Strain Name:
C57BL/6J-MtgxR1404Btlr/Mmmh
Stock Number:
039466-MU
Citation ID:
RRID:MMRRC_039466-MU
Other Names:
R1404 (G1), C57BL/6J-MtgxR1404Btlr
Major Collection:

Gene Information

Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Khc, D10Bwg0738e, Kif5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Itga6
Name: integrin alpha 6
Synonyms: 5033401O05Rik, Cd49f
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: trabeculin alpha, Aclp7, Acf7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11426
Homologene: 136191
Stx12
Name: syntaxin 12
Synonyms: Stx13, syntaxin 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100226
Homologene: 128192
Stk4
Name: serine/threonine kinase 4
Synonyms: Mst1, Ysk3, Kas-2, sterile 20-like kinase 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 58231
Homologene: 55965
Skp2
Name: S-phase kinase-associated protein 2
Synonyms: FBXL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 27401
Homologene: 55942
Itpr1
Name: inositol 1,4,5-trisphosphate receptor 1
Synonyms: P400, Ip3r, Pcp-1, InsP3R type I, wblo, Pcp1, IP3R1, opt, Itpr-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16438
HGNC: HGNC:6180
Homologene: 1673
Abca1
Name: ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms: ABC1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11303
HGNC: HGNC:29
Homologene: 21130
Arrdc3
Name: arrestin domain containing 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 105171
Homologene: 69318
Actl6a
Name: actin-like 6A
Synonyms: Baf53a, Actl6, 2810432C06Rik, ARP4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 56456
Homologene: 55811
Ttn
Name: titin
Synonyms: mdm, 2310036G12Rik, D830007G01Rik, connectin, 1100001C23Rik, shru, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fam151b
Name: family with sequence similarity 151, member B
Synonyms: 4930405M20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 73942
VEGA: 13
Homologene: 17853
Nell1
Name: NEL-like 1
Synonyms: B230343H07Rik, l7R6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 338352
HGNC: HGNC:7750
Homologene: 4486
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Cdh8
Name: cadherin 8
Synonyms: cad8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12564
HGNC: HGNC:1767
Homologene: 55604
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Birc1b, Naip2, Naip-rs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Neb
Name: nebulin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Ncdn
Name: neurochondrin
Synonyms: neurochondrin-2, norbin, neurochondrin-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 26562
Homologene: 8064
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213043
Homologene: 84622
Ihh
Name: Indian hedgehog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16147
HGNC: HGNC:5956
Homologene: 22586
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Spink14
Name: serine peptidase inhibitor, Kazal type 14
Synonyms: Gm5505
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 433178
Homologene: 37400
Fam227b
Name: family with sequence similarity 227, member B
Synonyms: 4930525F21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75823
Homologene: 27384
Sfi1
Name: Sfi1 homolog, spindle assembly associated (yeast)
Synonyms: 2310047I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78887
Homologene: 12707
Spag16
Name: sperm associated antigen 16
Synonyms: 4930585K05Rik, Pf20, 4930524F24Rik, 4921511D23Rik, Wdr29
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66722
Homologene: 11572
Lpin3
Name: lipin 3
Synonyms: 9130206L11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 64899
Homologene: 84844
Ces5a
Name: carboxylesterase 5A
Synonyms: 1700081L16Rik, LOC244598, 1700122C07Rik, cauxin, Ces7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67935
Homologene: 74305
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244668
Homologene: 18956
Gm17535
Name: predicted gene, 17535
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Zfp202
Name: zinc finger protein 202
Synonyms: C130037E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 80902
Homologene: 68317
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 207742
Homologene: 37742
Tmc1
Name: transmembrane channel-like gene family 1
Synonyms: Bth, Beethoven, 4933416G09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 13409
VEGA: 19
Homologene: 23670
Sardh
Name: sarcosine dehydrogenase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 192166
Homologene: 5149
Doxl2
Name: diamine oxidase-like protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 243376
Homologene: 19443
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: EG637898, Gprc2a-rs3, Casr-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 637898
Homologene: 129683
Sel1l2
Name: sel-1 suppressor of lin-12-like 2 (C. elegans)
Synonyms: LOC228684
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228684
Homologene: 16802
Dync1i1
Name: dynein cytoplasmic 1 intermediate chain 1
Synonyms: IC74, Dncic1, DIC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13426
HGNC: HGNC:2963
Homologene: 68398
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101613
Homologene: 15881
Bbs2
Name: Bardet-Biedl syndrome 2 (human)
Synonyms: 2410125H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Olfr1317
Name: olfactory receptor 1317
Synonyms: MOR245-4, GA_x6K02T2Q125-73188162-73189112
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258440
Homologene: 71983
Tollip
Name: toll interacting protein
Synonyms: 4931428G15Rik, Toll interacting protein, 4930403G24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54473
Homologene: 10375
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,346,212 bp
  • G to A, chromosome 1 at 69,895,280 bp
  • A to T, chromosome 1 at 74,951,213 bp
  • C to A, chromosome 2 at 27,239,461 bp
  • C to T, chromosome 2 at 52,183,275 bp
  • A to G, chromosome 2 at 71,838,716 bp
  • A to T, chromosome 2 at 76,812,968 bp
  • G to A, chromosome 2 at 112,142,623 bp
  • A to G, chromosome 2 at 126,003,839 bp
  • C to T, chromosome 2 at 140,230,059 bp
  • T to A, chromosome 2 at 160,892,390 bp
  • C to T, chromosome 2 at 164,100,528 bp
  • T to C, chromosome 3 at 32,722,610 bp
  • G to A, chromosome 4 at 53,059,253 bp
  • T to A, chromosome 4 at 123,376,516 bp
  • T to C, chromosome 4 at 126,750,040 bp
  • T to A, chromosome 4 at 132,871,649 bp
  • G to A, chromosome 6 at 5,915,876 bp
  • A to T, chromosome 6 at 48,975,833 bp
  • T to A, chromosome 6 at 108,386,648 bp
  • T to A, chromosome 7 at 42,136,787 bp
  • T to A, chromosome 7 at 50,853,873 bp
  • GAGAAGAAGAAGAAGAAGAAGA to GAGAAGAAGAAGAAGAAGA, chromosome 7 at 140,924,113 bp
  • T to C, chromosome 7 at 141,884,555 bp
  • A to T, chromosome 8 at 93,502,181 bp
  • T to C, chromosome 8 at 94,081,999 bp
  • A to T, chromosome 8 at 99,279,618 bp
  • G to A, chromosome 8 at 125,449,973 bp
  • A to G, chromosome 9 at 3,035,804 bp
  • C to T, chromosome 9 at 40,211,496 bp
  • A to G, chromosome 10 at 39,061,391 bp
  • T to C, chromosome 10 at 127,245,442 bp
  • TCGC to TC, chromosome 11 at 3,146,254 bp
  • CCTCTC to CCTCTCTC, chromosome 11 at 3,177,419 bp
  • A to G, chromosome 11 at 87,734,177 bp
  • A to G, chromosome 13 at 80,883,854 bp
  • T to C, chromosome 13 at 92,473,972 bp
  • T to C, chromosome 13 at 100,161,854 bp
  • T to C, chromosome 14 at 79,026,031 bp
  • G to A, chromosome 15 at 9,116,925 bp
  • A to G, chromosome 18 at 44,028,829 bp
  • T to A, chromosome 19 at 20,816,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1404 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039466-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.