Strain Name:
C57BL/6J-MtgxR1454Btlr/Mmmh
Stock Number:
039509-MU
Citation ID:
RRID:MMRRC_039509-MU
Other Names:
R1454 (G1), C57BL/6J-MtgxR1454Btlr
Major Collection:

Gene Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 52615
Homologene: 32256
Adcy10
Name: adenylate cyclase 10
Synonyms: 4930431D04Rik, soluble adenylyl cyclase, Sacy, sAC
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 271639
Homologene: 10188
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Dock1
Name: dedicator of cytokinesis 1
Synonyms: b2b3190Clo, 9130006G06Rik, Dock180, D630004B07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Agap1
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Synonyms: Centg2, Ggap1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 347722
Homologene: 56689
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: 2310057J16Rik, Nezha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69697
Homologene: 18966
Csnk2a1
Name: casein kinase 2, alpha 1 polypeptide
Synonyms: Csnk2a1-rs4, CK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12995
HGNC: HGNC:2457
Homologene: 90874
Cenpc1
Name: centromere protein C1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 12617
HGNC: HGNC:1854
Homologene: 1371
Dctn1
Name: dynactin 1
Synonyms: p150glued, p150, Glued
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 13191
HGNC: HGNC:2711
Homologene: 3011
Trappc9
Name: trafficking protein particle complex 9
Synonyms: Nibp, 1810044A24Rik, 4632408O18Rik, 2900005P22Rik, TRS130
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 76510
VEGA: 15
Homologene: 81931
Hip1
Name: huntingtin interacting protein 1
Synonyms: HIP-1, 2610109B09Rik, E130315I21Rik, A930014B11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 215114
HGNC: HGNC:4913
Homologene: 68463
Thbs1
Name: thrombospondin 1
Synonyms: TSP1, tbsp1, Thbs-1, TSP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 21825
Homologene: 31142
Zp3
Name: zona pellucida glycoprotein 3
Synonyms: Zp-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22788
Homologene: 5178
Msh6
Name: mutS homolog 6
Synonyms: Msh6, Gtmbp, GTBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17688
VEGA: 17
HGNC: HGNC:7329
Homologene: 149
Hnrnpm
Name: heterogeneous nuclear ribonucleoprotein M
Synonyms: 2610023M21Rik, Hnrpm
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 76936
HGNC: HGNC:5046
Homologene: 4354
Trpm4
Name: transient receptor potential cation channel, subfamily M, member 4
Synonyms: 1110030C19Rik, LTRPC4, TRPM4B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68667
Homologene: 23033
Egfr
Name: epidermal growth factor receptor
Synonyms: Errb1, Erbb, 9030024J15Rik, avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, Wa5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 13649
HGNC: HGNC:3236
Homologene: 74545
Nefm
Name: neurofilament, medium polypeptide
Synonyms: NF165, neurofilament-M, Nfm, NF160, NF-M, Nef3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 18040
HGNC: HGNC:7734
Homologene: 137211
Hspa9
Name: heat shock protein 9
Synonyms: Hsp74a, mot-2, Hsc74, C3H-specific antigen, CSA, mortalin, mthsp70, Hspa9a, PBP74, GRP75, Hsp74
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 15526
HGNC: HGNC:5244
Homologene: 39452
Tecpr2
Name: tectonin beta-propeller repeat containing 2
Synonyms: 4930573I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104859
VEGA: 12
Homologene: 8897
Tbc1d32
Name: TBC1 domain family, member 32
Synonyms: C6orf170, D630037F22Rik, Bromi, b2b2284Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 544696
VEGA: 10
Homologene: 51889
Grin1
Name: glutamate receptor, ionotropic, NMDA1 (zeta 1)
Synonyms: GluRzeta1, Nmdar, NR1, Rgsc174, NMDAR1, M100174
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 14810
HGNC: HGNC:4584
Homologene: 7187
Tatdn2
Name: TatD DNase domain containing 2
Synonyms: mKIAA0218
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 381801
Homologene: 8848
Tns2
Name: tensin 2
Synonyms: Tenc1, nep, nph
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 209039
VEGA: 15
Homologene: 37077
Plcb3
Name: phospholipase C, beta 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18797
VEGA: 19
HGNC: HGNC:9056
Homologene: 47960
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 15496
Homologene: 104115
Tdrd5
Name: tudor domain containing 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 214575
Homologene: 18312
Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
Synonyms: Arhgap13, 4930572H05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 117600
Homologene: 56898
Itgad
Name: integrin, alpha D
Synonyms: Cd11d
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381924
HGNC: HGNC:6146
Homologene: 56919
Ripk2
Name: receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms: 2210420D18Rik, CCK, CARDIAK, RIP2, RICK, D4Bwg0615e, CARD3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 192656
Homologene: 37856
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: Slo1, mSlo1, MaxiK, Slo, BK channel alpha subunit, BKCa, 5730414M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Dcaf17
Name: DDB1 and CUL4 associated factor 17
Synonyms: A030004A10Rik, 4833418A01Rik, 2810055O12Rik, A930009G19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75763
Homologene: 65979
Aldh3a2
Name: aldehyde dehydrogenase family 3, subfamily A2
Synonyms: FALDH, Ahd3, Ahd3-r, Aldh4-r, Ahd-3r, Ahd-3, Aldh4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11671
HGNC: HGNC:403
Homologene: 55458
Mmp1b
Name: matrix metallopeptidase 1b (interstitial collagenase)
Synonyms: Mcol-B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 83996
HGNC: HGNC:7155
Homologene: 130791
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: Wdr67, D330013L20Rik, LOC210544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 210544
Homologene: 17089
Mast1
Name: microtubule associated serine/threonine kinase 1
Synonyms: SAST170, 9430008B02Rik, SAST
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56527
Homologene: 10543
Psg28
Name: pregnancy-specific glycoprotein 28
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 114871
Homologene: 110989
Slc5a9
Name: solute carrier family 5 (sodium/glucose cotransporter), member 9
Synonyms: SGLT4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230612
Homologene: 17081
Bfsp2
Name: beaded filament structural protein 2, phakinin
Synonyms: CP49
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 107993
HGNC: HGNC:1041
Homologene: 20791
Adamts5
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Synonyms: 9530092O11Rik, ADAM-TS5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 23794
VEGA: 16
HGNC: HGNC:221
Homologene: 5109
Pex13
Name: peroxisomal biogenesis factor 13
Synonyms: 2610008O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 72129
HGNC: HGNC:8855
Homologene: 1967
Tll1
Name: tolloid-like
Synonyms: b2b2476Clo, Tll-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 21892
Homologene: 49202
Atxn7l2
Name: ataxin 7-like 2
Synonyms: 2610528J18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 72522
Homologene: 17728
Antxrl
Name: anthrax toxin receptor-like
Synonyms: 1700112N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 239029
VEGA: 14
Homologene: 52111
Ggt5
Name: gamma-glutamyltransferase 5
Synonyms: GGL, gamma-glutamyl leukotrienase, GGT-REL, Ggtla1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 23887
HGNC: HGNC:4260
Homologene: 55802
Tbc1d21
Name: TBC1 domain family, member 21
Synonyms: 1700095K08Rik, MgcRabGAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 74286
VEGA: 9
Homologene: 14033
Gdpd1
Name: glycerophosphodiester phosphodiesterase domain containing 1
Synonyms: 2610020H15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66569
Homologene: 7069
Ly6i
Name: lymphocyte antigen 6 complex, locus I
Synonyms: Ly-6I, Ly-6M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 57248
Homologene: 113718
Lipf
Name: lipase, gastric
Synonyms: 2310051B21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67717
HGNC: HGNC:6622
Homologene: 68139
Gm11060
Name: predicted gene 11060
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Olfr156
Name: olfactory receptor 156
Synonyms: mOR37b, MOR262-6, Olfr37b, OR37B, GA_x6K02T2N78B-16125144-16126100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 29846
Homologene: 133652
Snrpa
Name: small nuclear ribonucleoprotein polypeptide A
Synonyms: U1 snRNP, C430021M15Rik, Rnu1a1, U1A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53607
Homologene: 133537
Gpr132
Name: G protein-coupled receptor 132
Synonyms: G2a, G2 accumulation
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 56696
VEGA: 12
Homologene: 8350
Ankdd1b
Name: ankyrin repeat and death domain containing 1B
Synonyms: 9330128J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 271144
Homologene: 19566
Pxt1
Name: peroxisomal, testis specific 1
Synonyms: 1700001G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 69307
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 89,837,806 bp
  • G to C, chromosome 1 at 156,259,836 bp
  • A to T, chromosome 1 at 165,515,380 bp
  • G to A, chromosome 2 at 25,292,430 bp
  • A to G, chromosome 2 at 71,073,173 bp
  • A to G, chromosome 2 at 105,093,752 bp
  • A to G, chromosome 2 at 118,122,672 bp
  • T to C, chromosome 2 at 152,257,427 bp
  • G to A, chromosome 3 at 98,619,530 bp
  • A to G, chromosome 3 at 108,208,432 bp
  • G to A, chromosome 4 at 16,163,239 bp
  • A to G, chromosome 4 at 43,302,590 bp
  • A to T, chromosome 4 at 43,820,639 bp
  • A to G, chromosome 4 at 111,883,964 bp
  • C to T, chromosome 5 at 86,013,510 bp
  • T to C, chromosome 5 at 135,438,632 bp
  • T to A, chromosome 5 at 135,984,188 bp
  • G to C, chromosome 6 at 83,197,508 bp
  • T to A, chromosome 6 at 113,704,327 bp
  • A to T, chromosome 7 at 18,427,964 bp
  • T to C, chromosome 7 at 27,192,937 bp
  • T to C, chromosome 7 at 45,317,056 bp
  • T to C, chromosome 7 at 128,192,137 bp
  • T to C, chromosome 7 at 134,851,609 bp
  • T to A, chromosome 8 at 3,603,968 bp
  • A to G, chromosome 8 at 64,038,490 bp
  • G to A, chromosome 8 at 84,920,635 bp
  • G to C, chromosome 9 at 7,386,693 bp
  • A to G, chromosome 9 at 58,362,813 bp
  • G to A, chromosome 9 at 75,263,066 bp
  • A to T, chromosome 9 at 103,480,225 bp
  • A to T, chromosome 10 at 56,177,479 bp
  • A to T, chromosome 10 at 75,609,908 bp
  • T to A, chromosome 10 at 121,896,738 bp
  • A to T, chromosome 11 at 16,889,920 bp
  • A to G, chromosome 11 at 23,649,422 bp
  • A to G, chromosome 11 at 61,265,102 bp
  • A to G, chromosome 11 at 80,032,113 bp
  • T to G, chromosome 11 at 87,059,509 bp
  • A to G, chromosome 12 at 110,968,953 bp
  • G to A, chromosome 12 at 112,852,240 bp
  • A to T, chromosome 13 at 96,433,405 bp
  • T to C, chromosome 14 at 23,463,200 bp
  • G to A, chromosome 14 at 34,060,949 bp
  • A to G, chromosome 14 at 68,121,379 bp
  • T to A, chromosome 15 at 57,951,638 bp
  • G to A, chromosome 15 at 73,025,967 bp
  • T to C, chromosome 15 at 74,983,055 bp
  • A to G, chromosome 15 at 98,604,728 bp
  • C to T, chromosome 15 at 102,108,934 bp
  • A to G, chromosome 16 at 85,869,993 bp
  • C to A, chromosome 17 at 28,934,782 bp
  • A to G, chromosome 17 at 33,666,488 bp
  • A to G, chromosome 17 at 87,984,758 bp
  • A to T, chromosome 18 at 34,938,606 bp
  • T to C, chromosome 19 at 6,481,446 bp
  • T to C, chromosome 19 at 6,955,046 bp
  • C to T, chromosome 19 at 33,970,732 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1454 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039509-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.