Strain Name:
C57BL/6J-MtgxR1251Btlr/Mmmh
Stock Number:
039318-MU
Citation ID:
RRID:MMRRC_039318-MU
Other Names:
R1251 (G1), C57BL/6J-MtgxR1251Btlr
Major Collection:

Gene Information

Fgg
Name: fibrinogen gamma chain
Synonyms: gamma-fibrinogen, 3010002H13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99571
HGNC: HGNC:3694
Homologene: 429
Npc2
Name: NPC intracellular cholesterol transporter 2
Synonyms: HE1, 2700012J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 67963
VEGA: 12
Homologene: 4697
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Adcy9
Name: adenylate cyclase 9
Synonyms: D16Wsu65e, ACtp10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Ilrun
Name: inflammation and lipid regulator with UBA-like and NBR1-like domains
Synonyms: D17Wsu92e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224647
Homologene: 32575
Phf21a
Name: PHD finger protein 21A
Synonyms: 80kDa, Braf35/HDAC complex (Bhc), PFTF1, Bhc80, D030065N23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192285
Homologene: 9597
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15184
Homologene: 3995
Acap2
Name: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Synonyms: 9530039J15Rik, Centb2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 78618
VEGA: 16
Homologene: 8182
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, P1, Mcmd
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Nil2, [delta]EF1, MEB1, Tcf8, Zfx1a, Tcf18, AREB6, ZEB, Zfhep, 3110032K11Rik, Zfhx1a, Tw
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 21417
Homologene: 31779
Exoc2
Name: exocyst complex component 2
Synonyms: Sec5, 2410030I24Rik, Sec5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66482
Homologene: 10122
Rabgap1
Name: RAB GTPase activating protein 1
Synonyms: Gapcena
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227800
Homologene: 49301
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 24088
Homologene: 20695
Pold1
Name: polymerase (DNA directed), delta 1, catalytic subunit
Synonyms: 125kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18971
HGNC: HGNC:9175
Homologene: 2014
Sgo2a
Name: shugoshin 2A
Synonyms: 5730576N04Rik, Tripin, 1110007N04Rik, D1Ertd8e, Sgol2, Sgol2a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68549
Homologene: 51867
Nectin3
Name: nectin cell adhesion molecule 3
Synonyms: nectin-3, 4921513D19Rik, 2610301B19Rik, 3000002N23Rik, Pvrl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 58998
Homologene: 9162
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 170935
Homologene: 15781
Setd1a
Name: SET domain containing 1A
Synonyms: KMT2F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233904
Homologene: 52251
Clec18a
Name: C-type lectin domain family 18, member A
Synonyms: Mrcl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 353287
Homologene: 18755
Atp5j
Name: ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11957
HGNC: HGNC:847
Homologene: 1272
Copg1
Name: coatomer protein complex, subunit gamma 1
Synonyms: D6Ertd71e, D6Wsu16e, Copg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 54161
HGNC: HGNC:2236
Homologene: 56745
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 104401
Homologene: 17000
Tube1
Name: tubulin, epsilon 1
Synonyms: 2310061K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 71924
VEGA: 10
Homologene: 17762
Bcat2
Name: branched chain aminotransferase 2, mitochondrial
Synonyms: Eca40, Bcat-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 12036
HGNC: HGNC:977
Homologene: 81684
Calcrl
Name: calcitonin receptor-like
Synonyms: CRLR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 54598
Homologene: 21179
1700010I14Rik
Name: RIKEN cDNA 1700010I14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66931
Homologene: 49841
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22307
Homologene: 129606
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: 4921507O14Rik, D3Ertd789e, b2b1735Clo, b2b1304Clo, b2b2025.1Clo, prh
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 51938
Homologene: 12149
Eya2
Name: EYA transcriptional coactivator and phosphatase 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14049
HGNC: HGNC:3520
Homologene: 40711
Ccdc146
Name: coiled-coil domain containing 146
Synonyms: 4930528G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 75172
Homologene: 67159
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 75146
Homologene: 12592
Inpp4b
Name: inositol polyphosphate-4-phosphatase, type II
Synonyms: E130107I17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234515
HGNC: HGNC:6075
Homologene: 20832
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: STIP-1, NECAB1, 1700003H21Rik, Efcbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69352
Homologene: 11172
Coil
Name: coilin
Synonyms: p80-coilin, Cln80
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12812
HGNC: HGNC:2184
Homologene: 3413
Foxn1
Name: forkhead box N1
Synonyms: whn, Hfh11, D11Bhm185e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15218
Homologene: 2664
Olfr513
Name: olfactory receptor 513
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258718
Homologene: 64908
Cyp2j12
Name: cytochrome P450, family 2, subfamily j, polypeptide 12
Synonyms: OTTMUSG00000007939, Cyp2j12-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242546
Homologene: 133195
Olfr1036
Name: olfactory receptor 1036
Synonyms: GA_x6K02T2Q125-47549689-47550621, MOR245-25, MOR262-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258245
Irx6
Name: Iroquois homeobox 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 64379
Homologene: 41481
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Prss8
Name: protease, serine 8 (prostasin)
Synonyms: mCAP1, CAP1, 2410039E18Rik, fr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76560
HGNC: HGNC:9491
Homologene: 20613
Mfhas1
Name: malignant fibrous histiocytoma amplified sequence 1
Synonyms: 2310066G09Rik, D8Ertd91e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 52065
Homologene: 3114
Faim
Name: Fas apoptotic inhibitory molecule
Synonyms: Faim-L, Faim-S
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23873
Homologene: 8018
E030019B06Rik
Name: RIKEN cDNA E030019B06 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Eif3i
Name: eukaryotic translation initiation factor 3, subunit I
Synonyms: D4Ertd632e, 36kDa, Eif3s2, TRIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 54709
HGNC: HGNC:3272
Homologene: 2786
Sult2a8
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
Synonyms: 2810007J24Rik, mL-STL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76971
Il1rn
Name: interleukin 1 receptor antagonist
Synonyms: IL-1ra, F630041P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16181
HGNC: HGNC:6000
Homologene: 11163
Zc3h8
Name: zinc finger CCCH type containing 8
Synonyms: E130108N08Rik, Fliz1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 57432
Homologene: 10759
Tmem95
Name: transmembrane protein 95
Synonyms: 432576
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 100503361
VEGA: 11
Homologene: 77849
Gm15911
Name: predicted gene 15911
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 20,812,672 bp
  • A to T, chromosome 1 at 57,999,962 bp
  • A to G, chromosome 2 at 24,345,570 bp
  • A to G, chromosome 2 at 37,543,234 bp
  • G to T, chromosome 2 at 84,339,204 bp
  • G to A, chromosome 2 at 86,074,820 bp
  • G to A, chromosome 2 at 92,359,199 bp
  • G to A, chromosome 2 at 128,935,369 bp
  • T to A, chromosome 2 at 165,754,484 bp
  • T to C, chromosome 3 at 33,826,480 bp
  • T to A, chromosome 3 at 83,012,980 bp
  • T to C, chromosome 3 at 83,838,269 bp
  • A to G, chromosome 4 at 15,111,192 bp
  • G to A, chromosome 4 at 96,115,666 bp
  • T to C, chromosome 4 at 129,593,385 bp
  • T to C, chromosome 5 at 21,293,372 bp
  • T to C, chromosome 5 at 108,996,024 bp
  • A to T, chromosome 5 at 143,386,015 bp
  • A to T, chromosome 6 at 87,890,007 bp
  • T to A, chromosome 7 at 14,425,425 bp
  • C to T, chromosome 7 at 44,535,051 bp
  • T to G, chromosome 7 at 45,575,986 bp
  • T to G, chromosome 7 at 108,754,907 bp
  • T to A, chromosome 7 at 127,797,424 bp
  • T to C, chromosome 7 at 127,929,787 bp
  • C to T, chromosome 7 at 139,601,265 bp
  • A to G, chromosome 8 at 35,591,053 bp
  • G to A, chromosome 8 at 81,890,753 bp
  • A to G, chromosome 8 at 92,678,253 bp
  • T to C, chromosome 8 at 111,081,638 bp
  • C to T, chromosome 8 at 123,962,052 bp
  • C to T, chromosome 9 at 98,992,634 bp
  • G to T, chromosome 10 at 39,134,208 bp
  • A to G, chromosome 11 at 69,876,829 bp
  • A to G, chromosome 11 at 78,358,785 bp
  • A to G, chromosome 11 at 88,982,299 bp
  • G to A, chromosome 11 at 102,204,819 bp
  • A to G, chromosome 12 at 84,760,884 bp
  • T to C, chromosome 13 at 13,634,483 bp
  • T to A, chromosome 13 at 30,886,276 bp
  • T to A, chromosome 13 at 55,604,131 bp
  • T to A, chromosome 16 at 4,311,531 bp
  • A to T, chromosome 16 at 31,108,171 bp
  • A to T, chromosome 16 at 46,463,842 bp
  • A to T, chromosome 16 at 84,828,564 bp
  • T to C, chromosome 17 at 9,007,994 bp
  • C to T, chromosome 17 at 27,786,070 bp
  • T to A, chromosome 18 at 5,705,089 bp
  • A to G, chromosome 19 at 5,677,182 bp
  • T to C, chromosome 19 at 46,372,053 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1251 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039318-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.