Strain Name:
C57BL/6J-MtgxR1256Btlr/Mmmh
Stock Number:
039323-MU
Citation ID:
RRID:MMRRC_039323-MU
Other Names:
R1256 (G1), C57BL/6J-MtgxR1256Btlr
Major Collection:

Gene Information

Nes
Name: nestin
Synonyms: RC2, Ifaprc2, ESTM46, Marc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 18008
HGNC: HGNC:7756
Homologene: 136487
Vsx2
Name: visual system homeobox 2
Synonyms: Hox-10, Hox10, Chx10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 12677
HGNC: HGNC:1975
Homologene: 7266
Strn
Name: striatin, calmodulin binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268980
Homologene: 2380
Cd2ap
Name: CD2-associated protein
Synonyms: METS-1, Mets1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 12488
VEGA: 17
Homologene: 7663
Pepd
Name: peptidase D
Synonyms: peptidase D, Pep4, Pep-4, dal
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18624
HGNC: HGNC:8840
Homologene: 239
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: KMT6, Enx1h, Enx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Schip1
Name: schwannomin interacting protein 1
Synonyms: SCHIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 30953
Homologene: 130673
Smg1
Name: SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Synonyms: 5430435M13Rik, C130002K18Rik, 2610207I05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233789
Homologene: 56697
Rnf20
Name: ring finger protein 20
Synonyms: 4833430L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 109331
Homologene: 5571
Apaf1
Name: apoptotic peptidase activating factor 1
Synonyms: Apaf1l, 6230400I06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 11783
HGNC: HGNC:576
Homologene: 7626
Cnot10
Name: CCR4-NOT transcription complex, subunit 10
Synonyms: 2600001P13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 78893
VEGA: 9
Homologene: 41040
Vps26c
Name: VPS26 endosomal protein sorting factor C
Synonyms: Down syndrome critical region gene 3, Dcra, Dscr3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 13185
HGNC: HGNC:3044
Homologene: 4415
Cln3
Name: ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)
Synonyms: battenin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 12752
HGNC: HGNC:2074
Homologene: 37259
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: 4930400K19Rik, 2310003F20Rik, Garnl1, Tulip1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56784
VEGA: 12
Homologene: 84805
Psip1
Name: PC4 and SFRS1 interacting protein 1
Synonyms: Psip2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 101739
HGNC: HGNC:9527
Homologene: 13242
Nif3l1
Name: Ngg1 interacting factor 3-like 1 (S. pombe)
Synonyms: 1110030G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 65102
Homologene: 5881
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231841
Homologene: 16776
Pcbp2
Name: poly(rC) binding protein 2
Synonyms: Hnrpx, alphaCP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 18521
VEGA: 15
HGNC: HGNC:8648
Homologene: 74536
Uty
Name: ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
Synonyms: Hydb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: Y
Alteration at locus: Chemically Induced
NCBI: 22290
Txnl4a
Name: thioredoxin-like 4A
Synonyms: Txnl4, D18Wsu98e, ENSMUSG00000057130, U5-15kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 27366
Homologene: 7150
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 99470
Homologene: 26431
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 94109
Homologene: 69536
Mcu
Name: mitochondrial calcium uniporter
Synonyms: 2010012O16Rik, Ccdc109a, D130073L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 215999
Homologene: 9916
Pik3r6
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p84 Pikap, p87PIKAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104709
Homologene: 46215
Arhgef11
Name: Rho guanine nucleotide exchange factor (GEF) 11
Synonyms: PDZ-RhoGEF, Prg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 213498
Homologene: 11409
Kcnj16
Name: potassium inwardly-rectifying channel, subfamily J, member 16
Synonyms: Kir5.1, 6430410F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16517
HGNC: HGNC:6262
Homologene: 23112
Spn
Name: sialophorin
Synonyms: leukosialin, Cd43, Ly48, Galgp, 3E8 antigen, Ly-48, A630014B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 20737
Homologene: 36108
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: Cryabp1, alphaA-CRYBP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Sspo
Name: SCO-spondin
Synonyms: C79529, Scospondin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 243369
Homologene: 45453
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 76645
Homologene: 124481
Olfr177
Name: olfactory receptor 177
Synonyms: GA_x54KRFPKG5P-55091371-55090442, MOR184-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258998
Homologene: 121500
Olfr144
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
Pcdhb9
Name: protocadherin beta 9
Synonyms: Pcdhb4C, PcdhbI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 93880
Homologene: 87124
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 67155
Homologene: 2308
Abcb10
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Synonyms: ABC-me
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 56199
HGNC: HGNC:41
Homologene: 6474
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: A630007B06Rik, 1810028B20Rik, Otg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 213993
Homologene: 9963
Msln
Name: mesothelin
Synonyms: MPF, megakaryocyte potentiating factor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 56047
VEGA: 17
HGNC: HGNC:7371
Homologene: 4249
Capn10
Name: calpain 10
Synonyms: Capn8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 23830
HGNC: HGNC:1477
Homologene: 36323
Olfr1262
Name: olfactory receptor 1262
Synonyms: MOR234-1, GA_x6K02T2Q125-51434523-51435437
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258976
Homologene: 74064
Tstd3
Name: thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
Synonyms: 2610029I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 77032
Homologene: 123813
Poglut3
Name: protein O-glucosyltransferase 3
Synonyms: Kdelc2, 2010004J24Rik, 4833410J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 68304
VEGA: 9
Homologene: 17805
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,455,649 bp
  • C to T, chromosome 1 at 92,946,946 bp
  • A to T, chromosome 2 at 90,002,567 bp
  • A to T, chromosome 3 at 68,495,042 bp
  • A to G, chromosome 3 at 87,727,135 bp
  • A to G, chromosome 3 at 87,976,576 bp
  • C to T, chromosome 3 at 104,027,810 bp
  • T to C, chromosome 4 at 21,759,627 bp
  • A to G, chromosome 4 at 49,638,230 bp
  • A to G, chromosome 4 at 83,474,367 bp
  • A to G, chromosome 5 at 140,710,207 bp
  • A to T, chromosome 6 at 47,541,855 bp
  • G to A, chromosome 6 at 48,457,639 bp
  • A to C, chromosome 7 at 34,921,492 bp
  • A to G, chromosome 7 at 44,522,417 bp
  • T to C, chromosome 7 at 118,203,087 bp
  • A to G, chromosome 7 at 126,583,036 bp
  • T to C, chromosome 7 at 127,136,273 bp
  • A to T, chromosome 8 at 16,079,964 bp
  • C to T, chromosome 8 at 117,019,543 bp
  • C to T, chromosome 8 at 123,962,052 bp
  • G to C, chromosome 9 at 39,238,251 bp
  • A to C, chromosome 9 at 53,388,462 bp
  • G to T, chromosome 9 at 114,610,681 bp
  • G to T, chromosome 10 at 59,454,968 bp
  • A to G, chromosome 10 at 91,058,406 bp
  • T to C, chromosome 11 at 68,527,072 bp
  • A to G, chromosome 11 at 111,025,436 bp
  • T to C, chromosome 12 at 55,762,661 bp
  • T to A, chromosome 12 at 84,576,311 bp
  • T to C, chromosome 12 at 112,914,419 bp
  • C to T, chromosome 13 at 42,181,831 bp
  • A to G, chromosome 15 at 102,485,944 bp
  • A to C, chromosome 16 at 58,872,843 bp
  • A to G, chromosome 16 at 94,512,366 bp
  • A to G, chromosome 17 at 25,754,183 bp
  • A to T, chromosome 17 at 42,816,101 bp
  • A to C, chromosome 17 at 78,664,617 bp
  • A to G, chromosome 18 at 37,403,116 bp
  • A to G, chromosome 18 at 80,207,272 bp
  • A to G, chromosome 19 at 26,681,973 bp
  • G to T, chromosome 19 at 56,797,621 bp
  • T to C, chromosome Y at 1,134,884 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1256 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039323-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.