Strain Name:
C57BL/6J-MtgxR1423Btlr/Mmmh
Stock Number:
039479-MU
Citation ID:
RRID:MMRRC_039479-MU
Other Names:
R1423 (G1), C57BL/6J-MtgxR1423Btlr
Major Collection:

Gene Information

Mrtfb
Name: myocardin related transcription factor B
Synonyms: Gt4-1, MRTF-B, Mrtfb, Mkl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 239719
Homologene: 40917
Cyp11b2
Name: cytochrome P450, family 11, subfamily b, polypeptide 2
Synonyms: steroid-11-beta-hydroxylase, aldosterone synthase, Cyp11b-2, Cyp11b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 13072
Homologene: 128035
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117599
Homologene: 50463
Lima1
Name: LIM domain and actin binding 1
Synonyms: 3526402A12Rik, epithelial protein lost in neoplasm, EPLIN, 1110021C24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 65970
Homologene: 9484
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: 4932702D22Rik, Exdl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241624
Homologene: 17627
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Crtam
Name: cytotoxic and regulatory T cell molecule
Synonyms: class I-restricted T cell-associated molecule
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 54698
Homologene: 10454
Tpst2
Name: protein-tyrosine sulfotransferase 2
Synonyms: Tango13b, grt, D5Ucla3, grm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22022
Homologene: 2666
Itsn2
Name: intersectin 2
Synonyms: Eh domain, SH3 domain regulator of endocytosis 2, Sh3p18, Sh3d1B, Ese2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 20403
VEGA: 12
HGNC: HGNC:6184
Homologene: 22627
Lmbrd1
Name: LMBR1 domain containing 1
Synonyms: 0910001K20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68421
Homologene: 10156
Riok1
Name: RIO kinase 1
Synonyms: 3110046C13Rik, 5430416A05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 71340
VEGA: 13
Homologene: 6950
Nhlrc3
Name: NHL repeat containing 3
Synonyms: 8030451K01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 212114
Homologene: 35239
Edc4
Name: enhancer of mRNA decapping 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234699
Homologene: 40937
Armh4
Name: armadillo-like helical domain containing 4
Synonyms: 3632451O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 67419
Homologene: 12127
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: RdgB, DRES9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Bbs1
Name: Bardet-Biedl syndrome 1 (human)
Synonyms: D19Ertd609e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 52028
VEGA: 19
HGNC: HGNC:966
Homologene: 11641
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Plb1
Name: phospholipase B1
Synonyms: 4632413E21Rik, 4930539A06Rik, 4930433E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 665270
Homologene: 82108
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 211223
Homologene: 129606
Fbxo44
Name: F-box protein 44
Synonyms: Fbx6a, Fbxo6a, FBG3, FBX30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230903
Homologene: 13232
Gabrb2
Name: gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
Synonyms: C030021G16Rik, C030002O17Rik, Gabrb-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, Adgrc3, flamingo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Mertk
Name: MER proto-oncogene tyrosine kinase
Synonyms: Eyk, nmf12, Tyro 12, Nyk, Mer
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17289
HGNC: HGNC:7027
Homologene: 4626
Ttbk1
Name: tau tubulin kinase 1
Synonyms: C330008L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 106763
VEGA: 17
Homologene: 50342
Vmn2r121
Name: vomeronasal 2, receptor 121
Synonyms: EG625699
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 100038941
Homologene: 129606
Pcdhb15
Name: protocadherin beta 15
Synonyms: Pcdhb7, PcdhbO
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Parp14
Name: poly (ADP-ribose) polymerase family, member 14
Synonyms: collaborator of Stat6, CoaSt6, 1600029O10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 547253
Homologene: 19697
Isca1
Name: iron-sulfur cluster assembly 1
Synonyms: Hbld2, 1810010A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 69046
Homologene: 87862
Bag4
Name: BCL2-associated athanogene 4
Synonyms: 2410112I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67384
HGNC: HGNC:940
Homologene: 31270
Tigit
Name: T cell immunoreceptor with Ig and ITIM domains
Synonyms: Vstm3, ENSMUSG00000071552
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 100043314
VEGA: 16
Homologene: 18358
Olfr654
Name: olfactory receptor 654
Synonyms: GA_x6K02T2PBJ9-7215221-7216195, MOR38-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258377
Homologene: 90859
Ankrd13d
Name: ankyrin repeat domain 13 family, member D
Synonyms: 0710001P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68423
Homologene: 27612
Poc1b
Name: POC1 centriolar protein B
Synonyms: Wdr51b, 4933430F16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 382406
Homologene: 41728
Hesx1
Name: homeobox gene expressed in ES cells
Synonyms: Rpx, HES-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 15209
HGNC: HGNC:4877
Homologene: 20831
Vmn1r3
Name: vomeronasal 1 receptor 3
Synonyms: Gm11778
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100312471
Homologene: 128342
Fbxo16
Name: F-box protein 16
Synonyms: Fbx16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50759
VEGA: 14
Homologene: 9273
Prl7b1
Name: prolactin family 7, subfamily b, member 1
Synonyms: 1600014J19Rik, Prlpn, PLP-N
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 75596
Homologene: 17809
Btbd7
Name: BTB (POZ) domain containing 7
Synonyms: 5730507E09Rik, E130118E17Rik, FUP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238386
VEGA: 12
Homologene: 34300
Bmyc
Name: brain expressed myelocytomatosis oncogene
Synonyms: 2900002K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 107771
Homologene: 11343
Olfr1134
Name: olfactory receptor 1134
Synonyms: MOR176-1, GA_x6K02T2Q125-49162076-49161138
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 259032
Homologene: 37013
Mrps28
Name: mitochondrial ribosomal protein S28
Synonyms: 1500012D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 66230
Homologene: 8519
Olfr678
Name: olfactory receptor 678
Synonyms: GA_x6K02T2PBJ9-7698491-7699432, MOR32-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 258753
Homologene: 27254
Olfr285
Name: olfactory receptor 285
Synonyms: GA_x6K02T2NBG7-5440777-5441736, MOR160-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 257943
Homologene: 66175
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 24,746,878 bp
  • A to G, chromosome 2 at 25,707,224 bp
  • A to T, chromosome 2 at 87,656,330 bp
  • A to T, chromosome 2 at 119,540,013 bp
  • T to C, chromosome 2 at 128,778,963 bp
  • T to G, chromosome 2 at 180,195,641 bp
  • T to C, chromosome 3 at 8,900,124 bp
  • A to T, chromosome 3 at 53,462,415 bp
  • A to T, chromosome 4 at 3,185,231 bp
  • C to G, chromosome 4 at 148,156,269 bp
  • A to G, chromosome 5 at 32,293,257 bp
  • T to C, chromosome 5 at 109,293,227 bp
  • T to A, chromosome 5 at 112,307,622 bp
  • C to T, chromosome 7 at 104,588,475 bp
  • T to G, chromosome 7 at 105,070,019 bp
  • T to C, chromosome 8 at 25,768,274 bp
  • C to T, chromosome 8 at 105,891,211 bp
  • C to A, chromosome 9 at 40,973,622 bp
  • A to T, chromosome 9 at 108,826,905 bp
  • T to C, chromosome 10 at 99,152,863 bp
  • T to A, chromosome 10 at 120,108,966 bp
  • A to G, chromosome 11 at 42,529,471 bp
  • T to C, chromosome 12 at 4,673,572 bp
  • T to C, chromosome 12 at 102,785,475 bp
  • T to A, chromosome 13 at 27,602,127 bp
  • T to C, chromosome 13 at 38,049,114 bp
  • G to T, chromosome 13 at 48,885,743 bp
  • T to C, chromosome 13 at 59,762,779 bp
  • TCCC to TCC, chromosome 13 at 100,154,847 bp
  • G to A, chromosome 13 at 100,154,872 bp
  • G to A, chromosome 13 at 100,154,878 bp
  • C to T, chromosome 13 at 100,161,860 bp
  • A to T, chromosome 14 at 27,001,919 bp
  • T to C, chromosome 14 at 49,751,439 bp
  • T to C, chromosome 14 at 65,287,174 bp
  • C to A, chromosome 15 at 74,853,130 bp
  • T to C, chromosome 15 at 98,313,443 bp
  • T to A, chromosome 15 at 99,819,745 bp
  • T to C, chromosome 16 at 13,412,241 bp
  • G to A, chromosome 16 at 35,856,760 bp
  • T to C, chromosome 16 at 43,649,032 bp
  • T to C, chromosome 17 at 46,446,154 bp
  • A to T, chromosome 18 at 37,473,922 bp
  • G to A, chromosome 19 at 4,112,392 bp
  • A to G, chromosome 19 at 4,281,069 bp
  • G to A, chromosome 19 at 4,894,263 bp
  • T to A, chromosome X at 124,129,905 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1423 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039479-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.