Strain Name:
C57BL/6J-MtgxR1335Btlr/Mmmh
Stock Number:
039400-MU
Citation ID:
RRID:MMRRC_039400-MU
Other Names:
R1335 (G1), C57BL/6J-MtgxR1335Btlr
Major Collection:

Strain Information

Ndrg3
Name: N-myc downstream regulated gene 3
Synonyms: Ndr3, 4833415O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 29812
Homologene: 40903
Scarb2
Name: scavenger receptor class B, member 2
Synonyms: LIMP II, LGP85, Cd36l2, LIMP-2, 9330185J12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12492
HGNC: HGNC:1665
Homologene: 48353
Eprs
Name: glutamyl-prolyl-tRNA synthetase
Synonyms: 3010002K18Rik, 2410081F06Rik, Qprs
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Cdh9
Name: cadherin 9
Synonyms: T1-cadherin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 12565
HGNC: HGNC:1768
Homologene: 9450
Phf24
Name: PHD finger protein 24
Synonyms: N28178, GINIP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230085
Homologene: 18208
Galnt14
Name: polypeptide N-acetylgalactosaminyltransferase 14
Synonyms: 0610033M06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71685
Homologene: 56997
Amph
Name: amphiphysin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Cd209d
Name: CD209d antigen
Synonyms: SIGNR3, mSIGNR3, SIGN-R3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170779
HGNC: HGNC:1641
Homologene: 8603
Smco2
Name: single-pass membrane protein with coiled-coil domains 2
Synonyms: 1700023A16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69371
Homologene: 106211
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 21960
Homologene: 124416
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 192190
Homologene: 16332
Mcoln2
Name: mucolipin 2
Synonyms: 3300002C04Rik, mucolipidin 2, TRPML2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 68279
Homologene: 12258
Stard9
Name: START domain containing 9
Synonyms: N-3 kinesin, Kif16a, 4831403C07Rik, E230025N21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 668880
Homologene: 130712
Slco1c1
Name: solute carrier organic anion transporter family, member 1c1
Synonyms: OATP-F, Slc21a14
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 58807
Homologene: 23008
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mdga2, 9330209L04Rik, 6720489L24Rik, Mamdc1, Adp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 320772
Homologene: 45659
Gpr141
Name: G protein-coupled receptor 141
Synonyms: Pgr13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 353346
VEGA: 13
Homologene: 18771
Simc1
Name: SUMO-interacting motifs containing 1
Synonyms: 4732471D19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 319719
Homologene: 131217
Vmn1r30
Name: vomeronasal 1 receptor 30
Synonyms: V1rc9, V1rc22
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171195
Homologene: 137652
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93888
Homologene: 81881
Prss51
Name: protease, serine 51
Synonyms: 1700007N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 100504162
Homologene: 131540
Sytl4
Name: synaptotagmin-like 4
Synonyms: granuphilin-b, granuphilin-a, Slp4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 27359
Homologene: 8454
Or2l13
Name: olfactory receptor family 2 subfamily L member 13
Synonyms: GA_x54KRFPKG5P-15934912-15935850, MOR270-1, Olfr166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 259071
Homologene: 88350
AC132379.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Zdhhc16
Name: zinc finger, DHHC domain containing 16
Synonyms: APH2, 1500015N03Rik, Abl-philin 2, Ablphilin 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 74168
VEGA: 19
Homologene: 11377
Bid
Name: BH3 interacting domain death agonist
Synonyms: 2700049M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12122
HGNC: HGNC:1050
Homologene: 923
Mtarc1
Name: mitochondrial amidoxime reducing component 1
Synonyms: 1300013F15Rik, Mosc1, Marc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66112
Homologene: 129604
Ivd
Name: isovaleryl coenzyme A dehydrogenase
Synonyms: 6720455E18Rik, 1300016K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56357
HGNC: HGNC:6186
Homologene: 1676
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 20,571,405 bp
  • A to G, chromosome 1 at 116,804,619 bp
  • A to G, chromosome 1 at 159,868,030 bp
  • C to T, chromosome 1 at 184,803,941 bp
  • T to A, chromosome 1 at 185,387,089 bp
  • A to T, chromosome 2 at 118,869,442 bp
  • C to A, chromosome 2 at 120,673,636 bp
  • T to C, chromosome 2 at 156,946,008 bp
  • A to G, chromosome 3 at 146,180,174 bp
  • G to A, chromosome 4 at 42,934,657 bp
  • C to T, chromosome 5 at 92,451,346 bp
  • A to G, chromosome 6 at 58,435,095 bp
  • C to T, chromosome 6 at 120,897,255 bp
  • T to A, chromosome 6 at 141,542,127 bp
  • T to C, chromosome 6 at 146,862,087 bp
  • T to A, chromosome 8 at 3,872,027 bp
  • A to G, chromosome 12 at 35,132,124 bp
  • T to C, chromosome 12 at 66,716,742 bp
  • T to C, chromosome 12 at 111,296,441 bp
  • G to A, chromosome 13 at 19,142,028 bp
  • T to G, chromosome 13 at 19,751,864 bp
  • ACCA to ACCANNNNNNNNNNNNNNNNNNCCA, chromosome 13 at 54,525,265 bp
  • C to T, chromosome 13 at 93,041,535 bp
  • T to G, chromosome 14 at 64,096,171 bp
  • T to C, chromosome 15 at 16,850,792 bp
  • G to A, chromosome 15 at 44,505,547 bp
  • T to C, chromosome 16 at 19,487,053 bp
  • T to A, chromosome 17 at 73,526,290 bp
  • A to T, chromosome 18 at 37,486,234 bp
  • T to A, chromosome 19 at 41,940,634 bp
  • GAAAAAA to GAAAAA, chromosome X at 133,961,126 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1335 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039400-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.