Strain Name:
C57BL/6J-MtgxR1264Btlr/Mmmh
Stock Number:
039331-MU
Citation ID:
RRID:MMRRC_039331-MU
Other Names:
R1264 (G1), C57BL/6J-MtgxR1264Btlr
Major Collection:

Gene Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: urehr3, D630042G03Rik, Nkcc2, mBSC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 20495
Homologene: 286
Acadl
Name: acyl-Coenzyme A dehydrogenase, long-chain
Synonyms: LCAD, C79855
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11363
HGNC: HGNC:88
Homologene: 37498
Angpt2
Name: angiopoietin 2
Synonyms: Ang-2, Ang2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 11601
HGNC: HGNC:485
Homologene: 22401
Poli
Name: polymerase (DNA directed), iota
Synonyms: Rad30b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 26447
HGNC: HGNC:9182
Homologene: 5209
Ano6
Name: anoctamin 6
Synonyms: F730003B03Rik, 2900059G15Rik, Tmem16f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 105722
VEGA: 15
Homologene: 27888
Kif13b
Name: kinesin family member 13B
Synonyms: 5330429L19Rik, N-3 kinesin, GAKIN, C130021D12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 16554
VEGA: 14
Homologene: 9073
Tfdp1
Name: transcription factor Dp 1
Synonyms: Dp1, Drtf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 21781
Homologene: 38276
Ascc3
Name: activating signal cointegrator 1 complex subunit 3
Synonyms: ASC1p200, B630009I04Rik, Helic1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 77987
VEGA: 10
Homologene: 4973
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 208846
VEGA: 12
Homologene: 36635
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Trrap
Name: transformation/transcription domain-associated protein
Synonyms: transactivation/transformation-domain associated protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 100683
Homologene: 39246
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 217995
VEGA: 13
Homologene: 34562
Wbp11
Name: WW domain binding protein 11
Synonyms: Npwbp, 2510026P17Rik, SIPP1, D6Wsu113e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 60321
Homologene: 134037
Sptb
Name: spectrin beta, erythrocytic
Synonyms: spectrin R, brain erythroid spectrin (235E), LOC383567, Spnb-1, Spnb1, D330027P03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 20741
Homologene: 295
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Nob1
Name: NIN1/RPN12 binding protein 1 homolog
Synonyms: ART-4, 1700021I09Rik, Nob1p, Psmd8bp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 67619
Homologene: 31924
Clec10a
Name: C-type lectin domain family 10, member A
Synonyms: CD301a, Mgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17312
Homologene: 7836
Six3
Name: sine oculis-related homeobox 3
Synonyms: E130112M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 20473
Homologene: 3947
Col4a3
Name: collagen, type IV, alpha 3
Synonyms: alpha3(IV), tumstatin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 12828
HGNC: HGNC:2204
Homologene: 68033
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: cAMP-GEFII, 5730402K07Rik, 1300003D15Rik, 6330581N18Rik, Epac2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 56508
Homologene: 4451
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Adgrb3
Name: adhesion G protein-coupled receptor B3
Synonyms: Bai3, A830096D10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 210933
HGNC: HGNC:945
Homologene: 1289
Impg1
Name: interphotoreceptor matrix proteoglycan 1
Synonyms: A930015H12Rik, SPACR, IMP150
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 63859
HGNC: HGNC:6055
Homologene: 1201
Plekhs1
Name: pleckstrin homology domain containing, family S member 1
Synonyms: 9930023K05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226245
VEGA: 19
Homologene: 11770
H2-M9
Name: histocompatibility 2, M region locus 9
Synonyms: M9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14997
Homologene: 110792
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhsf1, Myhs-f1, MyHC-IIa, MHC2A, Myhs-f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Pard3b
Name: par-3 family cell polarity regulator beta
Synonyms: 1810008K04Rik, 2010002N16Rik, Als2cr19, 2810455B10Rik, PAR3beta, PAR3B, PAR3L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 72823
Homologene: 35389
Abcc9
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Synonyms: SUR2A, SUR2B, Sur2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 20928
HGNC: HGNC:60
Homologene: 56521
Myo18b
Name: myosin XVIIIb
Synonyms: 4933411E19Rik, 4932408L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74376
Homologene: 53435
Olfr1427
Name: olfactory receptor 1427
Synonyms: GA_x6K02T2RE5P-2458473-2457538, MOR239-4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258674
Homologene: 128080
Shisa6
Name: shisa family member 6
Synonyms: Gm879, CKAMP52, LOC380702
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 380702
Homologene: 66164
Clstn2
Name: calsyntenin 2
Synonyms: CS2, Cst-2, 2900042C18Rik, CSTN2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 64085
Homologene: 49698
Cndp2
Name: CNDP dipeptidase 2 (metallopeptidase M20 family)
Synonyms: 0610010E05Rik, Cn2, Dip-2, Pep1, Pep-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 66054
VEGA: 18
Homologene: 10085
Aknaos
Name: AT-hook transcription factor, opposite strand
Synonyms: 4933437N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 66783
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 25,559,850 bp
  • A to T, chromosome 1 at 62,164,157 bp
  • A to T, chromosome 1 at 66,857,553 bp
  • A to T, chromosome 1 at 82,643,301 bp
  • A to T, chromosome 2 at 72,031,105 bp
  • A to T, chromosome 2 at 125,218,238 bp
  • T to C, chromosome 4 at 63,381,725 bp
  • T to C, chromosome 5 at 112,830,319 bp
  • A to G, chromosome 5 at 144,789,599 bp
  • A to G, chromosome 6 at 136,814,515 bp
  • T to C, chromosome 6 at 142,646,377 bp
  • C to A, chromosome 8 at 13,373,837 bp
  • T to C, chromosome 8 at 18,741,217 bp
  • T to C, chromosome 8 at 107,421,504 bp
  • A to G, chromosome 9 at 79,620,089 bp
  • T to C, chromosome 9 at 80,314,393 bp
  • T to C, chromosome 9 at 97,457,609 bp
  • A to T, chromosome 10 at 50,642,519 bp
  • T to G, chromosome 10 at 77,993,416 bp
  • T to C, chromosome 11 at 66,375,149 bp
  • A to G, chromosome 11 at 67,180,778 bp
  • T to A, chromosome 11 at 70,169,741 bp
  • A to G, chromosome 12 at 71,975,311 bp
  • A to G, chromosome 12 at 76,612,607 bp
  • T to A, chromosome 13 at 12,424,610 bp
  • T to C, chromosome 14 at 64,776,232 bp
  • A to G, chromosome 15 at 95,949,566 bp
  • A to G, chromosome 17 at 36,642,592 bp
  • T to A, chromosome 17 at 85,621,857 bp
  • T to A, chromosome 17 at 87,707,179 bp
  • C to T, chromosome 18 at 70,517,503 bp
  • C to A, chromosome 18 at 84,678,791 bp
  • T to C, chromosome 19 at 9,884,015 bp
  • G to T, chromosome 19 at 12,098,834 bp
  • T to C, chromosome 19 at 56,485,763 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1264 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039331-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.