Strain Name:
C57BL/6J-MtgxR1279Btlr/Mmmh
Stock Number:
039345-MU
Citation ID:
RRID:MMRRC_039345-MU
Other Names:
R1279 (G1), C57BL/6J-MtgxR1279Btlr
Major Collection:

Strain Information

Nrcam
Name: neuronal cell adhesion molecule
Synonyms: C030017F07Rik, Bravo, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: 1110020K19Rik, Uhrf1bp1, F830021D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: Ddxbp1, GBP, 2900068C24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Akap8l
Name: A kinase anchor protein 8-like
Synonyms: Nakap95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54194
VEGA: 17
Homologene: 8658
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Ppp4r2
Name: protein phosphatase 4, regulatory subunit 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232314
Homologene: 17953
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Oat
Name: ornithine aminotransferase
Synonyms: rhg
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18242
HGNC: HGNC:8091
Homologene: 231
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Or5h17
Name: olfactory receptor family 5 subfamily H member 17
Synonyms: MOR183-2, Olfr183, GA_x54KRFPKG5P-55229158-55230087
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258478
Homologene: 27178
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Slc2a2
Name: solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms: Glut2, Glut-2, liver-type glucose transporter
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20526
Homologene: 68047
Or10h5
Name: olfactory receptor family 10 subfamily H member 5
Synonyms: Olfr1564, Gm4461
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100043474
Homologene: 133726
Atp6v0d2
Name: ATPase, H+ transporting, lysosomal V0 subunit D2
Synonyms: 1620401A02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242341
Homologene: 72090
Mfap5
Name: microfibrillar associated protein 5
Synonyms: MAGP-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50530
Homologene: 2599
Gjb3
Name: gap junction protein, beta 3
Synonyms: Cx31, connexin 31, Cnx31, Gjb-3, D4Wsu144e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14620
HGNC: HGNC:4285
Homologene: 7338
Sypl2
Name: synaptophysin like 2
Synonyms: Mg29
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17306
Homologene: 7421
Or2n1c
Name: olfactory receptor family 2 subfamily N member 1C
Synonyms: Olfr135, MOR256-48, GA_x6K02T2PSCP-2656648-2657586
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258329
Homologene: 110603
Gm2042
Name: predicted gene 2042
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039087
Homologene: 103830
Myb
Name: myeloblastosis oncogene
Synonyms: c-myb
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17863
HGNC: HGNC:7545
Homologene: 31311
Padi3
Name: peptidyl arginine deiminase, type III
Synonyms: Pad3, PAD type III, Pdi3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18601
Homologene: 7882
Zp1
Name: zona pellucida glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22786
Homologene: 33483
Vmn1r7
Name: vomeronasal 1 receptor 7
Synonyms: V1rc31, Gm5568
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 434016
Homologene: 83427
Oas1a
Name: 2'-5' oligoadenylate synthetase 1A
Synonyms: L3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246730
HGNC: HGNC:8086
Homologene: 1903
Tacr1
Name: tachykinin receptor 1
Synonyms: NK1-R, substance p receptor, SPr, Tac1r, NK1 receptor, NK-1R, neurokinin receptor 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21336
Homologene: 20288
Gm17305
Name: predicted gene, 17305
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 3 at 28,717,543 bp
  • A to G, chromosome 3 at 108,217,674 bp
  • A to T, chromosome 4 at 19,878,298 bp
  • G to A, chromosome 4 at 127,326,431 bp
  • T to C, chromosome 4 at 140,803,577 bp
  • A to G, chromosome 5 at 120,897,178 bp
  • T to C, chromosome 6 at 57,024,949 bp
  • G to T, chromosome 6 at 82,557,183 bp
  • A to T, chromosome 6 at 100,865,918 bp
  • A to G, chromosome 6 at 122,526,763 bp
  • A to T, chromosome 7 at 132,567,080 bp
  • A to G, chromosome 9 at 62,892,145 bp
  • T to C, chromosome 9 at 105,777,540 bp
  • T to C, chromosome 10 at 21,148,326 bp
  • C to A, chromosome 10 at 52,142,166 bp
  • TCTCCTCCTCCTCCTCCTCCTC to TCTCCTCCTCCTCCTCCTC, chromosome 11 at 69,369,349 bp
  • A to T, chromosome 11 at 106,335,682 bp
  • T to C, chromosome 12 at 44,544,877 bp
  • C to T, chromosome 12 at 88,175,880 bp
  • G to A, chromosome 15 at 89,162,321 bp
  • A to T, chromosome 16 at 15,690,282 bp
  • G to A, chromosome 16 at 59,000,138 bp
  • T to C, chromosome 17 at 27,890,071 bp
  • C to T, chromosome 17 at 32,332,483 bp
  • T to C, chromosome 17 at 33,216,326 bp
  • A to G, chromosome 17 at 38,208,787 bp
  • A to G, chromosome 19 at 10,918,577 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1279 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039345-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.