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Strain Name:
C57BL/6J-MtgxR1559Btlr/Mmmh
Stock Number:
039598-MU
Citation ID:
RRID:MMRRC_039598-MU
Other Names:
R1559 (G1), C57BL/6J-MtgxR1559Btlr
Major Collection:

Strain Information

Hmox1
Name: heme oxygenase 1
Synonyms: Hsp32, HO-1, heme oxygenase 1, D8Wsu38e, Hmox, HO1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15368
HGNC: HGNC:5013
Homologene: 31075
Drd1
Name: dopamine receptor D1
Synonyms: D1 receptor, Gpcr15, Drd-1, C030036C15Rik, Drd1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13488
VEGA: 13
HGNC: HGNC:3020
Homologene: 30992
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Il4i1
Name: interleukin 4 induced 1
Synonyms: Fig1-ps, Fig1, H46, H4, H-46, H-4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14204
Homologene: 22567
Cdc6
Name: cell division cycle 6
Synonyms: cell division cycle 18 homolog (S.pombe)-like, CDC18L, CDC18(S.pombe)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23834
HGNC: HGNC:1744
Homologene: 68172
Ccna2
Name: cyclin A2
Synonyms: Cyca, Ccn1, Ccn-1, Ccna, CycA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12428
HGNC: HGNC:1578
Homologene: 55562
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: apollon, Bruce, A430032G04Rik, D630005A10Rik, A430040A19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Sf3b1
Name: splicing factor 3b, subunit 1
Synonyms: SAP155, Prp10, SF3b155, 2810001M05Rik, Targ4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 81898
Homologene: 6696
Ccdc93
Name: coiled-coil domain containing 93
Synonyms: 9230102M16Rik, 4633402D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70829
Homologene: 10393
Camsap2
Name: calmodulin regulated spectrin-associated protein family, member 2
Synonyms: 1600013L13Rik, 4930541M15Rik, Camsap1l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67886
Homologene: 18927
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 208836
Homologene: 49530
M6pr
Name: mannose-6-phosphate receptor, cation dependent
Synonyms: Mpr46, CD-MPR
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17113
HGNC: HGNC:6752
Homologene: 31086
Dgkd
Name: diacylglycerol kinase, delta
Synonyms: DGKdelta, dgkd-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227333
HGNC: HGNC:2851
Homologene: 100054
Cftr
Name: cystic fibrosis transmembrane conductance regulator
Synonyms: Abcc7
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12638
HGNC: HGNC:1884
Homologene: 55465
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12032
Homologene: 7244
Pcx
Name: pyruvate carboxylase
Synonyms: Pc
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18563
VEGA: 19
HGNC: HGNC:8636
Homologene: 5422
Heyl
Name: hairy/enhancer-of-split related with YRPW motif-like
Synonyms: Hrt3, Hey3, Hesr3, bHLHb33
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56198
HGNC: HGNC:4882
Homologene: 8494
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: ST8SiaV, Siat8e
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225742
Homologene: 8331
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Cenpe
Name: centromere protein E
Synonyms: N-7 kinesin, CENP-E, 312kDa, Kif10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, Hapip, 2210407G14Rik, E530005C20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
Lrrc4c
Name: leucine rich repeat containing 4C
Synonyms: 6430556C10Rik, netrin g1 ligand, NGL-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241568
Homologene: 18696
Dclk3
Name: doublecortin-like kinase 3
Synonyms: Click-I, -II related, Dcamkl3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245038
Homologene: 70580
Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
Synonyms: D530030H10Rik, 2310051N18Rik, 2410044A07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71941
Homologene: 11575
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, nmf252, bob, nmf112, nmf181, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: IL-12RB2, Ifnm, A930027I18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Stk32a
Name: serine/threonine kinase 32A
Synonyms: YANK1, A930015B13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269019
VEGA: 18
Homologene: 65357
Drc3
Name: dynein regulatory complex subunit 3
Synonyms: 4930449E07Rik, m6Bei, Lrrc48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74665
Homologene: 12581
Or51ab3
Name: olfactory receptor family 51 subfamily AB member 3
Synonyms: GA_x6K02T2PBJ9-6271959-6272393, GA_x6K02T2PBJ9-6275524-6276477, MOR20-1, MOR20-1, Olfr614, Olfr613
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259104
Homologene: 17505
Grik3
Name: glutamate receptor, ionotropic, kainate 3
Synonyms: Glur-7, Glur7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14807
HGNC: HGNC:4581
Homologene: 73901
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68915
Homologene: 57502
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212892
Homologene: 71779
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Or1j17
Name: olfactory receptor family 1 subfamily J member 17
Synonyms: GA_x6K02T2NLDC-33382467-33383396, MOR136-11, Olfr346
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258940
Homologene: 133616
Traf3ip3
Name: TRAF3 interacting protein 3
Synonyms: 6030423D04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215243
Homologene: 11885
Or8g23
Name: olfactory receptor family 8 subfamily G member 23
Synonyms: GA_x6K02T2PVTD-32756567-32755632, MOR171-24, Olfr937
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258431
VEGA: 9
HGNC: HGNC:8484
Homologene: 27167
Ppox
Name: protoporphyrinogen oxidase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19044
HGNC: HGNC:9280
Homologene: 262
Daam2
Name: dishevelled associated activator of morphogenesis 2
Synonyms: 2310016D11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76441
VEGA: 17
Homologene: 69186
Unc45b
Name: unc-45 myosin chaperone B
Synonyms: UNC45, D230041A13Rik, Cmya4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217012
Homologene: 14666
Saxo4
Name: stabilizer of axonemal microtubules 4
Synonyms: IIIG9L, IIIG9, IIIG9S, 4930579J09Rik, Ppp1r32
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Babam1
Name: BRISC and BRCA1 A complex member 1
Synonyms: 5430437P03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68251
Homologene: 8574
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231147
Homologene: 10360
Tmem129
Name: transmembrane protein 129
Synonyms: 2410015J15Rik, 0610039G24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68366
Homologene: 44528
Cyp4a12b
Name: cytochrome P450, family 4, subfamily a, polypeptide 12B
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13118
Homologene: 134044
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Prb1a
Name: proline-rich protein BstNI subfamily 1A
Synonyms: proline-rich proteoglycan 2, Prb1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381833
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Ajm1
Name: apical junction component 1
Synonyms: LOC381353, Gm996
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381353
Homologene: 19943
Smpdl3a
Name: sphingomyelin phosphodiesterase, acid-like 3A
Synonyms: 0610010C24Rik, ASM3A, ASML3A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57319
Homologene: 4886
Slc22a2
Name: solute carrier family 22 (organic cation transporter), member 2
Synonyms: Oct2, Orct2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20518
VEGA: 17
Homologene: 68293
Vmn2r51
Name: vomeronasal 2, receptor 51
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042921
Homologene: 113703
Ly9
Name: lymphocyte antigen 9
Synonyms: T100, Lgp100, CD229, SLAMF3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17085
HGNC: HGNC:6730
Homologene: 1759
Ifi213
Name: interferon activated gene 213
Synonyms: E030037K03Rik, Pydc4, Pyr-A
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 623121
HGNC: HGNC:5395
Homologene: 115929
Or14c44
Name: olfactory receptor family 14 subfamily C member 44
Synonyms: GA_x6K02T2NHDJ-9693313-9692378, MOR221-1P, MOR211-8P, MOR221-4, MOR221-1P, Olfr1531-ps1, GA_x6K02T2NHDJ-9695951-9695766, Olfr302, Olfr301
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257958
Homologene: 128067
Klk1b16
Name: kallikrein 1-related peptidase b16
Synonyms: mGk-16, Klk16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16615
Homologene: 68141
Cxcl2
Name: C-X-C motif chemokine ligand 2
Synonyms: MIP-2, Mip2, Scyb, Scyb2, Mgsa-b, MIP-2a, CINC-2a, GROb, Gro2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20310
Homologene: 117695
Smim19
Name: small integral membrane protein 19
Synonyms: EST-c39, AI316807
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102032
Homologene: 26703
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to G, chromosome 1 at 55,019,395 bp
  • T to G, chromosome 1 at 75,360,586 bp
  • T to C, chromosome 1 at 87,915,480 bp
  • T to A, chromosome 1 at 97,098,498 bp
  • T to A, chromosome 1 at 121,461,983 bp
  • A to T, chromosome 1 at 136,282,094 bp
  • A to T, chromosome 1 at 171,280,006 bp
  • A to C, chromosome 1 at 171,596,558 bp
  • A to C, chromosome 1 at 173,567,218 bp
  • A to T, chromosome 1 at 193,178,291 bp
  • G to T, chromosome 2 at 25,577,031 bp
  • A to G, chromosome 2 at 36,688,758 bp
  • C to T, chromosome 2 at 76,900,961 bp
  • A to G, chromosome 2 at 79,315,688 bp
  • T to A, chromosome 2 at 97,630,772 bp
  • C to A, chromosome 3 at 36,570,730 bp
  • G to T, chromosome 3 at 87,994,212 bp
  • G to A, chromosome 3 at 95,735,963 bp
  • T to C, chromosome 3 at 104,046,853 bp
  • T to A, chromosome 3 at 135,270,900 bp
  • A to G, chromosome 4 at 115,433,984 bp
  • A to G, chromosome 4 at 123,241,399 bp
  • A to G, chromosome 4 at 125,707,997 bp
  • T to A, chromosome 5 at 16,572,477 bp
  • G to T, chromosome 5 at 33,657,756 bp
  • A to G, chromosome 5 at 35,703,349 bp
  • A to G, chromosome 5 at 90,904,012 bp
  • A to G, chromosome 6 at 18,225,937 bp
  • G to T, chromosome 6 at 67,356,592 bp
  • A to T, chromosome 6 at 122,315,074 bp
  • T to A, chromosome 6 at 132,208,544 bp
  • G to T, chromosome 6 at 141,459,098 bp
  • C to T, chromosome 7 at 10,102,445 bp
  • A to G, chromosome 7 at 10,102,446 bp
  • T to C, chromosome 7 at 44,141,001 bp
  • T to G, chromosome 7 at 44,513,687 bp
  • T to A, chromosome 7 at 44,839,387 bp
  • T to C, chromosome 7 at 79,433,193 bp
  • T to C, chromosome 7 at 86,412,367 bp
  • A to T, chromosome 7 at 103,552,165 bp
  • G to T, chromosome 8 at 11,530,430 bp
  • T to C, chromosome 8 at 22,463,336 bp
  • G to C, chromosome 8 at 71,397,780 bp
  • C to T, chromosome 8 at 75,099,949 bp
  • T to C, chromosome 9 at 39,060,141 bp
  • T to C, chromosome 9 at 111,469,208 bp
  • T to A, chromosome 10 at 33,909,731 bp
  • A to G, chromosome 10 at 57,807,492 bp
  • A to T, chromosome 10 at 60,419,699 bp
  • T to A, chromosome 11 at 9,399,180 bp
  • T to A, chromosome 11 at 60,370,766 bp
  • T to C, chromosome 11 at 82,917,846 bp
  • T to A, chromosome 11 at 98,912,211 bp
  • A to G, chromosome 12 at 65,093,689 bp
  • A to T, chromosome 13 at 54,052,945 bp
  • T to C, chromosome 13 at 67,317,063 bp
  • G to C, chromosome 13 at 73,267,841 bp
  • T to A, chromosome 16 at 34,010,548 bp
  • T to C, chromosome 17 at 12,584,411 bp
  • A to G, chromosome 17 at 35,666,258 bp
  • A to G, chromosome 17 at 49,496,120 bp
  • T to A, chromosome 17 at 74,692,237 bp
  • C to A, chromosome 18 at 43,243,084 bp
  • G to A, chromosome 18 at 77,211,764 bp
  • T to A, chromosome 19 at 4,619,086 bp
  • T to C, chromosome 19 at 10,481,406 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1559 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039598-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.