Strain Name:
C57BL/6J-MtgxR1400Btlr/Mmmh
Stock Number:
039462-MU
Citation ID:
RRID:MMRRC_039462-MU
Other Names:
R1400 (G1), C57BL/6J-MtgxR1400Btlr
Major Collection:

Gene Information

Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, C030040A15Rik, OTTMUSG00000012483
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 109241
Homologene: 81861
Rai14
Name: retinoic acid induced 14
Synonyms: 1700020L11Rik, Ankycorbin, Norpeg, 1700008J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 75646
VEGA: 15
Homologene: 9199
Nudt3
Name: nudix (nucleotide diphosphate linked moiety X)-type motif 3
Synonyms: diphosphoinositol polyphosphate phosphohydrolase, Dipp, 1110011B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 56409
HGNC: HGNC:8050
Homologene: 31400
Cops4
Name: COP9 signalosome subunit 4
Synonyms: COP9 complex S4, D5Ertd774e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26891
Homologene: 8067
Ppm1e
Name: protein phosphatase 1E (PP2C domain containing)
Synonyms: PP2CH, POPX1, B930008A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 320472
Homologene: 22848
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, G431004K08Rik, Gcn1l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Tlr7
Name: toll-like receptor 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 170743
Homologene: 75060
Crygd
Name: crystallin, gamma D
Synonyms: DGcry-1, Cryg-1, Aey4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 12967
HGNC: HGNC:2411
Homologene: 36213
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Acsf2
Name: acyl-CoA synthetase family member 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 264895
Homologene: 23519
Egfl6
Name: EGF-like-domain, multiple 6
Synonyms: Maeg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 54156
HGNC: HGNC:3235
Homologene: 9166
Lifr
Name: LIF receptor alpha
Synonyms: soluble differentiation-stimulating factor receptor, A230075M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Zfp644
Name: zinc finger protein 644
Synonyms: 1110068L01Rik, BM-005, Zep-2, D5Ertd689e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 52397
Homologene: 12971
Golm1
Name: golgi membrane protein 1
Synonyms: D030064E01Rik, PSEC0257, GP73, 2310001L02Rik, Golph2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105348
VEGA: 13
Homologene: 12346
Akap11
Name: A kinase (PRKA) anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Atp6v1c2
Name: ATPase, H+ transporting, lysosomal V1 subunit C2
Synonyms: 1110038G14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 68775
Homologene: 15866
Gcgr
Name: glucagon receptor
Synonyms: GR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14527
HGNC: HGNC:4192
Homologene: 131
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Ndst3
Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
Synonyms: 4930511P15Rik, 4921531K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83398
HGNC: HGNC:7682
Homologene: 3513
Hsh2d
Name: hematopoietic SH2 domain containing
Synonyms: ALX, Hsh2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209488
Homologene: 13142
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75288
Homologene: 45939
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70885
Homologene: 10029
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Cfap44
Name: cilia and flagella associated protein 44
Synonyms: 6330444M21Rik, D16Ertd642e, Wdr52
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 212517
Homologene: 75085
Gbp6
Name: guanylate binding protein 6
Synonyms: Mpa2l
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100702
Homologene: 128731
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 192187
Homologene: 9035
Unc13a
Name: unc-13 homolog A
Synonyms: Munc13-1, 2410078G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382018
Homologene: 11279
Scamp1
Name: secretory carrier membrane protein 1
Synonyms: 4930505M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 107767
Homologene: 37975
Krt13
Name: keratin 13
Synonyms: Krt-1.13, K13, Krt1-13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16663
HGNC: HGNC:6415
Homologene: 40740
Necab1
Name: N-terminal EF-hand calcium binding protein 1
Synonyms: STIP-1, NECAB1, 1700003H21Rik, Efcbp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69352
Homologene: 11172
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: 1600012D06Rik, Abp1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: ojoplano, Opo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Tas2r143
Name: taste receptor, type 2, member 143
Synonyms: mt2r36, Tas2r43
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 387514
Homologene: 74285
Smarca2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms: brm, Snf2l2, 2610209L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67155
Homologene: 2308
Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Synonyms: NIS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 114479
Homologene: 37311
Vill
Name: villin-like
Synonyms: Villp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22351
Homologene: 22650
BC051076
Name: cDNA sequence BC051076
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 243090
Cyp3a11
Name: cytochrome P450, family 3, subfamily a, polypeptide 11
Synonyms: IIIAm1, Cyp3a, Pcn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13112
HGNC: HGNC:2638
Homologene: 133568
Olfr1259
Name: olfactory receptor 1259
Synonyms: GA_x6K02T2Q125-51376062-51375133, MOR232-9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258338
Homologene: 128115
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 446099
Homologene: 75315
Zfp664
Name: zinc finger protein 664
Synonyms: D930038J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 269704
Homologene: 65046
Prkag2
Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit
Synonyms: 2410051C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108099
HGNC: HGNC:9386
Homologene: 136125
9130008F23Rik
Name: RIKEN cDNA 9130008F23 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 71583
VEGA: 17
Homologene: 51919
Cage1
Name: cancer antigen 1
Synonyms: CAGE1, 4933427I01Rik, Ctag3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71213
Homologene: 18484
Olfr1013
Name: olfactory receptor 1013
Synonyms: GA_x6K02T2Q125-47248551-47249468, MOR213-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258757
Homologene: 74096
Fads3
Name: fatty acid desaturase 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 60527
VEGA: 19
HGNC: HGNC:3576
Homologene: 11025
Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
Synonyms: Grf2, 6330417G04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19418
HGNC: HGNC:9876
Homologene: 2169
Ptpn18
Name: protein tyrosine phosphatase, non-receptor type 18
Synonyms: HSCF, FLP1, Ptpk1, PTP-K1, PTP-HSCF
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19253
HGNC: HGNC:9649
Homologene: 74971
Upp2
Name: uridine phosphorylase 2
Synonyms: UDRPASE2, UPASE2, UP2, 1700124F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76654
Homologene: 12654
1700057G04Rik
Name: RIKEN cDNA 1700057G04 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78459
Homologene: 134508
Mzf1
Name: myeloid zinc finger 1
Synonyms: Znf42, Mzf2, Zfp121, Zfp98
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 109889
Homologene: 9633
Micall2
Name: MICAL-like 2
Synonyms: Jrab, MICAL-L2, A930021H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231830
Homologene: 85155
Olfr722
Name: olfactory receptor 722
Synonyms: GA_x6K02T2PMLR-5566715-5565789, MOR241-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258487
Homologene: 17270
Olfr847
Name: olfactory receptor 847
Synonyms: GA_x6K02T2PVTD-13113073-13112135, MOR149-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258518
Homologene: 17281
Thap4
Name: THAP domain containing 4
Synonyms: 2010320B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 67026
Homologene: 12075
Selenon
Name: selenoprotein N
Synonyms: 1110019I12Rik, Sepn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 74777
Homologene: 10723
Rgn
Name: regucalcin
Synonyms: SMP30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 19733
HGNC: HGNC:9989
Homologene: 3437
Las1l
Name: LAS1-like (S. cerevisiae)
Synonyms: 5830482G23Rik, 1810030A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 76130
Homologene: 32746
Nxf3
Name: nuclear RNA export factor 3
Synonyms: LOC245610
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 245610
HGNC: HGNC:8073
Homologene: 19406
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,463,506 bp
  • A to G, chromosome 1 at 65,063,208 bp
  • A to C, chromosome 1 at 93,715,013 bp
  • T to C, chromosome 2 at 49,274,776 bp
  • T to C, chromosome 2 at 58,790,106 bp
  • T to C, chromosome 2 at 85,770,133 bp
  • T to A, chromosome 2 at 89,943,542 bp
  • C to A, chromosome 2 at 180,191,380 bp
  • A to G, chromosome 3 at 123,556,828 bp
  • T to C, chromosome 4 at 14,975,185 bp
  • A to G, chromosome 4 at 134,551,518 bp
  • G to A, chromosome 5 at 24,873,918 bp
  • A to G, chromosome 5 at 87,963,493 bp
  • A to G, chromosome 5 at 100,533,546 bp
  • A to T, chromosome 5 at 105,274,756 bp
  • T to C, chromosome 5 at 106,637,470 bp
  • T to C, chromosome 5 at 115,614,161 bp
  • T to C, chromosome 5 at 124,886,153 bp
  • C to A, chromosome 5 at 139,708,874 bp
  • A to G, chromosome 5 at 145,862,489 bp
  • C to T, chromosome 6 at 42,400,383 bp
  • T to A, chromosome 6 at 48,906,283 bp
  • A to T, chromosome 6 at 48,906,711 bp
  • C to G, chromosome 6 at 52,260,647 bp
  • G to C, chromosome 6 at 52,260,648 bp
  • C to A, chromosome 7 at 13,052,771 bp
  • A to T, chromosome 7 at 23,321,660 bp
  • T to C, chromosome 8 at 68,827,263 bp
  • T to C, chromosome 8 at 70,889,435 bp
  • C to A, chromosome 8 at 71,651,221 bp
  • G to A, chromosome 8 at 72,200,460 bp
  • A to G, chromosome 9 at 19,375,062 bp
  • G to T, chromosome 9 at 92,351,127 bp
  • C to A, chromosome 9 at 95,862,848 bp
  • T to C, chromosome 9 at 119,063,347 bp
  • T to A, chromosome 11 at 87,231,766 bp
  • T to C, chromosome 11 at 94,570,316 bp
  • C to A, chromosome 11 at 100,121,284 bp
  • A to G, chromosome 11 at 120,534,986 bp
  • T to C, chromosome 12 at 17,289,130 bp
  • C to T, chromosome 13 at 11,595,076 bp
  • A to G, chromosome 13 at 38,032,424 bp
  • C to T, chromosome 13 at 40,208,829 bp
  • T to G, chromosome 13 at 59,638,298 bp
  • A to G, chromosome 13 at 67,592,794 bp
  • A to G, chromosome 13 at 91,887,689 bp
  • A to G, chromosome 13 at 94,224,947 bp
  • C to T, chromosome 14 at 31,139,830 bp
  • A to G, chromosome 14 at 49,303,607 bp
  • A to T, chromosome 14 at 49,895,691 bp
  • T to A, chromosome 14 at 78,513,962 bp
  • T to A, chromosome 15 at 7,190,865 bp
  • T to G, chromosome 15 at 10,571,548 bp
  • A to T, chromosome 16 at 44,421,212 bp
  • A to G, chromosome 17 at 27,583,206 bp
  • T to C, chromosome 17 at 40,880,304 bp
  • T to C, chromosome 18 at 58,080,193 bp
  • A to G, chromosome 19 at 10,056,300 bp
  • C to A, chromosome 19 at 26,676,740 bp
  • C to A, chromosome X at 20,550,457 bp
  • T to C, chromosome X at 95,946,900 bp
  • T to A, chromosome X at 136,076,045 bp
  • A to C, chromosome X at 166,523,982 bp
  • T to A, chromosome X at 167,307,849 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1400 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039462-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.