Strain Name:
C57BL/6J-MtgxR1270Btlr/Mmmh
Stock Number:
039336-MU
Citation ID:
RRID:MMRRC_039336-MU
Other Names:
R1270 (G1), C57BL/6J-MtgxR1270Btlr
Major Collection:

Gene Information

Glrx3
Name: glutaredoxin 3
Synonyms: PICOT, PKC interacting cousin of thioredoxin, Txnl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 30926
Homologene: 4769
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66875
Homologene: 32355
4932438A13Rik
Name: RIKEN cDNA 4932438A13 gene
Synonyms: Tweek, FSA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229227
Homologene: 52105
Kank2
Name: KN motif and ankyrin repeat domains 2
Synonyms: Ankrd25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235041
VEGA: 9
Homologene: 9163
Tenm2
Name: teneurin transmembrane protein 2
Synonyms: 9330187F13Rik, D3Bwg1534e, Ten-m2, 2610040L17Rik, Odz2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 23964
Homologene: 22672
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: dgkd-2, DGKdelta
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Trim2
Name: tripartite motif-containing 2
Synonyms: narf, neural activity-related ring finger protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 80890
Homologene: 22882
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 70422
Homologene: 10801
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Shf
Name: Src homology 2 domain containing F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 435684
Homologene: 44524
Aldh1a2
Name: aldehyde dehydrogenase family 1, subfamily A2
Synonyms: Raldh2, retinaldehyde dehydrogenase, Aldh1a7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 19378
Homologene: 68368
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 210108
Homologene: 8878
Taar1
Name: trace amine-associated receptor 1
Synonyms: Tar1, Trar1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 111174
VEGA: 10
Homologene: 24938
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242627
Homologene: 135888
Gli3
Name: GLI-Kruppel family member GLI3
Synonyms: brachyphalangy, Bph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 14634
HGNC: HGNC:4319
Homologene: 139
Cdh2
Name: cadherin 2
Synonyms: N-CAD, N-cadherin, Ncad
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Adam7
Name: a disintegrin and metallopeptidase domain 7
Synonyms: EAP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11500
HGNC: HGNC:214
Homologene: 2830
Abcc3
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Cep250
Name: centrosomal protein 250
Synonyms: Cep2, Inmp, B230210E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16328
HGNC: HGNC:1859
Homologene: 38286
Mrgpra9
Name: MAS-related GPR, member A9
Synonyms: MrgA9, EG668725
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 668725
Homologene: 79615
Bhmt-ps1
Name: betaine-homocysteine methyltransferase, pseudogene 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 57421
Ceacam1
Name: carcinoembryonic antigen-related cell adhesion molecule 1
Synonyms: CD66a, Cea7, mmCGM2, mCEA1, mmCGM1, Cea-1, Cc1, Mhv-1, Bgp, Hv2, Hv-2, Cea-7, Cea1, MHVR1, Bgp1, C-CAM
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26365
HGNC: HGNC:1814
Homologene: 128630
Lmtk3
Name: lemur tyrosine kinase 3
Synonyms: AATYK3, Aatyk3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381983
Homologene: 79449
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 19153
Homologene: 76542
Olfr146
Name: olfactory receptor 146
Synonyms: MOR171-10, GA_x6K02T2PVTD-32715386-32714466, M15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258742
VEGA: 9
Muc1
Name: mucin 1, transmembrane
Synonyms: EMA, Muc-1, CD227
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104816
VEGA: 12
Homologene: 113390
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: D17Ertd562e, 2410004N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66989
Homologene: 12063
Olfr1256
Name: olfactory receptor 1256
Synonyms: GA_x6K02T2Q125-51276848-51275928, MOR231-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258985
Homologene: 128157
Alg9
Name: asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
Synonyms: B430313H07Rik, Dibd1, 8230402H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 102580
Homologene: 6756
E330021D16Rik
Name: RIKEN cDNA E330021D16 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 100502936
Enkd1
Name: enkurin domain containing 1
Synonyms: E130303B06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102124
Homologene: 12957
Tff2
Name: trefoil factor 2 (spasmolytic protein 1)
Synonyms: mSP, SP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 21785
Homologene: 3956
C4a
Name: complement component 4A (Rodgers blood group)
Synonyms: Slp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 625018
Homologene: 36030
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 87,934,125 bp
  • A to T, chromosome 1 at 151,384,391 bp
  • C to T, chromosome 2 at 89,835,322 bp
  • G to A, chromosome 2 at 122,368,682 bp
  • G to A, chromosome 2 at 155,990,681 bp
  • T to A, chromosome 3 at 36,952,184 bp
  • G to A, chromosome 3 at 84,167,677 bp
  • T to A, chromosome 3 at 89,232,107 bp
  • T to C, chromosome 4 at 26,369,475 bp
  • A to T, chromosome 4 at 113,942,659 bp
  • A to T, chromosome 6 at 136,401,787 bp
  • T to C, chromosome 7 at 25,466,314 bp
  • T to A, chromosome 7 at 27,518,930 bp
  • A to G, chromosome 7 at 45,793,828 bp
  • A to T, chromosome 7 at 47,252,783 bp
  • A to G, chromosome 7 at 137,453,414 bp
  • A to G, chromosome 8 at 105,703,901 bp
  • A to G, chromosome 8 at 105,891,264 bp
  • A to T, chromosome 9 at 21,772,760 bp
  • A to C, chromosome 9 at 39,019,247 bp
  • A to G, chromosome 9 at 50,787,572 bp
  • T to G, chromosome 9 at 71,281,706 bp
  • T to C, chromosome 10 at 23,920,533 bp
  • T to C, chromosome 11 at 36,041,659 bp
  • C to T, chromosome 11 at 86,233,085 bp
  • C to T, chromosome 11 at 94,357,384 bp
  • C to T, chromosome 12 at 112,116,447 bp
  • C to T, chromosome 13 at 15,723,744 bp
  • T to C, chromosome 13 at 24,857,338 bp
  • T to A, chromosome 14 at 68,527,669 bp
  • A to G, chromosome 17 at 28,966,931 bp
  • C to T, chromosome 17 at 31,144,169 bp
  • A to G, chromosome 17 at 34,814,528 bp
  • T to G, chromosome 18 at 16,627,557 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1270 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039336-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.