Strain Name:
C57BL/6J-MtgxR1422Btlr/Mmmh
Stock Number:
039478-MU
Citation ID:
RRID:MMRRC_039478-MU
Other Names:
R1422 (G1), C57BL/6J-MtgxR1422Btlr
Major Collection:

Gene Information

Atrn
Name: attractin
Synonyms: Mgca
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 11990
HGNC: HGNC:885
Homologene: 22542
Becn1
Name: beclin 1, autophagy related
Synonyms: Atg6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 56208
HGNC: HGNC:1034
Homologene: 2794
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Ggtb3, Alfy, 2610509D04Rik, Bchs, Bwf1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72145
Homologene: 22855
Trp53bp2
Name: transformation related protein 53 binding protein 2
Synonyms: ASPP2, 53BP2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 209456
Homologene: 3959
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: MmRad24, 9430035O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Fgd6
Name: FYVE, RhoGEF and PH domain containing 6
Synonyms: Etohd4, ZFYVE24
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 13998
Homologene: 14209
Robo2
Name: roundabout guidance receptor 2
Synonyms: 2600013A04Rik, 9430089E08Rik, D230004I22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 268902
Homologene: 43188
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: DNA mismatch repair, mismatch repair
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 18861
HGNC: HGNC:9122
Homologene: 133560
Plk2
Name: polo like kinase 2
Synonyms: Snk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 20620
VEGA: 13
Homologene: 21317
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: ELM2, Ten-m4, Odz4, Doc4, l7Rn3, l(7)-3Rn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 23966
Homologene: 8034
Macrod2
Name: mono-ADP ribosylhydrolase 2
Synonyms: 1110033L15Rik, 2610107G07Rik, 2900006F19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 72899
Homologene: 85987
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: VIa, A730020P05Rik, Sema6A-1, sema, Semaq
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20358
Homologene: 32426
Hk1
Name: hexokinase 1
Synonyms: mHk1-s, Hk-1, Hk1-s
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 15275
HGNC: HGNC:4922
Homologene: 100530
Dpy19l4
Name: dpy-19-like 4 (C. elegans)
Synonyms: Narg3, LOC381510
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381510
Homologene: 18773
Ttn
Name: titin
Synonyms: D830007G01Rik, connectin, 1100001C23Rik, 2310036G12Rik, mdm, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru, L56
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Mmrn2
Name: multimerin 2
Synonyms: ENDOGLYX1, Emilin3, EndoGlyx-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 105450
VEGA: 14
Homologene: 11697
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244646
Homologene: 14627
Ptpro
Name: protein tyrosine phosphatase, receptor type, O
Synonyms: PTP-BK, Ptpn15, PTP-U2, PTP-oc, PTP-phi, GLEPP1, PTPROt, D28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
4931408C20Rik
Name: RIKEN cDNA 4931408C20 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 210940
Homologene: 86827
Arhgap5
Name: Rho GTPase activating protein 5
Synonyms: p190B, p190-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 11855
VEGA: 12
HGNC: HGNC:675
Homologene: 907
Spock3
Name: sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
Synonyms: testican 3, 2900045C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 72902
Homologene: 9662
Olfr124
Name: olfactory receptor 124
Synonyms: GA_x6K02T2PSCP-2264806-2265753, MOR256-3, A3, SR1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 259064
Homologene: 74266
Gria1
Name: glutamate receptor, ionotropic, AMPA1 (alpha 1)
Synonyms: HIPA1, GluRA, Glur1, GluA1, Glur-1, GluR1, Glr1, GluR-A, Glr-1, 2900051M01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14799
HGNC: HGNC:4571
Homologene: 20226
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Ctns
Name: cystinosis, nephropathic
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 83429
HGNC: HGNC:2518
Homologene: 3625
Slc6a19
Name: solute carrier family 6 (neurotransmitter transporter), member 19
Synonyms: 4632401C08Rik, B0AT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 74338
Homologene: 52819
Zfp366
Name: zinc finger protein 366
Synonyms: DC-SCRIPT
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 238803
Homologene: 17637
AC139206.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 76482
Homologene: 8341
Gm17535
Name: predicted gene, 17535
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Kif19a
Name: kinesin family member 19A
Synonyms: N-8 kinesin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 286942
Homologene: 17709
Dtx3
Name: deltex 3, E3 ubiquitin ligase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 80904
Homologene: 12754
Olfr1156
Name: olfactory receptor 1156
Synonyms: MOR174-3, GA_x6K02T2Q125-49433499-49432537
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258814
HGNC: HGNC:8351
Homologene: 72031
Ift88
Name: intraflagellar transport 88
Synonyms: IFT88, TgN737Rpw, Tg737, orpk, Oak Ridge polycystic kidneys, Ttc10, fxo, Tg737Rpw, polaris
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21821
Homologene: 4761
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 4930438C08Rik, 3110012E06Rik, 4930589M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 75906
Homologene: 11600
Cyp4f16
Name: cytochrome P450, family 4, subfamily f, polypeptide 16
Synonyms: 2310021J05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70101
Homologene: 135840
Vmn1r29
Name: vomeronasal 1 receptor 29
Synonyms: V1rc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 113859
Homologene: 123821
Cpne4
Name: copine IV
Synonyms: 4933406O10Rik, 3632411M23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74020
HGNC: HGNC:2317
Homologene: 26078
Ly9
Name: lymphocyte antigen 9
Synonyms: Lgp100, CD229, T100, SLAMF3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Lpcat2
Name: lysophosphatidylcholine acyltransferase 2
Synonyms: Aytl1, Aytl1a, LPCAT2, lysoPAFAT/LPCAT2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 270084
Homologene: 41201
Svs6
Name: seminal vesicle secretory protein 6
Synonyms: MSVSP99, Svp6, SVS VI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 20945
Homologene: 49347
Olfr564
Name: olfactory receptor 564
Synonyms: GA_x6K02T2PBJ9-5513635-5514627, MOR14-10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258356
Homologene: 121507
2700062C07Rik
Name: RIKEN cDNA 2700062C07 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 68046
VEGA: 18
Homologene: 12230
Pwwp4a
Name: PWWP domain containing 4A
Synonyms: Gm14685
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 574404
Homologene: 128534
Galnt2l
Name: polypeptide N-acetylgalactosaminyltransferase 2-like
Synonyms: Gm20388
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Igsf1
Name: immunoglobulin superfamily, member 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 209268
HGNC: HGNC:5948
Homologene: 1195
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 26,682,466 bp
  • A to G, chromosome 1 at 171,601,212 bp
  • T to A, chromosome 1 at 182,446,464 bp
  • A to G, chromosome 1 at 195,171,125 bp
  • T to C, chromosome 2 at 76,741,670 bp
  • G to A, chromosome 2 at 87,950,095 bp
  • T to C, chromosome 2 at 130,957,914 bp
  • T to A, chromosome 2 at 140,419,941 bp
  • T to C, chromosome 2 at 164,317,660 bp
  • T to C, chromosome 4 at 11,317,168 bp
  • A to T, chromosome 5 at 101,884,214 bp
  • T to A, chromosome 5 at 143,913,705 bp
  • A to G, chromosome 6 at 58,307,886 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to T, chromosome 7 at 96,550,051 bp
  • G to A, chromosome 7 at 102,803,850 bp
  • T to C, chromosome 8 at 63,143,989 bp
  • T to C, chromosome 8 at 92,879,417 bp
  • C to A, chromosome 8 at 109,621,708 bp
  • C to T, chromosome 8 at 120,172,052 bp
  • A to G, chromosome 9 at 3,035,804 bp
  • A to G, chromosome 9 at 7,464,298 bp
  • A to G, chromosome 9 at 62,428,947 bp
  • T to C, chromosome 9 at 104,900,285 bp
  • A to G, chromosome 10 at 28,475,280 bp
  • A to T, chromosome 10 at 53,675,208 bp
  • T to C, chromosome 10 at 62,296,094 bp
  • A to G, chromosome 10 at 94,045,372 bp
  • T to A, chromosome 10 at 127,191,289 bp
  • T to A, chromosome 11 at 57,189,788 bp
  • T to C, chromosome 11 at 73,185,246 bp
  • T to C, chromosome 11 at 101,295,126 bp
  • A to G, chromosome 11 at 114,785,809 bp
  • T to A, chromosome 12 at 52,519,514 bp
  • A to G, chromosome 13 at 73,685,869 bp
  • A to G, chromosome 13 at 99,229,296 bp
  • A to G, chromosome 13 at 100,645,082 bp
  • A to G, chromosome 13 at 110,399,489 bp
  • A to G, chromosome 14 at 34,396,239 bp
  • T to C, chromosome 14 at 57,438,301 bp
  • G to A, chromosome 14 at 57,472,979 bp
  • G to A, chromosome 16 at 73,978,448 bp
  • A to T, chromosome 17 at 32,542,999 bp
  • T to C, chromosome 17 at 37,805,363 bp
  • G to A, chromosome 18 at 12,181,623 bp
  • A to G, chromosome 18 at 24,477,276 bp
  • A to G, chromosome 18 at 47,306,431 bp
  • C to A, chromosome X at 49,782,936 bp
  • G to T, chromosome X at 73,127,655 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1422 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039478-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.