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Strain Name:
C57BL/6J-MtgxR1381Btlr/Mmmh
Stock Number:
039443-MU
Citation ID:
RRID:MMRRC_039443-MU
Other Names:
R1381 (G1), C57BL/6J-MtgxR1381Btlr
Major Collection:

Strain Information

Agtrap
Name: angiotensin II, type I receptor-associated protein
Synonyms: Atrap, D4Wsu124e, 3300002E14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11610
Homologene: 7621
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75914
Homologene: 44781
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Ptcd2
Name: pentatricopeptide repeat domain 2
Synonyms: 1190005P08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68927
VEGA: 13
Homologene: 11695
Drosha
Name: drosha, ribonuclease type III
Synonyms: 1110013A17Rik, Etohi2, Rnasen
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Fdft1
Name: farnesyl diphosphate farnesyl transferase 1
Synonyms: squalene synthase, SQS, Ss
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14137
VEGA: 14
HGNC: HGNC:3629
Homologene: 3281
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 55,003,154 bp
  • C to T, chromosome 1 at 66,720,904 bp
  • T to A, chromosome 1 at 130,419,675 bp
  • T to C, chromosome 1 at 143,635,100 bp
  • T to A, chromosome 2 at 52,260,532 bp
  • C to A, chromosome 2 at 68,731,086 bp
  • T to C, chromosome 2 at 87,803,136 bp
  • A to C, chromosome 2 at 128,877,379 bp
  • A to G, chromosome 2 at 130,635,299 bp
  • A to T, chromosome 2 at 155,814,127 bp
  • G to A, chromosome 2 at 178,420,425 bp
  • A to T, chromosome 3 at 60,039,930 bp
  • A to T, chromosome 3 at 68,914,783 bp
  • A to T, chromosome 3 at 93,826,140 bp
  • C to T, chromosome 3 at 115,956,870 bp
  • G to A, chromosome 4 at 33,081,420 bp
  • T to C, chromosome 4 at 41,118,880 bp
  • T to A, chromosome 4 at 43,416,137 bp
  • C to A, chromosome 4 at 48,421,942 bp
  • C to A, chromosome 4 at 49,337,674 bp
  • A to C, chromosome 4 at 53,785,999 bp
  • G to A, chromosome 4 at 86,774,532 bp
  • A to T, chromosome 4 at 98,779,938 bp
  • T to C, chromosome 4 at 102,604,965 bp
  • G to T, chromosome 4 at 117,889,668 bp
  • T to G, chromosome 4 at 117,904,395 bp
  • T to A, chromosome 4 at 123,289,059 bp
  • G to A, chromosome 4 at 148,083,965 bp
  • G to T, chromosome 5 at 30,128,836 bp
  • T to A, chromosome 5 at 57,721,540 bp
  • G to A, chromosome 5 at 88,665,864 bp
  • A to T, chromosome 5 at 105,081,116 bp
  • A to T, chromosome 5 at 143,362,651 bp
  • A to T, chromosome 6 at 12,555,439 bp
  • T to A, chromosome 6 at 15,409,766 bp
  • T to C, chromosome 6 at 66,636,938 bp
  • T to C, chromosome 6 at 84,835,117 bp
  • C to A, chromosome 6 at 91,075,960 bp
  • T to C, chromosome 6 at 94,606,130 bp
  • T to A, chromosome 6 at 123,786,733 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to G, chromosome 6 at 146,588,741 bp
  • A to G, chromosome 7 at 6,481,009 bp
  • A to G, chromosome 7 at 35,776,010 bp
  • A to T, chromosome 7 at 41,286,172 bp
  • A to T, chromosome 7 at 43,476,640 bp
  • G to A, chromosome 7 at 43,885,282 bp
  • C to T, chromosome 7 at 47,235,302 bp
  • A to T, chromosome 7 at 127,023,152 bp
  • G to T, chromosome 7 at 127,272,967 bp
  • GCTGCCCAAGTCCC to GC, chromosome 7 at 127,929,849 bp
  • A to G, chromosome 7 at 131,194,351 bp
  • G to T, chromosome 8 at 58,472,955 bp
  • G to A, chromosome 8 at 84,726,526 bp
  • T to A, chromosome 8 at 88,243,309 bp
  • A to G, chromosome 8 at 93,034,031 bp
  • C to A, chromosome 8 at 106,906,276 bp
  • A to C, chromosome 9 at 15,322,565 bp
  • T to A, chromosome 9 at 38,828,338 bp
  • A to G, chromosome 9 at 69,400,527 bp
  • T to A, chromosome 9 at 87,022,233 bp
  • G to A, chromosome 10 at 67,267,826 bp
  • C to A, chromosome 10 at 78,576,596 bp
  • C to T, chromosome 10 at 81,271,756 bp
  • A to T, chromosome 10 at 91,152,618 bp
  • T to C, chromosome 10 at 130,360,691 bp
  • T to A, chromosome 11 at 87,638,169 bp
  • T to C, chromosome 11 at 115,994,337 bp
  • A to T, chromosome 12 at 91,740,492 bp
  • T to C, chromosome 13 at 46,689,181 bp
  • A to C, chromosome 13 at 65,036,554 bp
  • A to G, chromosome 13 at 99,344,597 bp
  • G to T, chromosome 14 at 14,737,363 bp
  • C to A, chromosome 14 at 30,036,834 bp
  • A to T, chromosome 14 at 49,682,758 bp
  • T to A, chromosome 14 at 52,638,510 bp
  • C to A, chromosome 14 at 63,152,508 bp
  • G to T, chromosome 14 at 63,152,511 bp
  • G to T, chromosome 14 at 77,030,966 bp
  • A to T, chromosome 14 at 123,314,105 bp
  • A to G, chromosome 15 at 12,385,439 bp
  • T to C, chromosome 15 at 12,827,301 bp
  • C to A, chromosome 15 at 82,372,508 bp
  • A to T, chromosome 17 at 22,618,486 bp
  • G to A, chromosome 17 at 50,607,729 bp
  • T to A, chromosome 18 at 25,090,471 bp
  • C to T, chromosome 18 at 36,789,217 bp
  • A to G, chromosome 18 at 65,203,960 bp
  • T to C, chromosome 18 at 80,207,264 bp
  • T to G, chromosome 18 at 80,283,314 bp
  • T to C, chromosome 19 at 12,900,956 bp
  • T to C, chromosome 19 at 26,630,828 bp
  • T to A, chromosome 19 at 33,499,341 bp
  • A to G, chromosome 19 at 37,995,485 bp
  • T to C, chromosome 19 at 44,150,463 bp
  • T to C, chromosome X at 113,298,775 bp
  • C to A, chromosome X at 124,128,140 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1381 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039443-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.