030L16Rik, Atp6b1, Vpp-3, lysosomal 56/58kDa, Vpp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 110935
HGNC: HGNC:853
Homologene: 68198
Sidt2
Name: SID1 transmembrane family, member 2
Synonyms: CGI-40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214597
Homologene: 22943
Ttc7b
Name: tetratricopeptide repeat domain 7B
Synonyms: Ttc7l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104718
VEGA: 12
Homologene: 14675
Snx27
Name: sorting nexin family member 27
Synonyms: 5730552M22Rik, ESTM47
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 76742
Homologene: 12797
Myo15
Name: myosin XV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Egln3
Name: egl-9 family hypoxia-inducible factor 3
Synonyms: SM-20, Phd3, Hif-p4h-3, 2610021G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 112407
Homologene: 32531
Dennd5b
Name: DENN/MADD domain containing 5B
Synonyms: D030011O10Rik, 9330160C06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320560
Homologene: 44911
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: mdm, 2310036G12Rik, D830007G01Rik, shru, L56, 2310074I15Rik, 2310057K23Rik, connectin, D330041I19Rik, 1100001C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233651
Homologene: 2771
Ctsb
Name: cathepsin B
Synonyms: CB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13030
VEGA: 14
HGNC: HGNC:2527
Homologene: 37550
Mlxipl
Name: MLX interacting protein-like
Synonyms: ChREBP, Wbscr14, bHLHd14, WS-bHLH
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 58805
Homologene: 32507
Gcnt3
Name: glucosaminyl (N-acetyl) transferase 3, mucin type
Synonyms: 2010013H22Rik, 2210021I22Rik, 2210401J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 72077
VEGA: 9
HGNC: HGNC:4205
Homologene: 20993
Flt1
Name: FMS-like tyrosine kinase 1
Synonyms: Flt-1, VEGFR-1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 14254
HGNC: HGNC:3763
Homologene: 134179
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: Nalp2, E330007A02Rik, PYPAF2, Nbs1, Pan1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232827
Homologene: 56789
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 211223
Homologene: 129606
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Mll2, Wbp7, 2610014H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 75410
Homologene: 22838
Gm11437
Name: predicted gene 11437
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 628813
Homologene: 82346
Tdrd1
Name: tudor domain containing 1
Synonyms: MTR-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 83561
Homologene: 12850
Myo1a
Name: myosin IA
Synonyms: Myhl, brush border myosin 1, BBM-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: 2700071E21Rik, ISOT3, IsoT-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72607
Homologene: 68372
Cd209e
Name: CD209e antigen
Synonyms: mSIGNR4, SIGNR4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170780
HGNC: HGNC:1641
Homologene: 128353
Cdhr4
Name: cadherin-related family member 4
Synonyms: Cdh29, D330022A01Rik, 1700021K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 69398
Homologene: 82362
Ctsk
Name: cathepsin K
Synonyms: Cat K, catK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13038
HGNC: HGNC:2536
Homologene: 68053
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Olfr982
Name: olfactory receptor 982
Synonyms: MOR223-4, GA_x6K02T2PVTD-33772307-33773260
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258853
VEGA: 9
Homologene: 17415
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: EG637898, Casr-rs3, Gprc2a-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
Tchh
Name: trichohyalin
Synonyms: Thh, AHF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99681
Homologene: 136273
Ccn5
Name: cellular communication network factor 5
Synonyms: Wisp2, CCN5, Crgr4, rCop1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22403
Homologene: 2882
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, Flt-4, VEGFR-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Ccdc85a
Name: coiled-coil domain containing 85A
Synonyms: E030025D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216613
Homologene: 65605
Vmn2r109
Name: vomeronasal 2, receptor 109
Synonyms: EG627814
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 627814
Homologene: 129678
Atxn1l
Name: ataxin 1-like
Synonyms: C330011L24Rik, ENSMUSG00000069895, Boat, D8Ertd587e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52335
Homologene: 19471
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Mrps22
Name: mitochondrial ribosomal protein S22
Synonyms: 3100002P07Rik, Rpms22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 64655
Homologene: 57030
1700056E22Rik
Name: RIKEN cDNA 1700056E22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73363
Homologene: 137387
Crisp4
Name: cysteine-rich secretory protein 4
Synonyms: 9230112K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 78081
HGNC: HGNC:304
Homologene: 81683
Echdc3
Name: enoyl Coenzyme A hydratase domain containing 3
Synonyms: 2310005D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67856
Homologene: 11484
Olfr1002
Name: olfactory receptor 1002
Synonyms: GA_x6K02T2Q125-47127746-47126790, MOR175-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258566
Homologene: 104131
Nudt18
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 213484
VEGA: 14
Homologene: 32604
9030619P08Rik
Name: RIKEN cDNA 9030619P08 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105892
Znhit2
Name: zinc finger, HIT domain containing 2
Synonyms: ORF6, Znhit2-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 29805
HGNC: HGNC:1177
Homologene: 8477
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 18,122,794 bp
  • C to T, chromosome 1 at 184,033,505 bp
  • T to C, chromosome 2 at 6,212,800 bp
  • T to C, chromosome 2 at 76,795,664 bp
  • T to A, chromosome 2 at 85,647,560 bp
  • T to C, chromosome 2 at 91,770,896 bp
  • C to T, chromosome 2 at 119,072,573 bp
  • A to C, chromosome 2 at 125,372,527 bp
  • T to A, chromosome 2 at 163,829,077 bp
  • T to C, chromosome 2 at 180,500,601 bp
  • A to G, chromosome 3 at 32,915,708 bp
  • T to A, chromosome 3 at 56,058,040 bp
  • A to T, chromosome 3 at 93,444,972 bp
  • T to C, chromosome 3 at 94,520,233 bp
  • T to C, chromosome 3 at 95,500,874 bp
  • A to T, chromosome 4 at 62,304,609 bp
  • A to G, chromosome 5 at 73,064,925 bp
  • T to C, chromosome 5 at 73,110,271 bp
  • T to A, chromosome 5 at 109,292,904 bp
  • T to A, chromosome 5 at 135,132,718 bp
  • T to C, chromosome 5 at 142,470,114 bp
  • T to A, chromosome 5 at 147,599,646 bp
  • A to T, chromosome 6 at 83,756,544 bp
  • A to G, chromosome 6 at 95,497,582 bp
  • A to T, chromosome 6 at 104,832,509 bp
  • A to G, chromosome 6 at 149,068,490 bp
  • T to A, chromosome 7 at 5,328,431 bp
  • T to G, chromosome 7 at 19,259,033 bp
  • A to G, chromosome 7 at 30,574,940 bp
  • T to A, chromosome 7 at 42,137,052 bp
  • T to C, chromosome 7 at 105,758,178 bp
  • A to T, chromosome 8 at 3,849,124 bp
  • G to A, chromosome 8 at 84,726,526 bp
  • T to A, chromosome 8 at 109,732,980 bp
  • T to A, chromosome 9 at 14,799,639 bp
  • C to A, chromosome 9 at 40,074,896 bp
  • T to C, chromosome 9 at 45,945,704 bp
  • T to C, chromosome 9 at 70,034,333 bp
  • G to A, chromosome 9 at 95,950,636 bp
  • A to G, chromosome 9 at 98,594,695 bp
  • A to G, chromosome 9 at 107,995,296 bp
  • T to C, chromosome 10 at 83,496,025 bp
  • C to T, chromosome 10 at 127,719,279 bp
  • A to G, chromosome 11 at 28,396,150 bp
  • C to T, chromosome 11 at 49,636,339 bp
  • A to G, chromosome 11 at 60,499,430 bp
  • T to A, chromosome 11 at 84,164,628 bp
  • T to C, chromosome 12 at 44,590,164 bp
  • G to A, chromosome 12 at 54,181,693 bp
  • A to G, chromosome 12 at 100,403,439 bp
  • G to A, chromosome 13 at 44,884,892 bp
  • T to C, chromosome 14 at 7,896,503 bp
  • C to A, chromosome 14 at 63,139,104 bp
  • A to G, chromosome 14 at 70,579,427 bp
  • A to C, chromosome 15 at 75,429,997 bp
  • T to C, chromosome 15 at 82,177,519 bp
  • A to T, chromosome 17 at 20,555,241 bp
  • A to T, chromosome 18 at 6,214,044 bp
  • C to A, chromosome 19 at 6,062,258 bp
  • A to G, chromosome 19 at 56,861,760 bp
  • AGAGGAGGAGGAGGAGGA to AGAGGAGGAGGAGGA, chromosome X at 151,907,048 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1241 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039308-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.