Strain Name:
C57BL/6J-MtgxR1292Btlr/Mmmh
Stock Number:
039358-MU
Citation ID:
RRID:MMRRC_039358-MU
Other Names:
R1292 (G1), C57BL/6J-MtgxR1292Btlr
Major Collection:

Gene Information

Ctbp2
Name: C-terminal binding protein 2
Synonyms: Ribeye, D7Ertd45e, Gtrgeo6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13017
HGNC: HGNC:2495
Homologene: 75187
Clcnka
Name: chloride channel, voltage-sensitive Ka
Synonyms: CLC-K1, Clcnk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 12733
Homologene: 65
Plxnd1
Name: plexin D1
Synonyms: 6230425C21Rik, b2b553Clo, b2b1863Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67784
HGNC: HGNC:9107
Homologene: 22866
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, HTRX1, ALL-1, All1, Cxxc7, Mll, Mll1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Prss16
Name: protease, serine 16 (thymus)
Synonyms: TSSP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 54373
HGNC: HGNC:9480
Homologene: 38106
Tln1
Name: talin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 21894
Homologene: 21267
Srsf6
Name: serine and arginine-rich splicing factor 6
Synonyms: 1210001E11Rik, Sfrs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 67996
Homologene: 110783
Jag1
Name: jagged 1
Synonyms: Serrate-1, Headturner, Htu, ABE2, Ozz, Gsfabe2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16449
HGNC: HGNC:6188
Homologene: 180
Atp8b1
Name: ATPase, class I, type 8B, member 1
Synonyms: FIC1, Ic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 54670
VEGA: 18
HGNC: HGNC:3706
Homologene: 21151
Zfp458
Name: zinc finger protein 458
Synonyms: Rslcan-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238690
VEGA: 13
Homologene: 128170
9530053A07Rik
Name: RIKEN cDNA 9530053A07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 319482
Homologene: 130055
Rhbdl2
Name: rhomboid like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230726
Homologene: 49508
Gm10036
Name: predicted gene 10036
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 100040551
VEGA: 18
Pcdhb13
Name: protocadherin beta 13
Synonyms: PcdhbM, Pcdbh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
Slc2a2
Name: solute carrier family 2 (facilitated glucose transporter), member 2
Synonyms: liver-type glucose transporter, Glut-2, Glut2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20526
Homologene: 68047
Pik3ca
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
Synonyms: p110alpha, caPI3K, 6330412C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 18706
HGNC: HGNC:8975
Homologene: 21249
Mmut
Name: methylmalonyl-Coenzyme A mutase
Synonyms: D230010K02Rik, Mut
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17850
VEGA: 17
HGNC: HGNC:7526
Homologene: 20097
Olfr231
Name: olfactory receptor 231
Synonyms: GA_x6K02T2P20D-21053942-21054499, GA_x6K02T2LER7-6-623, GA_x6K02T02K39-452-3, MOR105-4, Olfr425, Olfr244
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 404222
Homologene: 17363
Cnga1
Name: cyclic nucleotide gated channel alpha 1
Synonyms: Cncg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12788
HGNC: HGNC:2148
Homologene: 55432
Igfbp1
Name: insulin-like growth factor binding protein 1
Synonyms: IGFBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16006
HGNC: HGNC:5469
Homologene: 498
4930550C14Rik
Name: RIKEN cDNA 4930550C14 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 75311
VEGA: 9
Homologene: 12595
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: IIIAm1, Cyp3a, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Cma2
Name: chymase 2, mast cell
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 545055
VEGA: 14
Homologene: 115745
Abcb1a
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1A
Synonyms: mdr-3, Mdr1a, P-gp, P-glycoprotein, Pgy-3, Pgy3, multiple drug resistant 1a, MDR3, Pgp, Evi32
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18671
HGNC: HGNC:40
Homologene: 55496
Tacr1
Name: tachykinin receptor 1
Synonyms: neurokinin receptor 1, NK-1R, NK1-R, NK1 receptor, Tac1r, substance p receptor, SPr
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 21336
Homologene: 20288
Ly9
Name: lymphocyte antigen 9
Synonyms: T100, Lgp100, CD229, SLAMF3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Olfr180
Name: olfactory receptor 180
Synonyms: GA_x54KRFPKG5P-55134972-55134019, MOR184-9, MOR184-11P, MOR184-11P, Olfr1563-ps1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 258178
Homologene: 79337
Defb40
Name: defensin beta 40
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 360217
Homologene: 86851
Vdac3-ps1
Name: voltage-dependent anion channel 3, pseudogene 1
Synonyms: ENSMUSG00000075053
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 22336
VEGA: 13
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 171,589,103 bp
  • A to G, chromosome 1 at 174,117,854 bp
  • C to G, chromosome 2 at 137,083,473 bp
  • C to T, chromosome 2 at 162,934,483 bp
  • C to T, chromosome 3 at 28,717,488 bp
  • T to A, chromosome 3 at 32,454,420 bp
  • A to G, chromosome 4 at 43,534,578 bp
  • G to A, chromosome 4 at 123,829,642 bp
  • A to G, chromosome 4 at 141,395,592 bp
  • A to T, chromosome 5 at 8,713,343 bp
  • T to C, chromosome 5 at 72,604,683 bp
  • T to C, chromosome 5 at 145,865,994 bp
  • A to G, chromosome 6 at 82,554,875 bp
  • T to C, chromosome 6 at 115,962,683 bp
  • A to C, chromosome 7 at 28,142,794 bp
  • A to T, chromosome 7 at 56,197,203 bp
  • T to A, chromosome 7 at 133,015,189 bp
  • A to C, chromosome 8 at 18,978,064 bp
  • A to T, chromosome 9 at 44,814,694 bp
  • T to A, chromosome 9 at 53,425,619 bp
  • A to G, chromosome 11 at 7,200,863 bp
  • T to C, chromosome 13 at 18,031,295 bp
  • T to A, chromosome 13 at 22,009,521 bp
  • A to T, chromosome 13 at 67,256,690 bp
  • C to T, chromosome 14 at 55,973,742 bp
  • C to T, chromosome 16 at 58,915,771 bp
  • C to A, chromosome 17 at 40,941,407 bp
  • T to G, chromosome 18 at 15,833,311 bp
  • T to C, chromosome 18 at 37,443,832 bp
  • T to C, chromosome 18 at 64,571,021 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1292 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039358-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.