Strain Name:
C57BL/6J-MtgxR1253Btlr/Mmmh
Stock Number:
039320-MU
Citation ID:
RRID:MMRRC_039320-MU
Other Names:
R1253 (G1), C57BL/6J-MtgxR1253Btlr
Major Collection:

Gene Information

Thbs4
Name: thrombospondin 4
Synonyms: TSP4, TSP-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 21828
Homologene: 20691
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 11426
Homologene: 136191
Dnm1l
Name: dynamin 1-like
Synonyms: Dnmlp1, 6330417M19Rik, Drp1, python
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 74006
VEGA: 16
HGNC: HGNC:2973
Homologene: 6384
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 208628
Homologene: 32227
Rbm27
Name: RNA binding motif protein 27
Synonyms: Psc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 225432
VEGA: 18
Homologene: 35410
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Ars2, 2810019G02Rik, Asr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 83701
Homologene: 9298
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 83946
Homologene: 41209
Cdhr1
Name: cadherin-related family member 1
Synonyms: Pcdh21, Prcad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 170677
VEGA: 14
Homologene: 13215
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71722
Homologene: 87637
Spg11
Name: SPG11, spatacsin vesicle trafficking associated
Synonyms: spastic paraplegia 11, 6030465E24Rik, C530005A01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 214585
Homologene: 41614
Tmtc3
Name: transmembrane and tetratricopeptide repeat containing 3
Synonyms: B130008E12Rik, mSmile, 9130014E20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 237500
Homologene: 27616
Olfm3
Name: olfactomedin 3
Synonyms: B230206G02Rik, optimedin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 229759
Homologene: 17103
Rexo2
Name: RNA exonuclease 2
Synonyms: Sfn, Smfn, 1810038D15Rik, Rex2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 104444
VEGA: 9
Homologene: 6447
Rtn4ip1
Name: reticulon 4 interacting protein 1
Synonyms: NIMP, D10Ertd690e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 170728
Homologene: 13105
Ugcg
Name: UDP-glucose ceramide glucosyltransferase
Synonyms: Ugcgl, Epcs21, GlcT-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 22234
Homologene: 37763
Ormdl1
Name: ORM1-like 1 (S. cerevisiae)
Synonyms: C730042F17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 227102
Homologene: 41135
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 245026
Homologene: 18260
4930458L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
Arvcf
Name: armadillo repeat gene deleted in velocardiofacial syndrome
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 11877
HGNC: HGNC:728
Homologene: 31046
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268932
VEGA: 17
Homologene: 25873
Ptprt
Name: protein tyrosine phosphatase, receptor type, T
Synonyms: RPTPrho
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 19281
HGNC: HGNC:9682
Homologene: 56924
Glmn
Name: glomulin, FKBP associated protein
Synonyms: Fap68, 9330160J16Rik, Fap48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 170823
Homologene: 14239
Cyp2c54
Name: cytochrome P450, family 2, subfamily c, polypeptide 54
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 404195
VEGA: 19
Homologene: 137231
Mtus2
Name: microtubule associated tumor suppressor candidate 2
Synonyms: A730013O20Rik, 5730592G18Rik, C130038G02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 77521
Homologene: 78141
Vmn2r92
Name: vomeronasal 2, receptor 92
Synonyms: EG627111
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 627111
Homologene: 115024
Dpy19l3
Name: dpy-19-like 3 (C. elegans)
Synonyms: 9330164H19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233115
Homologene: 18692
Large1
Name: LARGE xylosyl- and glucuronyltransferase 1
Synonyms: froggy, enr, fg, BPFD#36
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 16795
HGNC: HGNC:6511
Homologene: 7810
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, Pcdh3, PcdhbL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93883
Homologene: 87126
Serpinb9e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9e
Synonyms: NK26, Spi14, ovalbumin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20710
HGNC: HGNC:8955
Homologene: 69093
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, SKIP, 4930544G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 77629
Homologene: 18172
Actg2
Name: actin, gamma 2, smooth muscle, enteric
Synonyms: Act4, SMGA, Acta3, Act-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 11468
HGNC: HGNC:145
Homologene: 123845
Olfr290
Name: olfactory receptor 290
Synonyms: MOR254-1, GA_x6K02T2NHDJ-11170115-11169168
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258411
Homologene: 83130
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 66673
VEGA: 19
Homologene: 8986
Tas2r129
Name: taste receptor, type 2, member 129
Synonyms: mGR29, mt2r60, T2R29, Tas2r29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 387354
Homologene: 130074
Lrp8
Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Synonyms: apoER2, 4932703M08Rik, Lr8b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16975
HGNC: HGNC:6700
Homologene: 31250
Aph1b
Name: aph1 homolog B, gamma secretase subunit
Synonyms: 2310057K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 208117
Homologene: 12844
Olfr364-ps1
Name: olfactory receptor 364, pseudogene 1
Synonyms: GA_x6K02T2NLDC-33831282-33832243, MOR138-4P, MOR138-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227794
HGNC: HGNC:8216
Olfr731
Name: olfactory receptor 731
Synonyms: MOR246-5, GA_x6K02T2PMLR-5936117-5935137
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 258360
Homologene: 84579
Ccdc137
Name: coiled-coil domain containing 137
Synonyms: 3110023B02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67291
Homologene: 34992
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 53,305,522 bp
  • G to A, chromosome 1 at 83,278,898 bp
  • T to A, chromosome 2 at 37,146,872 bp
  • T to C, chromosome 2 at 122,073,012 bp
  • A to G, chromosome 2 at 162,278,226 bp
  • A to T, chromosome 3 at 115,122,769 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • C to A, chromosome 4 at 107,869,161 bp
  • A to T, chromosome 4 at 123,457,967 bp
  • T to C, chromosome 5 at 107,557,349 bp
  • AGTGT to AGT, chromosome 5 at 123,810,862 bp
  • T to C, chromosome 5 at 137,300,336 bp
  • C to T, chromosome 5 at 148,303,570 bp
  • G to A, chromosome 6 at 83,522,887 bp
  • T to C, chromosome 6 at 132,952,036 bp
  • T to A, chromosome 7 at 25,290,948 bp
  • G to T, chromosome 7 at 35,729,678 bp
  • T to A, chromosome 7 at 84,916,709 bp
  • T to C, chromosome 8 at 73,048,422 bp
  • A to T, chromosome 9 at 48,468,932 bp
  • T to A, chromosome 9 at 66,790,649 bp
  • A to T, chromosome 9 at 82,894,226 bp
  • T to A, chromosome 9 at 105,774,303 bp
  • A to T, chromosome 10 at 43,910,871 bp
  • T to C, chromosome 10 at 100,451,390 bp
  • C to A, chromosome 11 at 120,458,179 bp
  • T to C, chromosome 13 at 33,255,119 bp
  • A to G, chromosome 13 at 64,922,024 bp
  • G to T, chromosome 13 at 92,776,905 bp
  • A to G, chromosome 14 at 37,079,625 bp
  • A to G, chromosome 14 at 50,238,124 bp
  • G to A, chromosome 16 at 16,316,452 bp
  • A to G, chromosome 16 at 18,405,095 bp
  • T to A, chromosome 17 at 18,166,766 bp
  • A to G, chromosome 17 at 24,505,073 bp
  • G to A, chromosome 18 at 37,435,821 bp
  • A to C, chromosome 18 at 42,301,774 bp
  • T to A, chromosome 19 at 40,046,185 bp
  • C to A, chromosome 19 at 48,206,736 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1253 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039320-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.