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Strain Name:
C57BL/6J-MtgxR1450Btlr/Mmmh
Stock Number:
039505-MU
Citation ID:
RRID:MMRRC_039505-MU
Other Names:
R1450 (G1), C57BL/6J-MtgxR1450Btlr
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mcmbp
Name: minichromosome maintenance complex binding protein
Synonyms: 1110007A13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210711
Homologene: 11749
Kpna2
Name: karyopherin subunit alpha 2
Synonyms: pendulin, m-importin, m-importin-alpha-P1, Rch1, 2410044B12Rik, Importin alpha, importin alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16647
HGNC: HGNC:6395
Homologene: 1708
Ints3
Name: integrator complex subunit 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229543
Homologene: 11309
Ipo5
Name: importin 5
Synonyms: RanBP5, 5730478E03Rik, 1110011C18Rik, Kpnb3, IMB3, importin beta 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70572
VEGA: 14
HGNC: HGNC:6402
Homologene: 1710
Clock
Name: clock circadian regulator
Synonyms: 5330400M04Rik, KAT13D, bHLHe8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668303
Homologene: 18970
Igfbp5
Name: insulin-like growth factor binding protein 5
Synonyms: IGFBP-5, IGFBP-5P
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16011
HGNC: HGNC:5474
Homologene: 56489
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: mAspAT, mitochondrial aspartate aminotransferase, FABP-pm, plasma membrane fatty acid binding protein, Kyat4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Dgcr2
Name: DiGeorge syndrome critical region gene 2
Synonyms: Dgcr2, Idd, Lan, Sez12, DGS-C, Dgsc, 9930034O06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13356
HGNC: HGNC:2845
Homologene: 31292
Aarsd1
Name: alanyl-tRNA synthetase domain containing 1
Synonyms: 2310044P18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69684
Homologene: 6821
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Mtr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase
Synonyms: methionine synthase, MS, D830038K18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238505
VEGA: 13
HGNC: HGNC:7468
Homologene: 37280
Maea
Name: macrophage erythroblast attacher
Synonyms: 1110030D19Rik, Gid9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59003
Homologene: 4298
Pnisr
Name: PNN interacting serine/arginine-rich
Synonyms: 5730406M06Rik, Sfrs18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66625
Homologene: 32802
Zdhhc5
Name: zinc finger, DHHC domain containing 5
Synonyms: Zisp, 1110032A17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228136
Homologene: 9147
Raver2
Name: ribonucleoprotein, PTB-binding 2
Synonyms: A430091O22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242570
Homologene: 18829
Tars3
Name: threonyl-tRNA synthetase 3
Synonyms: A530046H20Rik, Tarsl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272396
Homologene: 65036
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Lct
Name: lactase
Synonyms: LOC226413, Lphl, LPH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226413
HGNC: HGNC:6530
Homologene: 124204
Amfr
Name: autocrine motility factor receptor
Synonyms: gp78
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23802
HGNC: HGNC:463
Homologene: 888
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Cubn
Name: cubilin
Synonyms: D2Wsu88e, intrinsic factor-cobalamin receptor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 65969
HGNC: HGNC:2548
Homologene: 37434
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Tas2r124
Name: taste receptor, type 2, member 124
Synonyms: Tas2r24, mGR24, mt2r50, T2R24
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387351
Homologene: 87293
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Marco
Name: macrophage receptor with collagenous structure
Synonyms: Scara2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17167
HGNC: HGNC:6895
Homologene: 4928
Dennd4a
Name: DENN domain containing 4A
Synonyms: F730015K02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102442
VEGA: 9
Homologene: 55933
Cngb3
Name: cyclic nucleotide gated channel beta 3
Synonyms: CNG6, CCNC2, Cngbeta2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30952
HGNC: HGNC:2153
Homologene: 40908
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin, B230334C09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Ankrd69
Name: ankyrin repeat domain 69
Synonyms: 4930456F22Rik, 4921537P18Rik, Poteg
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70952
Homologene: 134158
Hs2st1
Name: heparan sulfate 2-O-sulfotransferase 1
Synonyms: Hs2st
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23908
HGNC: HGNC:5193
Homologene: 8025
Peg12
Name: paternally expressed 12
Synonyms: Frat3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27412
HGNC: HGNC:3944
Stac3
Name: SH3 and cysteine rich domain 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237611
Homologene: 17039
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Rp1l1
Name: retinitis pigmentosa 1 homolog like 1
Synonyms: Dcdc4, Rp1hl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 271209
VEGA: 14
Homologene: 105870
Or51ac3
Name: olfactory receptor family 51 subfamily AC member 3
Synonyms: GA_x6K02T2PBJ9-6289676-6288723, MOR19-1, Olfr616
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259103
Homologene: 64957
Sox30
Name: SRY (sex determining region Y)-box 30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214105
Homologene: 34027
Nlrp10
Name: NLR family, pyrin domain containing 10
Synonyms: 6430548I20Rik, Pynod, Nalp10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244202
Homologene: 18468
Ubtfl1
Name: upstream binding transcription factor, RNA polymerase I-like 1
Synonyms: B020006M18Rik, Hmgpi
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 546118
Homologene: 110115
Tmem143
Name: transmembrane protein 143
Synonyms: 2310076O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70209
Homologene: 10105
Bag6
Name: BCL2-associated athanogene 6
Synonyms: D17H6S52E, G3, 2410045D21Rik, Scythe, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
Or10ak7
Name: olfactory receptor family 10 subfamily AK member 7
Synonyms: MOR259-1, GA_x6K02T2QD9B-18602750-18603691, MOR259-13, MOR259-1, Olfr1519, Olfr1328
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258394
Homologene: 121524
Rgr
Name: retinal G protein coupled receptor
Synonyms: RGR opsin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57811
VEGA: 14
HGNC: HGNC:9990
Homologene: 37709
Or5e1
Name: olfactory receptor family 5 subfamily E member 1
Synonyms: GA_x6K02T2PBJ9-11084889-11085818, MOR195-1, Olfr513
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258718
Homologene: 64908
Prss40
Name: serine protease 40
Synonyms: Tesp2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21756
Homologene: 69043
Adh4
Name: alcohol dehydrogenase 4 (class II), pi polypeptide
Synonyms: mouse class II type ADH, Adh2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26876
HGNC: HGNC:252
Homologene: 20162
Pigc
Name: phosphatidylinositol glycan anchor biosynthesis, class C
Synonyms: 3110030E07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67292
HGNC: HGNC:8960
Homologene: 7109
Dimt1
Name: DIM1 rRNA methyltransferase and ribosome maturation factor
Synonyms: 1500031M22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66254
VEGA: 13
Homologene: 7047
Ccdc185
Name: coiled-coil domain containing 185
Synonyms: 4922505E12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 433386
Homologene: 17631
Mtcl3
Name: MTCL family member 3
Synonyms: 6330407J23Rik, Soga3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67412
VEGA: 10
Homologene: 28227
Sesn3
Name: sestrin 3
Synonyms: SEST3, 5630400E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75747
Homologene: 14386
Lonrf2
Name: LON peptidase N-terminal domain and ring finger 2
Synonyms: 2900060P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381338
Homologene: 18871
Fem1a
Name: fem 1 homolog a
Synonyms: Eprap
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14154
VEGA: 17
Homologene: 7713
Ly6g
Name: lymphocyte antigen 6 family member G
Synonyms: Gr1, Ly-6G, Gr-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 546644
Homologene: 113718
Zfp40
Name: zinc finger protein 40
Synonyms: NTfin12, Zfp-40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22700
Homologene: 136312
Tm4sf19
Name: transmembrane 4 L six family member 19
Synonyms: EG277203
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 277203
Homologene: 64632
Cfap276
Name: cilia and flagella associated protein 276
Synonyms: 1700013F07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75504
Homologene: 18986
Hcar2
Name: hydroxycarboxylic acid receptor 2
Synonyms: PUMA-G, HM74, Pumag, Gpr109b, Gpr109a, Niacr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80885
Homologene: 4391
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,188,395 bp
  • T to A, chromosome 1 at 34,212,259 bp
  • T to A, chromosome 1 at 34,556,097 bp
  • G to A, chromosome 1 at 38,813,276 bp
  • T to A, chromosome 1 at 72,873,889 bp
  • A to T, chromosome 1 at 120,476,745 bp
  • A to G, chromosome 1 at 128,307,903 bp
  • A to G, chromosome 1 at 150,652,506 bp
  • A to G, chromosome 1 at 161,971,253 bp
  • T to G, chromosome 1 at 182,747,564 bp
  • A to G, chromosome 2 at 13,360,319 bp
  • A to G, chromosome 2 at 84,702,389 bp
  • T to C, chromosome 2 at 156,511,825 bp
  • C to A, chromosome 3 at 90,432,828 bp
  • T to A, chromosome 3 at 108,542,483 bp
  • T to C, chromosome 3 at 126,957,302 bp
  • C to T, chromosome 3 at 138,424,174 bp
  • C to T, chromosome 3 at 144,434,718 bp
  • T to G, chromosome 3 at 158,187,044 bp
  • A to T, chromosome 4 at 19,395,922 bp
  • G to T, chromosome 4 at 21,874,912 bp
  • T to C, chromosome 4 at 101,136,152 bp
  • A to T, chromosome 4 at 102,601,635 bp
  • T to C, chromosome 4 at 118,934,510 bp
  • T to C, chromosome 4 at 139,468,028 bp
  • T to C, chromosome 5 at 33,365,800 bp
  • G to A, chromosome 5 at 76,262,731 bp
  • A to G, chromosome 5 at 106,918,458 bp
  • A to T, chromosome 5 at 123,864,750 bp
  • C to G, chromosome 6 at 52,260,647 bp
  • G to C, chromosome 6 at 52,260,648 bp
  • A to T, chromosome 6 at 58,876,515 bp
  • A to G, chromosome 6 at 132,755,056 bp
  • T to G, chromosome 7 at 45,907,108 bp
  • C to A, chromosome 7 at 62,463,576 bp
  • A to T, chromosome 7 at 65,647,496 bp
  • A to G, chromosome 7 at 103,564,451 bp
  • A to T, chromosome 7 at 108,755,512 bp
  • A to G, chromosome 7 at 108,925,388 bp
  • G to T, chromosome 7 at 128,715,931 bp
  • T to G, chromosome 8 at 15,945,180 bp
  • T to C, chromosome 8 at 27,447,843 bp
  • T to C, chromosome 8 at 93,987,747 bp
  • C to T, chromosome 8 at 95,871,986 bp
  • T to A, chromosome 9 at 14,316,224 bp
  • A to G, chromosome 9 at 18,409,913 bp
  • A to G, chromosome 9 at 64,911,665 bp
  • G to A, chromosome 9 at 110,633,672 bp
  • A to T, chromosome 10 at 29,147,740 bp
  • T to C, chromosome 10 at 127,504,885 bp
  • A to T, chromosome 11 at 9,430,531 bp
  • C to A, chromosome 11 at 46,017,271 bp
  • T to A, chromosome 11 at 60,495,482 bp
  • T to C, chromosome 11 at 65,927,786 bp
  • T to A, chromosome 11 at 101,421,905 bp
  • A to G, chromosome 11 at 106,997,309 bp
  • C to T, chromosome 12 at 112,173,852 bp
  • T to A, chromosome 13 at 12,193,733 bp
  • A to G, chromosome 13 at 106,947,643 bp
  • A to T, chromosome 14 at 37,044,684 bp
  • T to A, chromosome 14 at 64,028,150 bp
  • T to C, chromosome 14 at 120,944,393 bp
  • A to G, chromosome 15 at 75,158,633 bp
  • T to C, chromosome 16 at 17,856,814 bp
  • A to T, chromosome 16 at 32,407,963 bp
  • C to A, chromosome 17 at 6,027,324 bp
  • A to T, chromosome 17 at 23,175,258 bp
  • T to A, chromosome 17 at 35,141,958 bp
  • T to C, chromosome 17 at 56,257,579 bp
  • T to A, chromosome 18 at 20,409,184 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1450 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039505-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.