Strain Name:
C57BL/6J-MtgxR1326Btlr/Mmmh
Stock Number:
039392-MU
Citation ID:
RRID:MMRRC_039392-MU
Other Names:
R1326 (G1), C57BL/6J-MtgxR1326Btlr
Major Collection:

Gene Information

Map2k5
Name: mitogen-activated protein kinase kinase 5
Synonyms: MEK5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 23938
VEGA: 9
HGNC: HGNC:6845
Homologene: 115933
Fezf2
Name: Fez family zinc finger 2
Synonyms: forebrain embryonic zinc finger, Fez, Fezl, Zfp312
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 54713
VEGA: 14
Homologene: 9957
Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Hspa4
Name: heat shock protein 4
Synonyms: APG-2, Hsp70RY, Hsp110, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Parp1
Name: poly (ADP-ribose) polymerase family, member 1
Synonyms: PARP, sPARP-1, Adprp, parp-1, 5830444G22Rik, Adprt1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 11545
HGNC: HGNC:270
Homologene: 1222
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 70427
Homologene: 18941
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Atp13a3
Name: ATPase type 13A3
Synonyms: LOC224088, LOC224087, LOC385637
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 224088
Homologene: 23455
Hspd1
Name: heat shock protein 1 (chaperonin)
Synonyms: Hsp60
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 15510
HGNC: HGNC:5261
Homologene: 1626
Pa2g4
Name: proliferation-associated 2G4
Synonyms: Plfap, Ebp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18813
HGNC: HGNC:8550
Homologene: 4513
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20660
Homologene: 2336
Armc3
Name: armadillo repeat containing 3
Synonyms: 4921513G22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70882
Homologene: 31589
Slc27a2
Name: solute carrier family 27 (fatty acid transporter), member 2
Synonyms: FATP2, VLCS, FATP2, Vlacs, Vlac, ACSVL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 26458
Homologene: 37830
Rin2
Name: Ras and Rab interactor 2
Synonyms: RASSF4, 4632403N06Rik, 2010003K16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 74030
Homologene: 32430
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: Gm10331, C330021H03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190-B, p190B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Col9a1
Name: collagen, type IX, alpha 1
Synonyms: Col9a-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12839
HGNC: HGNC:2217
Homologene: 1393
Moxd2
Name: monooxygenase, DBH-like 2
Synonyms: Dbhl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 194357
Homologene: 77226
Slc1a4
Name: solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Synonyms: ASCT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 55963
Homologene: 20655
Map1a
Name: microtubule-associated protein 1 A
Synonyms: Mtap-1, Mtap1, 6330416M19Rik, Mtap1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17754
HGNC: HGNC:6835
Homologene: 1778
Spag17
Name: sperm associated antigen 17
Synonyms: 4931427F14Rik, PF6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 74362
Homologene: 52601
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67608
Homologene: 57048
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 71872
Homologene: 70273
Fpgs
Name: folylpolyglutamyl synthetase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14287
HGNC: HGNC:3824
Homologene: 6997
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 76179
Homologene: 44504
Cyp2d9
Name: cytochrome P450, family 2, subfamily d, polypeptide 9
Synonyms: P450-2D, Cyp2d, testosterone 16alpha-hydroxylase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13105
VEGA: 15
HGNC: HGNC:2625
Homologene: 86099
Fsbp
Name: fibrinogen silencer binding protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100503583
Homologene: 132087
Ifna7
Name: interferon alpha 7
Synonyms: Ifa7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 15970
Homologene: 68536
Errfi1
Name: ERBB receptor feedback inhibitor 1
Synonyms: 1300002F13Rik, Mig-6, RALT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74155
Homologene: 10344
Tmem71
Name: transmembrane protein 71
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 213068
VEGA: 15
Homologene: 51638
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 24,222,004 bp
  • G to T, chromosome 1 at 26,683,930 bp
  • T to C, chromosome 1 at 55,080,259 bp
  • T to C, chromosome 1 at 58,231,257 bp
  • T to A, chromosome 1 at 180,600,458 bp
  • T to C, chromosome 2 at 19,310,124 bp
  • T to C, chromosome 2 at 32,692,580 bp
  • C to T, chromosome 2 at 121,306,190 bp
  • T to A, chromosome 2 at 126,564,770 bp
  • C to T, chromosome 2 at 145,860,446 bp
  • T to A, chromosome 3 at 100,054,886 bp
  • A to G, chromosome 4 at 11,579,891 bp
  • A to G, chromosome 4 at 18,054,517 bp
  • A to T, chromosome 4 at 88,816,694 bp
  • T to C, chromosome 4 at 150,865,164 bp
  • T to C, chromosome 6 at 40,880,354 bp
  • G to C, chromosome 7 at 121,648,302 bp
  • A to G, chromosome 9 at 42,031,796 bp
  • A to G, chromosome 9 at 63,216,981 bp
  • C to T, chromosome 9 at 118,484,497 bp
  • C to T, chromosome 10 at 18,165,542 bp
  • A to G, chromosome 10 at 79,544,709 bp
  • T to C, chromosome 10 at 128,559,273 bp
  • A to G, chromosome 11 at 20,332,159 bp
  • T to C, chromosome 11 at 53,262,439 bp
  • T to A, chromosome 11 at 121,242,553 bp
  • G to A, chromosome 12 at 52,518,370 bp
  • G to A, chromosome 13 at 11,737,717 bp
  • T to C, chromosome 14 at 12,342,644 bp
  • A to G, chromosome 15 at 66,527,946 bp
  • T to C, chromosome 15 at 82,455,156 bp
  • G to A, chromosome 16 at 30,352,310 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1326 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039392-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.