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Strain Name:
C57BL/6J-MtgxR1370Btlr/Mmmh
Stock Number:
039434-MU
Citation ID:
RRID:MMRRC_039434-MU
Other Names:
R1370 (G1), C57BL/6J-MtgxR1370Btlr
Major Collection:

Strain Information

Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik, D630049N15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Ndrg3
Name: N-myc downstream regulated gene 3
Synonyms: Ndr3, 4833415O14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29812
Homologene: 40903
Tbcel
Name: tubulin folding cofactor E-like
Synonyms: E130107N23Rik, Lrrc35
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272589
Homologene: 16120
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849
Cryzl1
Name: crystallin zeta like 1
Synonyms: 2210407J23Rik, 2410006O11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66609
HGNC: HGNC:2420
Homologene: 3749
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21, 2610202A04Rik, D16Ium21e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Clptm1
Name: cleft lip and palate associated transmembrane protein 1
Synonyms: N14, HS9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56457
HGNC: HGNC:2087
Homologene: 37464
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 37,835,453 bp
  • A to G, chromosome 1 at 80,540,343 bp
  • A to T, chromosome 1 at 89,143,772 bp
  • A to T, chromosome 1 at 91,445,557 bp
  • G to T, chromosome 1 at 93,499,106 bp
  • A to C, chromosome 1 at 98,423,094 bp
  • C to T, chromosome 1 at 161,032,022 bp
  • A to T, chromosome 2 at 69,881,420 bp
  • G to T, chromosome 2 at 76,847,151 bp
  • T to C, chromosome 2 at 120,697,477 bp
  • A to G, chromosome 2 at 120,719,139 bp
  • A to T, chromosome 2 at 139,732,074 bp
  • A to G, chromosome 2 at 143,065,166 bp
  • T to C, chromosome 2 at 156,938,650 bp
  • G to T, chromosome 3 at 14,548,114 bp
  • T to C, chromosome 3 at 33,826,480 bp
  • A to G, chromosome 3 at 92,707,843 bp
  • C to T, chromosome 3 at 96,651,738 bp
  • T to C, chromosome 3 at 144,813,863 bp
  • C to A, chromosome 3 at 154,243,159 bp
  • T to A, chromosome 4 at 86,811,510 bp
  • T to A, chromosome 4 at 143,795,304 bp
  • T to A, chromosome 4 at 155,075,624 bp
  • A to T, chromosome 5 at 33,778,682 bp
  • A to G, chromosome 5 at 35,935,600 bp
  • T to C, chromosome 5 at 49,960,787 bp
  • G to T, chromosome 5 at 53,200,217 bp
  • C to T, chromosome 5 at 105,016,576 bp
  • C to T, chromosome 5 at 123,160,685 bp
  • T to C, chromosome 5 at 146,470,208 bp
  • T to A, chromosome 6 at 43,283,912 bp
  • T to A, chromosome 6 at 48,448,626 bp
  • A to G, chromosome 6 at 87,981,151 bp
  • A to T, chromosome 6 at 122,561,185 bp
  • G to A, chromosome 6 at 125,036,453 bp
  • A to T, chromosome 6 at 137,057,801 bp
  • A to G, chromosome 7 at 19,633,872 bp
  • A to G, chromosome 7 at 43,776,907 bp
  • T to A, chromosome 7 at 56,168,873 bp
  • T to C, chromosome 7 at 118,159,752 bp
  • T to A, chromosome 7 at 127,879,864 bp
  • A to T, chromosome 8 at 27,227,770 bp
  • C to T, chromosome 8 at 123,962,052 bp
  • T to C, chromosome 8 at 126,448,330 bp
  • A to T, chromosome 9 at 42,450,062 bp
  • T to C, chromosome 9 at 52,678,008 bp
  • A to G, chromosome 10 at 103,028,492 bp
  • A to G, chromosome 10 at 108,690,922 bp
  • A to G, chromosome 10 at 128,388,696 bp
  • T to G, chromosome 11 at 29,833,085 bp
  • G to A, chromosome 11 at 43,151,655 bp
  • A to G, chromosome 11 at 50,815,840 bp
  • G to T, chromosome 11 at 83,188,806 bp
  • A to T, chromosome 11 at 107,047,094 bp
  • A to G, chromosome 11 at 120,485,301 bp
  • A to G, chromosome 12 at 26,471,452 bp
  • A to T, chromosome 12 at 112,961,108 bp
  • C to T, chromosome 12 at 119,171,003 bp
  • A to G, chromosome 14 at 76,437,664 bp
  • A to T, chromosome 14 at 87,458,054 bp
  • A to G, chromosome 14 at 88,468,301 bp
  • A to C, chromosome 15 at 73,540,854 bp
  • T to C, chromosome 15 at 101,677,552 bp
  • T to A, chromosome 16 at 33,975,584 bp
  • A to G, chromosome 16 at 59,201,680 bp
  • A to G, chromosome 16 at 62,919,558 bp
  • A to T, chromosome 16 at 89,898,221 bp
  • A to G, chromosome 16 at 91,692,658 bp
  • A to G, chromosome 16 at 94,418,637 bp
  • G to A, chromosome 17 at 17,387,480 bp
  • A to G, chromosome 17 at 25,776,988 bp
  • A to T, chromosome 17 at 56,064,032 bp
  • T to C, chromosome 17 at 58,974,087 bp
  • A to G, chromosome 18 at 32,429,703 bp
  • T to A, chromosome 18 at 89,247,023 bp
  • A to G, chromosome 19 at 39,740,956 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1370 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039434-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.