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Strain Name:
C57BL/6J-MtgxR1456Btlr/Mmmh
Stock Number:
039511-MU
Citation ID:
RRID:MMRRC_039511-MU
Other Names:
R1456 (G1), C57BL/6J-MtgxR1456Btlr
Major Collection:

Strain Information

Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269132
Homologene: 22865
Ranbp17
Name: RAN binding protein 17
Synonyms: 4932704E15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66011
Homologene: 36409
Sptan1
Name: spectrin alpha, non-erythrocytic 1
Synonyms: alpha-fodrin, Spna-2, 2610027H02Rik, Spna2, alphaII-spectrin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20740
Homologene: 2353
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Hira
Name: histone cell cycle regulator
Synonyms: Tuple1, D16Ertd95e, Gm15797
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Pafah2
Name: platelet-activating factor acetylhydrolase 2
Synonyms: 2310074E22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100163
HGNC: HGNC:8579
Homologene: 37309
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4930470P14Rik, 9530057A13Rik, 4932439K10Rik, Specc1l, Cytsa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74392
VEGA: 10
Homologene: 15610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 32,520,696 bp
  • A to T, chromosome 1 at 72,665,118 bp
  • C to A, chromosome 1 at 75,487,656 bp
  • G to A, chromosome 1 at 152,484,904 bp
  • A to T, chromosome 1 at 153,465,695 bp
  • C to T, chromosome 2 at 19,480,920 bp
  • G to T, chromosome 2 at 29,980,203 bp
  • A to T, chromosome 2 at 68,716,214 bp
  • A to G, chromosome 2 at 94,001,419 bp
  • G to T, chromosome 2 at 104,208,083 bp
  • A to G, chromosome 2 at 106,351,565 bp
  • C to T, chromosome 2 at 119,973,145 bp
  • G to A, chromosome 4 at 106,695,141 bp
  • C to A, chromosome 4 at 133,297,428 bp
  • T to A, chromosome 4 at 134,404,157 bp
  • T to G, chromosome 4 at 139,965,524 bp
  • G to T, chromosome 4 at 143,993,281 bp
  • T to C, chromosome 5 at 44,037,623 bp
  • G to T, chromosome 5 at 134,657,510 bp
  • T to C, chromosome 5 at 137,137,951 bp
  • A to G, chromosome 5 at 144,011,018 bp
  • A to G, chromosome 5 at 145,220,988 bp
  • C to T, chromosome 6 at 52,744,244 bp
  • A to T, chromosome 6 at 85,924,421 bp
  • A to T, chromosome 6 at 100,669,698 bp
  • C to G, chromosome 6 at 123,637,665 bp
  • T to C, chromosome 6 at 125,145,914 bp
  • T to A, chromosome 6 at 136,613,816 bp
  • G to A, chromosome 7 at 44,105,499 bp
  • G to T, chromosome 7 at 44,306,450 bp
  • A to T, chromosome 7 at 46,647,483 bp
  • A to T, chromosome 7 at 48,448,029 bp
  • A to T, chromosome 7 at 66,043,535 bp
  • T to C, chromosome 7 at 67,667,154 bp
  • C to A, chromosome 7 at 81,559,591 bp
  • T to A, chromosome 7 at 83,998,510 bp
  • C to T, chromosome 7 at 99,664,907 bp
  • A to G, chromosome 7 at 107,990,398 bp
  • A to G, chromosome 7 at 120,047,630 bp
  • T to C, chromosome 7 at 126,880,141 bp
  • A to C, chromosome 8 at 11,242,829 bp
  • A to G, chromosome 8 at 70,331,188 bp
  • G to T, chromosome 8 at 70,746,613 bp
  • T to C, chromosome 8 at 122,841,948 bp
  • T to C, chromosome 9 at 20,300,838 bp
  • T to C, chromosome 9 at 119,691,478 bp
  • C to T, chromosome 10 at 3,260,307 bp
  • T to A, chromosome 10 at 24,903,652 bp
  • T to C, chromosome 10 at 26,916,440 bp
  • T to C, chromosome 10 at 41,464,993 bp
  • T to C, chromosome 10 at 60,487,120 bp
  • T to C, chromosome 10 at 75,246,284 bp
  • A to T, chromosome 10 at 129,387,783 bp
  • A to G, chromosome 11 at 16,863,065 bp
  • A to G, chromosome 11 at 32,415,967 bp
  • A to G, chromosome 11 at 33,266,310 bp
  • A to T, chromosome 11 at 60,508,202 bp
  • G to T, chromosome 11 at 82,753,620 bp
  • G to A, chromosome 11 at 94,653,833 bp
  • G to A, chromosome 11 at 100,269,609 bp
  • C to T, chromosome 11 at 100,269,610 bp
  • A to G, chromosome 11 at 115,845,499 bp
  • C to T, chromosome 12 at 3,501,872 bp
  • C to T, chromosome 12 at 65,118,351 bp
  • T to C, chromosome 13 at 22,852,245 bp
  • C to T, chromosome 13 at 98,075,002 bp
  • A to G, chromosome 14 at 30,892,653 bp
  • A to T, chromosome 14 at 101,507,106 bp
  • A to T, chromosome 15 at 27,753,804 bp
  • A to T, chromosome 15 at 41,102,481 bp
  • T to C, chromosome 15 at 79,530,376 bp
  • T to C, chromosome 16 at 10,691,555 bp
  • T to G, chromosome 16 at 18,925,663 bp
  • T to A, chromosome 16 at 92,320,665 bp
  • A to T, chromosome 17 at 22,007,118 bp
  • A to T, chromosome 17 at 24,906,949 bp
  • A to G, chromosome 17 at 40,905,178 bp
  • A to G, chromosome 17 at 55,490,931 bp
  • A to G, chromosome 17 at 74,609,290 bp
  • A to T, chromosome 18 at 22,150,424 bp
  • A to G, chromosome 18 at 33,129,843 bp
  • A to G, chromosome 18 at 60,713,205 bp
  • T to A, chromosome 19 at 8,071,858 bp
  • A to G, chromosome 19 at 8,740,412 bp
  • A to G, chromosome 19 at 10,185,752 bp
  • T to A, chromosome 19 at 10,964,733 bp
  • T to A, chromosome 19 at 33,465,873 bp
  • C to T, chromosome 19 at 34,046,785 bp
  • T to C, chromosome 19 at 59,300,472 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1456 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039511-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.