Strain Name:
C57BL/6J-MtgxR1493Btlr/Mmmh
Stock Number:
039544-MU
Citation ID:
RRID:MMRRC_039544-MU
Other Names:
R1493 (G1), C57BL/6J-MtgxR1493Btlr
Major Collection:

Gene Information

Uchl3
Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 50933
VEGA: 14
Homologene: 4377
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 22359
Homologene: 443
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, trp2, mTrp2, 3010009O07Rik, Trrp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 22064
Homologene: 135989
Cbfa2t2
Name: CBFA2/RUNX1 translocation partner 2
Synonyms: C330013D05Rik, MTGR1, Cbfa2t2h
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12396
HGNC: HGNC:1536
Homologene: 3733
Zic1
Name: zinc finger protein of the cerebellum 1
Synonyms: odd-paired homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 22771
Homologene: 2562
Rnmt
Name: RNA (guanine-7-) methyltransferase
Synonyms: 2610002P10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67897
Homologene: 2816
Cep290
Name: centrosomal protein 290
Synonyms: b2b1454Clo, b2b1752Clo, Kiaa, Nphp6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Helz
Name: helicase with zinc finger domain
Synonyms: 9430093I07Rik, 3110078M01Rik, 9630002H22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 78455
Homologene: 8918
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, Cxxc7, HTRX1, Mll1, ALL-1, All1, trithorax Drosophila
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Tasor
Name: transcription activation suppressor
Synonyms: 4933409E02Rik, Fam208a, MommeD6, D14Abb1e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218850
VEGA: 14
Homologene: 9062
Abcg8
Name: ATP binding cassette subfamily G member 8
Synonyms: Sterolin-2, 1300003C16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 67470
Homologene: 23361
Arid1b
Name: AT rich interactive domain 1B (SWI-like)
Synonyms: 9330189K18Rik, B230217J03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 239985
Homologene: 32344
Arhgap42
Name: Rho GTPase activating protein 42
Synonyms: 9030420J04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 71544
Homologene: 28446
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C030046E11Rik, C130057E09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 226089
Homologene: 13806
Ankrd27
Name: ankyrin repeat domain 27 (VPS9 domain)
Synonyms: D330003H11Rik, Varp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 245886
Homologene: 12956
Vps18
Name: VPS18 CORVET/HOPS core subunit
Synonyms: 9930024E13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228545
Homologene: 13302
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233878
Homologene: 8237
2810021J22Rik
Name: RIKEN cDNA 2810021J22 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 69944
Homologene: 138400
Ablim2
Name: actin-binding LIM protein 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231148
Homologene: 82366
Prkag1
Name: protein kinase, AMP-activated, gamma 1 non-catalytic subunit
Synonyms: Prkaac
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 19082
VEGA: 15
HGNC: HGNC:9385
Homologene: 99712
Morc2a
Name: microrchidia 2A
Synonyms: Zcwcc1, 8430403M08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 74522
Homologene: 8966
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216565
Homologene: 22880
Cars2
Name: cysteinyl-tRNA synthetase 2 (mitochondrial)(putative)
Synonyms: 2310051N18Rik, 2410044A07Rik, D530030H10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 71941
Homologene: 11575
Rsph1
Name: radial spoke head 1 homolog (Chlamydomonas)
Synonyms: meichroacidin, Tsga2, MCA
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 22092
VEGA: 17
Homologene: 11905
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK1, 7420452D20Rik, Mekk5, ASK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: LOC381229, Ccdc147
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Gm9833
Name: predicted gene 9833
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 100041480
Unc13c
Name: unc-13 homolog C
Synonyms: Munc13-3, Unc13h3, D9Ertd414e, 1500037O19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 208898
Homologene: 45443
Tpo
Name: thyroid peroxidase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 22018
Homologene: 461
Fgd5
Name: FYVE, RhoGEF and PH domain containing 5
Synonyms: ZFYVE23, C330025N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 232237
Homologene: 27798
Abca15
Name: ATP-binding cassette, sub-family A (ABC1), member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320631
Homologene: 87255
Olfr670
Name: olfactory receptor 670
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 384703
Homologene: 105163
Tmem175
Name: transmembrane protein 175
Synonyms: 3010001K23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 72392
Homologene: 12461
Shmt2
Name: serine hydroxymethyltransferase 2 (mitochondrial)
Synonyms: 2700043D08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 108037
VEGA: 10
Homologene: 133984
AC138665.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Folh1
Name: folate hydrolase 1
Synonyms: GCP2, glutamate carboxypeptidase II, mopsm, prostate-specific membrane antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 53320
HGNC: HGNC:3788
Homologene: 55826
Thap12
Name: THAP domain containing 12
Synonyms: 2900052B10Rik, Dap4, Prkrir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72981
HGNC: HGNC:9440
Homologene: 37952
Nod1
Name: nucleotide-binding oligomerization domain containing 1
Synonyms: Nlrc1, F830007N14Rik, Card4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 107607
Homologene: 4440
Rfc4
Name: replication factor C (activator 1) 4
Synonyms: A1, RFC37
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 106344
HGNC: HGNC:9972
Homologene: 6288
Arfgef3
Name: ARFGEF family member 3
Synonyms: B930094H20Rik, BIG3, D10Bwg1379e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 215821
VEGA: 10
Homologene: 41366
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 76390
Homologene: 88945
Ninl
Name: ninein-like
Synonyms: 4930519N13Rik, LOC381387, LOC381388
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 78177
Homologene: 57024
Notch4
Name: notch 4
Synonyms: N4, Int3, Int-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 18132
HGNC: HGNC:7884
Homologene: 3351
Hexdc
Name: hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 238023
Homologene: 68120
Nsd3
Name: nuclear receptor binding SET domain protein 3
Synonyms: Whsc1l1, WHISTLE
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234135
Homologene: 56960
Axdnd1
Name: axonemal dynein light chain domain containing 1
Synonyms: LOC381304, 9430070O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 77352
Homologene: 52328
AC149051.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Adprm
Name: ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
Synonyms: 2310004I24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 66358
Homologene: 10632
Tmprss13
Name: transmembrane protease, serine 13
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 214531
Homologene: 12936
Stk25
Name: serine/threonine kinase 25 (yeast)
Synonyms: Ste20-like, Ysk1, 1500019J11Rik, SOK-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 59041
Homologene: 48428
Fam129a
Name: family with sequence similarity 129, member A
Synonyms: Niban
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 63913
Homologene: 62170
Zfp692
Name: zinc finger protein 692
Synonyms: Zfp692-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 103836
Homologene: 9889
Med14
Name: mediator complex subunit 14
Synonyms: ORF1, Crsp2, Trap170, ENSMUSG00000073278, LOC270579, 9930001L01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 26896
HGNC: HGNC:2370
Homologene: 22082
Olfr555
Name: olfactory receptor 555
Synonyms: MOR10-1, GA_x6K02T2PBJ9-5375442-5376389
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 259107
Homologene: 51817
Hrh1
Name: histamine receptor H1
Synonyms: Bphs, Hir
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 15465
HGNC: HGNC:5182
Homologene: 668
Cd7
Name: CD7 antigen
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 12516
HGNC: HGNC:1695
Homologene: 4471
Cep44
Name: centrosomal protein 44
Synonyms: 4933440G23Rik, BC088983
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 382010
Homologene: 12738
Musk
Name: muscle, skeletal, receptor tyrosine kinase
Synonyms: Nsk3, MDK4, Nsk2, Nsk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 18198
HGNC: HGNC:7525
Homologene: 4084
Sorbs3
Name: sorbin and SH3 domain containing 3
Synonyms: Sh3d4, vinexin beta, vinexin alpha, SH3P3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 20410
VEGA: 14
Homologene: 4218
Hs3st5
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 5
Synonyms: LOC382362, D930005L05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 319415
Homologene: 17796
Iqcf6
Name: IQ motif containing F6
Synonyms: 100041096
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 100041096
Homologene: 67808
Nans
Name: N-acetylneuraminic acid synthase (sialic acid synthase)
Synonyms: 4632418E04Rik, N-acetylneuraminic acid phosphate synthase, Sas
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 94181
Homologene: 10343
Gstm6
Name: glutathione S-transferase, mu 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 14867
Homologene: 117950
Gm8374
Name: predicted gene 8374
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Orai3
Name: ORAI calcium release-activated calcium modulator 3
Synonyms: Tmem142c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 269999
Homologene: 72082
Gm4559
Name: predicted gene 4559
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100043627
VEGA: 7
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,625,600 bp
  • T to A, chromosome 1 at 151,706,090 bp
  • T to A, chromosome 1 at 156,346,701 bp
  • A to G, chromosome 2 at 119,297,132 bp
  • T to G, chromosome 2 at 150,980,095 bp
  • T to C, chromosome 2 at 154,521,139 bp
  • A to G, chromosome 3 at 10,088,884 bp
  • G to C, chromosome 3 at 59,606,654 bp
  • A to G, chromosome 3 at 107,942,781 bp
  • G to A, chromosome 4 at 46,500,761 bp
  • C to T, chromosome 4 at 58,354,003 bp
  • T to C, chromosome 5 at 35,809,261 bp
  • T to A, chromosome 5 at 108,638,498 bp
  • A to G, chromosome 6 at 54,944,056 bp
  • A to G, chromosome 6 at 91,987,631 bp
  • G to A, chromosome 6 at 114,480,877 bp
  • C to T, chromosome 7 at 35,608,365 bp
  • T to C, chromosome 7 at 86,761,730 bp
  • A to G, chromosome 7 at 98,715,438 bp
  • A to T, chromosome 7 at 102,090,576 bp
  • T to C, chromosome 7 at 102,659,013 bp
  • T to A, chromosome 7 at 104,960,502 bp
  • A to T, chromosome 7 at 120,382,290 bp
  • C to A, chromosome 7 at 126,961,812 bp
  • G to A, chromosome 7 at 127,773,905 bp
  • A to T, chromosome 7 at 142,274,313 bp
  • A to T, chromosome 8 at 11,517,817 bp
  • A to G, chromosome 8 at 25,713,380 bp
  • A to G, chromosome 8 at 56,532,835 bp
  • A to G, chromosome 8 at 63,926,855 bp
  • T to G, chromosome 9 at 9,030,797 bp
  • A to T, chromosome 9 at 44,846,905 bp
  • A to G, chromosome 9 at 45,336,107 bp
  • T to C, chromosome 9 at 73,639,068 bp
  • A to G, chromosome 9 at 91,364,756 bp
  • T to C, chromosome 9 at 106,627,442 bp
  • A to G, chromosome 10 at 18,630,879 bp
  • A to G, chromosome 10 at 20,029,113 bp
  • G to A, chromosome 10 at 36,832,874 bp
  • A to T, chromosome 10 at 100,562,181 bp
  • A to G, chromosome 10 at 127,518,943 bp
  • A to G, chromosome 11 at 3,678,557 bp
  • T to A, chromosome 11 at 22,006,866 bp
  • A to T, chromosome 11 at 58,314,040 bp
  • T to C, chromosome 11 at 58,876,718 bp
  • A to G, chromosome 11 at 67,041,876 bp
  • G to A, chromosome 11 at 73,710,479 bp
  • A to G, chromosome 11 at 107,613,925 bp
  • T to C, chromosome 11 at 121,038,141 bp
  • A to G, chromosome 11 at 121,221,267 bp
  • A to T, chromosome 12 at 30,131,809 bp
  • T to C, chromosome 14 at 7,364,216 bp
  • A to G, chromosome 14 at 27,449,969 bp
  • T to C, chromosome 14 at 70,192,627 bp
  • A to G, chromosome 14 at 101,695,887 bp
  • T to C, chromosome 15 at 98,813,670 bp
  • T to C, chromosome 16 at 23,118,008 bp
  • T to A, chromosome 17 at 5,321,261 bp
  • C to T, chromosome 17 at 31,265,899 bp
  • T to A, chromosome 17 at 34,567,682 bp
  • T to C, chromosome 17 at 84,696,679 bp
  • G to A, chromosome 18 at 68,313,707 bp
  • A to G, chromosome 19 at 27,241,291 bp
  • T to C, chromosome 19 at 29,579,849 bp
  • C to T, chromosome 19 at 47,988,504 bp
  • A to G, chromosome X at 12,713,570 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1493 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039544-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.