Strain Name:
C57BL/6J-MtgxR1441Btlr/Mmmh
Stock Number:
039496-MU
Citation ID:
RRID:MMRRC_039496-MU
Other Names:
R1441 (G1), C57BL/6J-MtgxR1441Btlr
Major Collection:

Gene Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 22288
VEGA: 10
Homologene: 21398
Itk
Name: IL2 inducible T cell kinase
Synonyms: Tcsk, Emt, Tsk
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 16428
HGNC: HGNC:6171
Homologene: 4051
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Fbxl10, Jhdm1b, Cxxc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 30841
Homologene: 13069
Rufy3
Name: RUN and FYVE domain containing 3
Synonyms: Rpipx, 6330416M07Rik, D5Bwg0860e, 2810428M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 52822
Homologene: 87809
Pabpc4
Name: poly(A) binding protein, cytoplasmic 4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 230721
HGNC: HGNC:8557
Homologene: 37855
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: Wdr9, D530019K20Rik, 5330419I02Rik, G1-403-16, repro5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 93871
Homologene: 23130
Tasor
Name: transcription activation suppressor
Synonyms: D14Abb1e, 4933409E02Rik, MommeD6, Fam208a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218850
VEGA: 14
Homologene: 9062
Sf3a3
Name: splicing factor 3a, subunit 3
Synonyms: 4930512K19Rik, 60kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 75062
Homologene: 4949
Prpf8
Name: pre-mRNA processing factor 8
Synonyms: Sfprp8l, Prp8, DBF3/PRP8, D11Bwg0410e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192159
Homologene: 4706
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Impdh2
Name: inosine monophosphate dehydrogenase 2
Synonyms: IMP dehydrogenase type II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 23918
HGNC: HGNC:6053
Homologene: 48919
Ror1
Name: receptor tyrosine kinase-like orphan receptor 1
Synonyms: Ntrkr1, 2810404D04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 26563
Homologene: 3675
Rasa1
Name: RAS p21 protein activator 1
Synonyms: Gap, p120-rasGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 218397
HGNC: HGNC:9871
Homologene: 2168
Pip4p2
Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2
Synonyms: Tmem55a, 2610319K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 72519
Homologene: 23117
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 74111
Homologene: 7158
Phactr4
Name: phosphatase and actin regulator 4
Synonyms: C330013F19Rik, 3110001B12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 100169
Homologene: 41537
Tpcn2
Name: two pore segment channel 2
Synonyms: D830047E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233979
Homologene: 16375
Ttn
Name: titin
Synonyms: shru, connectin, mdm, 2310057K23Rik, D330041I19Rik, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, L56, 2310074I15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 22138
Homologene: 130650
Trim17
Name: tripartite motif-containing 17
Synonyms: Rnf16, terf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 56631
Homologene: 9387
Txndc11
Name: thioredoxin domain containing 11
Synonyms: Txdc11, 2810408E11Rik, EFP1, EF-hand binding protein 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 106200
Homologene: 9301
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Birc1e, Naip-rs3, Lgn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Dhx36
Name: DEAH (Asp-Glu-Ala-His) box polypeptide 36
Synonyms: Ddx36, 2810407E23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 72162
Homologene: 6356
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: erythroid, Spna1, Spna-1, ihj
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 20739
Homologene: 74460
G6pc2
Name: glucose-6-phosphatase, catalytic, 2
Synonyms: islet specific glucose-6-phosphatase, G6pc-rs, IGRP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 14378
Homologene: 41423
Olfr1301
Name: olfactory receptor 1301
Synonyms: MOR248-5, GA_x6K02T2Q125-72805651-72806589
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 258889
Homologene: 74057
Espn
Name: espin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 56226
Homologene: 23164
Ccser1
Name: coiled-coil serine rich 1
Synonyms: Fam190a, 6230405M12Rik, C130092O11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 232035
Homologene: 28086
Mink1
Name: misshapen-like kinase 1 (zebrafish)
Synonyms: Ysk2, Map4k6, MINK, Misshapen/NIKs-related kinase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 50932
Homologene: 56762
Mroh2a
Name: maestro heat-like repeat family member 2A
Synonyms: ENSMUSG00000044873, Heatr7b1, OTTMUSG00000020804
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 100040766
Homologene: 85300
Mmp12
Name: matrix metallopeptidase 12
Synonyms: Mmel, MMP12, macrophage elastase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 17381
HGNC: HGNC:7158
Homologene: 20547
Megf8
Name: multiple EGF-like-domains 8
Synonyms: Egfl4, b2b1702Clo, m687Ddg, b2b288Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Olfr358
Name: olfactory receptor 358
Synonyms: MOR159-4, GA_x6K02T2NLDC-33697309-33696317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 227789
Homologene: 74157
Myo1a
Name: myosin IA
Synonyms: BBM-I, Myhl, brush border myosin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 432516
VEGA: 10
HGNC: HGNC:7595
Homologene: 21113
Fam149a
Name: family with sequence similarity 149, member A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 212326
Homologene: 27540
Ccdc13
Name: coiled-coil domain containing 13
Synonyms: 2900041A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 100502861
Homologene: 87213
Nlrp4d
Name: NLR family, pyrin domain containing 4D
Synonyms: Nalp-beta, Nalp4d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 384752
Ninl
Name: ninein-like
Synonyms: LOC381388, LOC381387, 4930519N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 78177
Homologene: 57024
Adamts18
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
Synonyms: E130314N14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 208936
Homologene: 65241
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 628422
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4930549K11Rik, 4932423M01Rik, 4930554C01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75338
Homologene: 32709
Tm9sf1
Name: transmembrane 9 superfamily member 1
Synonyms: 1200014D02Rik, MP70
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 74140
Homologene: 4671
Olfr202
Name: olfactory receptor 202
Synonyms: GA_x54KRFPKG5P-55498766-55497843, MOR182-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 258997
Homologene: 138323
Arsk
Name: arylsulfatase K
Synonyms: 2810429K17Rik, 4833414G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 77041
Homologene: 12670
Ankrd16
Name: ankyrin repeat domain 16
Synonyms: D430029B21Rik, 2810455F06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 320816
Homologene: 19509
Rbks
Name: ribokinase
Synonyms: 5230400M11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 71336
Homologene: 5482
Olfr893
Name: olfactory receptor 893
Synonyms: MOR170-11, GA_x6K02T2PVTD-31889215-31890153
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 258333
Homologene: 133626
Olfr441
Name: olfactory receptor 441
Synonyms: MOR261-3, GA_x6K02T2P3E9-4442577-4441645
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 258649
Homologene: 88438
Cd44
Name: CD44 antigen
Synonyms: Pgp-1, Ly-24, HERMES
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 12505
HGNC: HGNC:1681
Homologene: 508
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: Ptpn8, 70zpep
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Ephb4
Name: Eph receptor B4
Synonyms: Tyro11, Htk, Myk1, b2b2412Clo, MDK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 13846
HGNC: HGNC:3395
Homologene: 20939
Rpusd4
Name: RNA pseudouridylate synthase domain containing 4
Synonyms: 2410001E19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 71989
Homologene: 32794
Eepd1
Name: endonuclease/exonuclease/phosphatase family domain containing 1
Synonyms: 2310005P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 67484
Homologene: 12144
Olfr235
Name: olfactory receptor 235
Synonyms: GA_x6K02T057QT-4025-4642, GA_x6K02T03CT6-1-477, Olfr245, GA_x6K02T2LL2P-1028-792, MOR214-3, Olfr232, MOR214-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 258681
Card9
Name: caspase recruitment domain family, member 9
Synonyms: LOC332579
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 332579
Homologene: 14150
Slc7a12
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 12
Synonyms: asc-type amino acid transporter 2, XAT1, Asc-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 140918
Homologene: 76812
Gcsam
Name: germinal center associated, signaling and motility
Synonyms: M17, Gcet2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 14525
Homologene: 49157
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 88,241,631 bp
  • A to G, chromosome 1 at 174,215,466 bp
  • T to C, chromosome 2 at 11,778,746 bp
  • T to C, chromosome 2 at 26,359,390 bp
  • C to A, chromosome 2 at 37,005,119 bp
  • G to A, chromosome 2 at 69,220,854 bp
  • T to A, chromosome 2 at 76,741,777 bp
  • T to A, chromosome 2 at 102,846,418 bp
  • T to C, chromosome 2 at 111,755,002 bp
  • C to A, chromosome 2 at 150,971,124 bp
  • T to G, chromosome 3 at 14,497,354 bp
  • T to A, chromosome 3 at 62,472,132 bp
  • G to T, chromosome 3 at 103,874,247 bp
  • A to T, chromosome 4 at 14,892,477 bp
  • A to G, chromosome 4 at 100,440,983 bp
  • G to A, chromosome 4 at 123,286,665 bp
  • T to C, chromosome 4 at 124,725,142 bp
  • G to A, chromosome 4 at 132,377,248 bp
  • G to T, chromosome 4 at 152,138,419 bp
  • C to T, chromosome 5 at 31,659,997 bp
  • T to C, chromosome 5 at 88,632,515 bp
  • T to C, chromosome 5 at 120,131,176 bp
  • C to T, chromosome 5 at 122,932,880 bp
  • C to T, chromosome 5 at 137,361,247 bp
  • T to C, chromosome 6 at 43,115,946 bp
  • C to T, chromosome 6 at 62,380,032 bp
  • G to A, chromosome 7 at 10,358,960 bp
  • T to C, chromosome 7 at 25,342,438 bp
  • G to A, chromosome 7 at 41,837,440 bp
  • T to A, chromosome 7 at 90,244,143 bp
  • G to A, chromosome 7 at 145,260,134 bp
  • G to T, chromosome 8 at 45,355,647 bp
  • A to T, chromosome 8 at 113,754,562 bp
  • C to T, chromosome 9 at 7,354,787 bp
  • G to A, chromosome 9 at 25,483,203 bp
  • C to A, chromosome 9 at 35,272,769 bp
  • T to C, chromosome 9 at 38,209,481 bp
  • C to A, chromosome 9 at 108,564,776 bp
  • A to T, chromosome 9 at 121,813,449 bp
  • A to G, chromosome 10 at 12,683,295 bp
  • A to C, chromosome 10 at 28,551,766 bp
  • T to C, chromosome 10 at 76,471,166 bp
  • C to T, chromosome 10 at 127,719,279 bp
  • T to C, chromosome 11 at 46,336,346 bp
  • A to G, chromosome 11 at 58,965,192 bp
  • T to A, chromosome 11 at 70,607,114 bp
  • A to G, chromosome 11 at 75,508,972 bp
  • A to T, chromosome 13 at 76,074,964 bp
  • C to T, chromosome 13 at 85,252,421 bp
  • T to C, chromosome 13 at 100,219,717 bp
  • T to A, chromosome 14 at 27,464,260 bp
  • T to C, chromosome 14 at 55,636,325 bp
  • C to A, chromosome 16 at 11,134,550 bp
  • T to A, chromosome 16 at 45,613,038 bp
  • G to A, chromosome 16 at 59,283,865 bp
  • A to C, chromosome 16 at 96,066,151 bp
  • T to A, chromosome 19 at 12,268,386 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1441 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039496-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.