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Strain Name:
C57BL/6J-MtgxR1386Btlr/Mmmh
Stock Number:
039448-MU
Citation ID:
RRID:MMRRC_039448-MU
Other Names:
R1386 (G1), C57BL/6J-MtgxR1386Btlr
Major Collection:

Strain Information

Crhr1
Name: corticotropin releasing hormone receptor 1
Synonyms: CRFR1, CRF-R1alpha, CRF 1 receptor, CRF1R
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12921
Homologene: 20920
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: 1110001J02Rik, p110beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Tns3
Name: tensin 3
Synonyms: TEM6, F830010I22Rik, Tens1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319939
Homologene: 49713
Ap2m1
Name: adaptor-related protein complex 2, mu 1 subunit
Synonyms: clathrin-associated AP-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11773
HGNC: HGNC:564
Homologene: 3000
Pmpca
Name: peptidase (mitochondrial processing) alpha
Synonyms: INPP5E, Alpha-MPP, 4933435E07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66865
Homologene: 6078
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: aldosterone synthase, Cyp11b-2, Cyp11b, steroid-11-beta-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13072
Homologene: 128035
Pdss1
Name: prenyl (solanesyl) diphosphate synthase, subunit 1
Synonyms: 2610203G20Rik, 2700031G06Rik, Tprt, mSPS1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56075
Homologene: 5353
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 37,051,881 bp
  • C to T, chromosome 1 at 40,531,522 bp
  • T to A, chromosome 1 at 40,719,018 bp
  • A to G, chromosome 1 at 59,157,510 bp
  • T to C, chromosome 1 at 87,192,590 bp
  • C to A, chromosome 1 at 93,620,151 bp
  • T to C, chromosome 1 at 132,017,830 bp
  • A to G, chromosome 1 at 139,457,623 bp
  • C to T, chromosome 1 at 139,478,972 bp
  • T to G, chromosome 1 at 170,681,162 bp
  • T to C, chromosome 1 at 178,915,644 bp
  • A to G, chromosome 1 at 191,569,717 bp
  • C to T, chromosome 2 at 5,973,461 bp
  • T to A, chromosome 2 at 18,734,246 bp
  • T to A, chromosome 2 at 22,929,536 bp
  • C to T, chromosome 2 at 26,392,518 bp
  • A to G, chromosome 2 at 65,688,741 bp
  • T to C, chromosome 2 at 70,574,123 bp
  • T to C, chromosome 2 at 85,137,461 bp
  • A to G, chromosome 2 at 86,374,921 bp
  • T to A, chromosome 2 at 88,865,353 bp
  • A to C, chromosome 2 at 105,170,017 bp
  • T to A, chromosome 2 at 126,378,744 bp
  • T to C, chromosome 2 at 132,916,058 bp
  • A to G, chromosome 2 at 144,491,831 bp
  • T to C, chromosome 2 at 164,898,241 bp
  • T to C, chromosome 3 at 88,355,671 bp
  • A to G, chromosome 3 at 89,995,849 bp
  • A to T, chromosome 3 at 113,613,784 bp
  • A to T, chromosome 3 at 145,889,211 bp
  • A to G, chromosome 4 at 127,194,926 bp
  • A to T, chromosome 5 at 22,487,224 bp
  • C to T, chromosome 5 at 69,563,162 bp
  • T to A, chromosome 5 at 72,612,183 bp
  • G to A, chromosome 5 at 111,225,677 bp
  • G to A, chromosome 5 at 121,379,652 bp
  • G to A, chromosome 6 at 48,656,653 bp
  • A to T, chromosome 6 at 69,600,105 bp
  • C to G, chromosome 6 at 87,111,524 bp
  • A to G, chromosome 6 at 120,762,131 bp
  • A to C, chromosome 6 at 136,599,646 bp
  • T to C, chromosome 7 at 35,603,540 bp
  • T to C, chromosome 7 at 86,915,407 bp
  • T to A, chromosome 7 at 103,173,367 bp
  • T to C, chromosome 7 at 119,698,578 bp
  • C to A, chromosome 7 at 121,902,488 bp
  • T to A, chromosome 7 at 122,988,592 bp
  • T to C, chromosome 7 at 141,463,568 bp
  • G to T, chromosome 8 at 22,665,617 bp
  • G to A, chromosome 8 at 39,589,293 bp
  • A to T, chromosome 8 at 71,890,662 bp
  • A to T, chromosome 8 at 93,068,077 bp
  • A to G, chromosome 8 at 93,985,399 bp
  • G to A, chromosome 8 at 123,361,366 bp
  • T to A, chromosome 9 at 15,076,754 bp
  • T to A, chromosome 9 at 20,101,582 bp
  • G to T, chromosome 9 at 26,767,063 bp
  • G to A, chromosome 9 at 65,326,888 bp
  • A to T, chromosome 9 at 87,221,202 bp
  • A to G, chromosome 9 at 99,064,027 bp
  • A to T, chromosome 9 at 106,062,945 bp
  • T to C, chromosome 9 at 109,101,023 bp
  • T to A, chromosome 9 at 109,654,641 bp
  • T to A, chromosome 9 at 123,963,962 bp
  • T to C, chromosome 10 at 4,434,818 bp
  • T to A, chromosome 10 at 20,418,801 bp
  • A to T, chromosome 10 at 56,387,969 bp
  • T to C, chromosome 10 at 59,996,457 bp
  • A to T, chromosome 10 at 67,063,009 bp
  • A to T, chromosome 10 at 79,378,711 bp
  • A to G, chromosome 10 at 84,863,285 bp
  • A to G, chromosome 10 at 89,414,353 bp
  • A to T, chromosome 10 at 107,412,122 bp
  • T to A, chromosome 11 at 8,518,261 bp
  • C to T, chromosome 11 at 11,154,262 bp
  • T to C, chromosome 11 at 50,985,367 bp
  • T to A, chromosome 11 at 59,133,853 bp
  • T to C, chromosome 11 at 67,370,950 bp
  • C to T, chromosome 11 at 76,222,003 bp
  • T to C, chromosome 11 at 83,518,825 bp
  • T to C, chromosome 11 at 99,385,920 bp
  • T to C, chromosome 11 at 104,174,394 bp
  • T to C, chromosome 11 at 110,244,255 bp
  • T to A, chromosome 11 at 113,247,724 bp
  • A to T, chromosome 12 at 69,614,658 bp
  • T to A, chromosome 12 at 112,044,804 bp
  • C to T, chromosome 13 at 41,272,692 bp
  • T to C, chromosome 13 at 55,007,030 bp
  • T to C, chromosome 13 at 58,030,433 bp
  • T to C, chromosome 13 at 81,528,865 bp
  • T to A, chromosome 13 at 99,246,555 bp
  • A to G, chromosome 14 at 14,861,544 bp
  • T to A, chromosome 14 at 30,031,434 bp
  • T to C, chromosome 14 at 55,596,764 bp
  • T to A, chromosome 14 at 56,913,091 bp
  • C to A, chromosome 14 at 70,636,770 bp
  • T to C, chromosome 15 at 35,923,312 bp
  • A to G, chromosome 15 at 57,986,503 bp
  • G to T, chromosome 15 at 64,167,841 bp
  • T to A, chromosome 15 at 74,851,775 bp
  • T to G, chromosome 15 at 75,110,589 bp
  • T to G, chromosome 15 at 77,948,521 bp
  • A to G, chromosome 15 at 89,011,386 bp
  • T to C, chromosome 16 at 16,880,629 bp
  • T to G, chromosome 16 at 20,541,229 bp
  • C to A, chromosome 16 at 32,298,963 bp
  • T to G, chromosome 17 at 8,953,742 bp
  • T to C, chromosome 17 at 13,846,536 bp
  • G to A, chromosome 17 at 24,892,918 bp
  • T to A, chromosome 17 at 26,974,638 bp
  • T to A, chromosome 17 at 34,802,210 bp
  • T to C, chromosome 17 at 65,983,380 bp
  • T to A, chromosome 17 at 73,820,543 bp
  • A to T, chromosome 18 at 6,226,383 bp
  • A to T, chromosome 18 at 12,477,370 bp
  • A to T, chromosome 19 at 12,935,139 bp
  • C to T, chromosome X at 79,509,901 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1386 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039448-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.