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Strain Name:
C57BL/6J-MtgxR1270Btlr/Mmmh
Stock Number:
039336-MU
Citation ID:
RRID:MMRRC_039336-MU
Other Names:
R1270 (G1), C57BL/6J-MtgxR1270Btlr
Major Collection:

Strain Information

Glrx3
Name: glutaredoxin 3
Synonyms: PKC interacting cousin of thioredoxin, PICOT, Txnl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30926
Homologene: 4769
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66875
Homologene: 32355
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: Tweek, FSA, 4932438A13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: Ten-m2, D3Bwg1534e, 9330187F13Rik, 2610040L17Rik, Odz2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23964
Homologene: 22672
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Trim2
Name: tripartite motif-containing 2
Synonyms: neural activity-related ring finger protein, narf
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80890
Homologene: 22882
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234699
Homologene: 40937
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 435684
Homologene: 44524
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Aldh1a7, Raldh2, retinaldehyde dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19378
Homologene: 68368
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Synonyms: Kiaa0319
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210108
Homologene: 8878
Taar1
Name: trace amine-associated receptor 1
Synonyms: Tar1, Trar1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: Bph, brachyphalangy
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Cdh2
Name: cadherin 2
Synonyms: N-cadherin, Ncad, N-CAD
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Cep250
Name: centrosomal protein 250
Synonyms: Inmp, B230210E21Rik, Cep2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Mrgpra9
Name: MAS-related GPR, member A9
Synonyms: MrgA9, EG668725
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668725
Homologene: 79615
Bhmt-ps1
Name: betaine-homocysteine methyltransferase, pseudogene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 57421
Ceacam1
Name: CEA cell adhesion molecule 1
Synonyms: CD66a, MHVR1, mmCGM1, mCEA1, mmCGM2, Hv-2, Bgp, Mhv-1, Cea-7, Cea-1, Cea1, Bgp1, C-CAM, Hv2, Cea7, Cc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26365
Homologene: 128630
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: Aatyk3, AATYK3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381983
Homologene: 79449
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19153
Homologene: 76542
Or8g17
Name: olfactory receptor family 8 subfamily G member 17
Synonyms: M15, MOR171-10, GA_x6K02T2PVTD-32715386-32714466, Olfr146
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258742
VEGA: 9
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, CD227, Muc-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104816
VEGA: 12
Homologene: 113390
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: D17Ertd562e, 2410004N11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66989
Homologene: 12063
Or4a47
Name: olfactory receptor family 4 subfamily A member 47
Synonyms: GA_x6K02T2Q125-51276848-51275928, MOR231-1, Olfr1256
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258985
Homologene: 128157
Alg9
Name: ALG9 alpha-1,2-mannosyltransferase
Synonyms: 8230402H15Rik, B430313H07Rik, Dibd1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102580
Homologene: 6756
Ube2q2l
Name: ubiquitin conjugating enzyme E2 Q2 like
Synonyms: E330021D16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100502936
Enkd1
Name: enkurin domain containing 1
Synonyms: E130303B06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102124
Homologene: 12957
Tff2
Name: trefoil factor 2 (spasmolytic protein 1)
Synonyms: mSP, SP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21785
Homologene: 3956
C4a
Name: complement C4A (Rodgers blood group)
Synonyms: Slp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 625018
Homologene: 36030
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 87,934,125 bp
  • A to T, chromosome 1 at 151,384,391 bp
  • C to T, chromosome 2 at 89,835,322 bp
  • G to A, chromosome 2 at 122,368,682 bp
  • G to A, chromosome 2 at 155,990,681 bp
  • T to A, chromosome 3 at 36,952,184 bp
  • G to A, chromosome 3 at 84,167,677 bp
  • T to A, chromosome 3 at 89,232,107 bp
  • T to C, chromosome 4 at 26,369,475 bp
  • A to T, chromosome 4 at 113,942,659 bp
  • A to T, chromosome 6 at 136,401,787 bp
  • T to C, chromosome 7 at 25,466,314 bp
  • T to A, chromosome 7 at 27,518,930 bp
  • A to G, chromosome 7 at 45,793,828 bp
  • A to T, chromosome 7 at 47,252,783 bp
  • A to G, chromosome 7 at 137,453,414 bp
  • A to G, chromosome 8 at 105,703,901 bp
  • A to G, chromosome 8 at 105,891,264 bp
  • A to T, chromosome 9 at 21,772,760 bp
  • A to C, chromosome 9 at 39,019,247 bp
  • A to G, chromosome 9 at 50,787,572 bp
  • T to G, chromosome 9 at 71,281,706 bp
  • T to C, chromosome 10 at 23,920,533 bp
  • T to C, chromosome 11 at 36,041,659 bp
  • C to T, chromosome 11 at 86,233,085 bp
  • C to T, chromosome 11 at 94,357,384 bp
  • C to T, chromosome 12 at 112,116,447 bp
  • C to T, chromosome 13 at 15,723,744 bp
  • T to C, chromosome 13 at 24,857,338 bp
  • T to A, chromosome 14 at 68,527,669 bp
  • A to G, chromosome 17 at 28,966,931 bp
  • C to T, chromosome 17 at 31,144,169 bp
  • A to G, chromosome 17 at 34,814,528 bp
  • T to G, chromosome 18 at 16,627,557 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1270 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039336-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.