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Strain Name:
C57BL/6J-MtgxR1556Btlr/Mmmh
Stock Number:
039595-MU
Citation ID:
RRID:MMRRC_039595-MU
Other Names:
R1556 (G1), C57BL/6J-MtgxR1556Btlr
Major Collection:

Strain Information

Aven
Name: apoptosis, caspase activation inhibitor
Synonyms: 1700013A01Rik, mAven-S, mAven-L, 1700056A21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74268
Homologene: 10683
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Slc4a7
Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7
Synonyms: E430014N10Rik, NBC3, NBCn1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218756
VEGA: 14
Homologene: 2680
Arhgef6
Name: Rac/Cdc42 guanine nucleotide exchange factor 6
Synonyms: 1700038J06Rik, 1600028C08Rik, 4930592P22Rik, alpha-PIX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: X
NCBI: 73341
HGNC: HGNC:685
Homologene: 3561
Rgs12
Name: regulator of G-protein signaling 12
Synonyms: 4632412M04Rik, 1200016K18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71729
HGNC: HGNC:9994
Homologene: 2195
L3mbtl2
Name: L3MBTL2 polycomb repressive complex 1 subunit
Synonyms: 4732493N06Rik, m4mbt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 214669
Homologene: 12882
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,320,164 bp
  • C to T, chromosome 1 at 54,417,778 bp
  • C to T, chromosome 1 at 66,521,581 bp
  • T to A, chromosome 1 at 72,259,383 bp
  • T to C, chromosome 1 at 135,232,859 bp
  • C to T, chromosome 1 at 153,906,499 bp
  • A to G, chromosome 1 at 166,398,833 bp
  • G to A, chromosome 2 at 112,630,885 bp
  • T to C, chromosome 2 at 128,624,899 bp
  • A to G, chromosome 3 at 95,529,568 bp
  • A to G, chromosome 3 at 105,986,752 bp
  • A to G, chromosome 4 at 107,217,813 bp
  • T to C, chromosome 4 at 123,455,020 bp
  • A to G, chromosome 5 at 21,330,553 bp
  • G to A, chromosome 5 at 31,534,210 bp
  • A to G, chromosome 5 at 35,039,282 bp
  • A to T, chromosome 5 at 96,743,062 bp
  • T to A, chromosome 5 at 148,077,388 bp
  • A to G, chromosome 6 at 4,538,622 bp
  • A to T, chromosome 6 at 127,130,400 bp
  • T to C, chromosome 7 at 31,044,567 bp
  • T to C, chromosome 7 at 35,295,351 bp
  • C to A, chromosome 7 at 66,710,637 bp
  • T to A, chromosome 7 at 104,084,261 bp
  • G to A, chromosome 8 at 25,861,191 bp
  • T to C, chromosome 8 at 72,449,633 bp
  • T to C, chromosome 8 at 124,030,617 bp
  • T to A, chromosome 9 at 65,051,479 bp
  • T to C, chromosome 9 at 67,930,711 bp
  • T to C, chromosome 9 at 83,594,698 bp
  • T to C, chromosome 9 at 89,175,390 bp
  • A to G, chromosome 9 at 96,686,991 bp
  • A to T, chromosome 9 at 97,456,505 bp
  • A to G, chromosome 9 at 105,709,473 bp
  • C to T, chromosome 9 at 106,475,008 bp
  • G to A, chromosome 10 at 64,088,149 bp
  • T to C, chromosome 10 at 129,776,373 bp
  • T to C, chromosome 11 at 5,281,347 bp
  • A to G, chromosome 11 at 54,125,010 bp
  • A to G, chromosome 11 at 62,592,233 bp
  • A to G, chromosome 11 at 67,245,825 bp
  • T to A, chromosome 11 at 69,665,850 bp
  • T to A, chromosome 11 at 72,915,233 bp
  • T to A, chromosome 11 at 74,288,936 bp
  • T to C, chromosome 11 at 101,414,111 bp
  • T to C, chromosome 11 at 120,612,085 bp
  • T to C, chromosome 12 at 8,301,698 bp
  • T to A, chromosome 12 at 66,550,593 bp
  • T to G, chromosome 12 at 111,627,841 bp
  • T to C, chromosome 13 at 59,800,240 bp
  • T to A, chromosome 13 at 104,139,776 bp
  • T to C, chromosome 14 at 14,778,872 bp
  • G to A, chromosome 14 at 50,084,459 bp
  • T to C, chromosome 14 at 50,853,042 bp
  • T to G, chromosome 14 at 79,086,681 bp
  • T to G, chromosome 14 at 79,770,403 bp
  • T to A, chromosome 15 at 81,682,002 bp
  • A to G, chromosome 15 at 101,861,278 bp
  • A to T, chromosome 16 at 9,707,715 bp
  • A to T, chromosome 16 at 10,446,998 bp
  • T to A, chromosome 16 at 20,655,585 bp
  • G to T, chromosome 16 at 29,579,585 bp
  • G to T, chromosome 16 at 32,670,919 bp
  • C to T, chromosome 16 at 57,316,197 bp
  • G to A, chromosome 16 at 59,461,400 bp
  • A to G, chromosome 16 at 96,021,352 bp
  • A to T, chromosome 17 at 34,284,416 bp
  • T to C, chromosome 17 at 36,773,313 bp
  • A to G, chromosome 17 at 46,250,867 bp
  • A to G, chromosome 18 at 12,744,780 bp
  • T to C, chromosome 19 at 30,624,743 bp
  • T to C, chromosome 19 at 45,009,411 bp
  • A to G, chromosome 19 at 55,076,331 bp
  • T to C, chromosome X at 57,338,562 bp
  • T to C, chromosome X at 113,298,517 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1556 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039595-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.