Strain Name:
C57BL/6J-MtgxR1426Btlr/Mmmh
Stock Number:
039482-MU
Citation ID:
RRID:MMRRC_039482-MU
Other Names:
R1426 (G1), C57BL/6J-MtgxR1426Btlr
Major Collection:

Gene Information

Prkar2b
Name: protein kinase, cAMP dependent regulatory, type II beta
Synonyms: Pkarb2, PKARIIbeta, RII(beta)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 19088
HGNC: HGNC:9392
Homologene: 37666
Tert
Name: telomerase reverse transcriptase
Synonyms: TR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 21752
VEGA: 13
Homologene: 31141
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: m4mbt, 4732493N06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 214669
Homologene: 12882
Brd2
Name: bromodomain containing 2
Synonyms: Ring3, D17H6S113E, Frg-1, Rnf3, Fsrg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 14312
HGNC: HGNC:1103
Homologene: 74540
Rbck1
Name: RanBP-type and C3HC4-type zinc finger containing 1
Synonyms: HOIL-1L, Ubce7ip3, HOIL-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 24105
Homologene: 32448
Brat1
Name: BRCA1-associated ATM activator 1
Synonyms: Baat1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231841
Homologene: 16776
Lss
Name: lanosterol synthase
Synonyms: Osc, 2810025N20Rik, D10Ertd116e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 16987
HGNC: HGNC:6708
Homologene: 37408
Traf7
Name: TNF receptor-associated factor 7
Synonyms: RFWD1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224619
Homologene: 12998
Cyp4x1
Name: cytochrome P450, family 4, subfamily x, polypeptide 1
Synonyms: Cyp4a28-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 81906
Homologene: 75853
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: eIF2alpha, Eif2a, 0910001O23Rik, 2410026C18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Arhgap28
Name: Rho GTPase activating protein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 268970
Homologene: 18264
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: SRC-a/NCoA-1, SRC1, steroid receptor coactivator-1, bHLHe74, SRC-1, KAT13A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230119
Homologene: 8913
Lama3
Name: laminin, alpha 3
Synonyms: nicein, 150kDa, [a]3B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 16774
HGNC: HGNC:6483
Homologene: 18279
Myh11
Name: myosin, heavy polypeptide 11, smooth muscle
Synonyms: smMHC, SM2, SM1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 17880
VEGA: 16
HGNC: HGNC:7569
Homologene: 128512
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip2, Birc1b, Naip-rs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Xpc
Name: xeroderma pigmentosum, complementation group C
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22591
Homologene: 3401
Vmn1r194
Name: vomeronasal 1 receptor 194
Synonyms: Gm11294
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 626299
Homologene: 110880
Slc7a4
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 224022
Homologene: 20883
Slc25a48
Name: solute carrier family 25, member 48
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 328258
Homologene: 27065
Pnmal1
Name: PNMA-like 1
Synonyms: 4930488B01Rik, 0710005I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 71691
Homologene: 10073
Gsto1
Name: glutathione S-transferase omega 1
Synonyms: p28, GSTX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 14873
Homologene: 37971
Zkscan7
Name: zinc finger with KRAB and SCAN domains 7
Synonyms: Zfp167
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 382118
VEGA: 9
Homologene: 83284
Zyg11b
Name: zyg-ll family member B, cell cycle regulator
Synonyms: 1110046I03Rik, 2810482G21Rik, D4Mgi23, LOC242610
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 414872
Homologene: 14600
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, wl, Ib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50769
Homologene: 4443
Olfr262
Name: olfactory receptor 262
Synonyms: GA_x6K02T2N4A9-18144-19082, MOR214-9, MOR214-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258683
Abcc10
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 10
Synonyms: Mrp7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 224814
HGNC: HGNC:52
Homologene: 58616
Lrrc34
Name: leucine rich repeat containing 34
Synonyms: 1700007J06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 71827
Homologene: 27419
Dip2a
Name: disco interacting protein 2 homolog A
Synonyms: 4931420H10Rik, Dip2, Kiaa0184-hp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64451
Homologene: 41012
Lrrc45
Name: leucine rich repeat containing 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217366
Homologene: 17019
Adh1
Name: alcohol dehydrogenase 1 (class I)
Synonyms: Adh1tl, class I alcohol dehydrogenase, Adh-1-t, Adh1-e, Adh-1, Adh-1t, Adh-1e, ADH-AA, Adh1-t
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 11522
Homologene: 73888
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: Gm29096, Gm6976, 5033413D22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 75973
Homologene: 136355
Hspa14
Name: heat shock protein 14
Synonyms: NST-1, Hsp70-4, HSP70L1, 70kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 50497
Homologene: 74307
Pafah1b3
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
Synonyms: mus[g], Pafahg
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 18476
HGNC: HGNC:8576
Homologene: 1933
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 330301
Homologene: 51849
Elovl7
Name: ELOVL family member 7, elongation of long chain fatty acids (yeast)
Synonyms: 9130013K24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 74559
VEGA: 13
Homologene: 23672
Olfr768
Name: olfactory receptor 768
Synonyms: MOR114-4, GA_x6K02T2PULF-10779441-10778503
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 258863
Homologene: 17159
Rcor2
Name: REST corepressor 2
Synonyms: 1A13, CoREST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 104383
Homologene: 14280
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 3,508,821 bp
  • A to T, chromosome 2 at 152,327,241 bp
  • T to A, chromosome 3 at 30,643,579 bp
  • A to G, chromosome 3 at 138,286,795 bp
  • T to C, chromosome 4 at 44,993,968 bp
  • G to A, chromosome 4 at 108,250,812 bp
  • T to A, chromosome 4 at 115,112,791 bp
  • G to A, chromosome 5 at 140,718,013 bp
  • A to G, chromosome 6 at 47,825,079 bp
  • A to G, chromosome 6 at 91,493,238 bp
  • C to T, chromosome 7 at 16,960,984 bp
  • T to C, chromosome 7 at 25,297,135 bp
  • T to C, chromosome 9 at 122,895,163 bp
  • T to C, chromosome 10 at 41,553,182 bp
  • T to C, chromosome 10 at 76,279,820 bp
  • T to C, chromosome 10 at 76,536,303 bp
  • A to T, chromosome 10 at 129,093,690 bp
  • A to T, chromosome 11 at 120,720,013 bp
  • T to A, chromosome 12 at 4,270,737 bp
  • A to T, chromosome 12 at 31,962,988 bp
  • A to G, chromosome 12 at 78,881,168 bp
  • T to A, chromosome 13 at 22,245,066 bp
  • T to A, chromosome 13 at 56,448,991 bp
  • T to C, chromosome 13 at 73,642,353 bp
  • T to C, chromosome 13 at 100,161,854 bp
  • C to T, chromosome 13 at 100,161,860 bp
  • T to A, chromosome 13 at 108,282,494 bp
  • T to C, chromosome 14 at 59,860,270 bp
  • T to A, chromosome 15 at 81,676,317 bp
  • T to A, chromosome 16 at 14,205,931 bp
  • A to G, chromosome 16 at 17,573,944 bp
  • A to T, chromosome 17 at 24,511,681 bp
  • ATCTTCTTC to ATCTTC, chromosome 17 at 34,114,007 bp
  • A to T, chromosome 17 at 46,324,435 bp
  • C to A, chromosome 17 at 67,857,464 bp
  • G to T, chromosome 18 at 12,481,098 bp
  • A to G, chromosome 19 at 7,271,030 bp
  • G to T, chromosome 19 at 12,241,182 bp
  • A to G, chromosome 19 at 47,857,942 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1426 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039482-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.