Strain Name:
C57BL/6J-MtgxR1580Btlr/Mmmh
Stock Number:
039617-MU
Citation ID:
RRID:MMRRC_039617-MU
Other Names:
R1580 (G1), C57BL/6J-MtgxR1580Btlr
Major Collection:

Gene Information

Abca12
Name: ATP-binding cassette, sub-family A (ABC1), member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 74591
Homologene: 45441
Mbtps1
Name: membrane-bound transcription factor peptidase, site 1
Synonyms: 0610038M03Rik, site-1 protease, SKI-1, S1P, subtilisin/kexin isozyme-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 56453
Homologene: 2808
B3galnt1
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
Synonyms: B3galt3, Globoside blood group, Brainiac 1, Mbrn 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 26879
HGNC: HGNC:918
Homologene: 32457
Igf1r
Name: insulin-like growth factor I receptor
Synonyms: A330103N21Rik, hyft, line 186, CD221, IGF-1R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16001
HGNC: HGNC:5465
Homologene: 30997
Bcl2l13
Name: BCL2-like 13 (apoptosis facilitator)
Synonyms: E430016C20Rik, BCL-RAMBO, Mil1, Mil-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 94044
Homologene: 9111
Kif15
Name: kinesin family member 15
Synonyms: 3110023M17Rik, HKLP2, 3930402I10Rik, N-10 kinesin, Knsl7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 209737
VEGA: 9
Homologene: 23210
Nup214
Name: nucleoporin 214
Synonyms: CAN, D2H9S46E
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Clec16a
Name: C-type lectin domain family 16, member A
Synonyms: curt, 4932416N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74374
Homologene: 71019
Rtf2
Name: replication termination factor 2
Synonyms: 1700067C04Rik, Rtfdc1, 2410001C21Rik, 5730427M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 66404
Homologene: 9501
Brms1l
Name: breast cancer metastasis-suppressor 1-like
Synonyms: 0710008O11Rik, D12Ertd407e, BRMS1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 52592
VEGA: 12
Homologene: 9123
Rfwd3
Name: ring finger and WD repeat domain 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234736
Homologene: 41230
Lins1
Name: lines homolog 1
Synonyms: Lins, Wins2, 2700083B01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 72635
Homologene: 10034
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 5730470G24Rik, CCCAP, 2700048G21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 76816
Homologene: 4839
Chst9
Name: carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
Synonyms: GalNAc4ST-2, 5430438D01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 71367
Homologene: 12861
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 94109
Homologene: 69536
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: B330005D23Rik, FOG2, FOG-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Zfp580
Name: zinc finger protein 580
Synonyms: 1500015O20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 68992
Homologene: 82467
Gm7361
Name: predicted gene 7361
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 664837
Homologene: 69402
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Gpr98, VLGR1, Mgr1, Mass1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 110789
Homologene: 19815
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 69047
Homologene: 73463
Olfr800
Name: olfactory receptor 800
Synonyms: GA_x6K02T2PULF-11338429-11339364, MOR114-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 258541
Homologene: 27203
Vmn2r10
Name: vomeronasal 2, receptor 10
Synonyms: VR16, V2r16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22307
Homologene: 129606
Arhgef38
Name: Rho guanine nucleotide exchange factor (GEF) 38
Synonyms: D630013G24Rik, 9130221D24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 77669
Homologene: 137396
Mest
Name: mesoderm specific transcript
Synonyms: Peg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 17294
HGNC: HGNC:7028
Homologene: 1800
Haus1
Name: HAUS augmin-like complex, subunit 1
Synonyms: HEI-C, spindle associated, Ccdc5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225745
VEGA: 18
Homologene: 15516
Atp6v0a1
Name: ATPase, H+ transporting, lysosomal V0 subunit A1
Synonyms: Vpp-1, Vpp1, V-ATPase a1, Atp6n1a, Atp6n1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11975
HGNC: HGNC:865
Homologene: 3795
Atp8b5
Name: ATPase, class I, type 8B, member 5
Synonyms: FetA, 4930417M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320571
Homologene: 99882
Emilin1
Name: elastin microfibril interfacer 1
Synonyms: EMILIN-1, 5830419M17Rik, gp115
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100952
Homologene: 5117
Cyp3a16
Name: cytochrome P450, family 3, subfamily a, polypeptide 16
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 13114
HGNC: HGNC:2638
Homologene: 133568
Vmn2r45
Name: vomeronasal 2, receptor 45
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042810
Homologene: 113703
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: D7Ucla4, testosterone 15alpha-hydroxylase, Cyp15a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13086
Homologene: 85917
Fam205c
Name: family with sequence similarity 205, member C
Synonyms: BC049635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 277773
Homologene: 77625
Klk10
Name: kallikrein related-peptidase 10
Synonyms: 2300002A13Rik, NES1, PRSSL1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 69540
HGNC: HGNC:6358
Homologene: 26428
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Trabd2b
Name: TraB domain containing 2B
Synonyms: Hkat, Gm12824
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 666048
Homologene: 85034
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: Cmar, spastic paraplegia 7 homolog (human), paraplegin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234847
Homologene: 31133
Ccdc82
Name: coiled-coil domain containing 82
Synonyms: 2310043N13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 66396
VEGA: 9
Homologene: 11678
Olfr299
Name: olfactory receptor 299
Synonyms: GA_x6K02T2NHDJ-9643949-9642957, MOR221-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 257929
Homologene: 115489
Clec5a
Name: C-type lectin domain family 5, member a
Synonyms: myeloid DAP12-associating lectin-1, MDL-1, Ly100, Clecsf5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 23845
HGNC: HGNC:2054
Homologene: 8302
Sbspon
Name: somatomedin B and thrombospondin, type 1 domain containing
Synonyms: LOC226866, Gm106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226866
Homologene: 45950
Dok2
Name: docking protein 2
Synonyms: Frip, Frip, DokR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13449
HGNC: HGNC:2991
Homologene: 2957
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 15,892,468 bp
  • C to T, chromosome 1 at 71,265,965 bp
  • T to C, chromosome 1 at 176,919,534 bp
  • C to T, chromosome 2 at 32,034,466 bp
  • A to G, chromosome 2 at 172,445,365 bp
  • A to G, chromosome 3 at 69,575,707 bp
  • T to C, chromosome 3 at 133,133,704 bp
  • T to C, chromosome 4 at 42,874,020 bp
  • T to C, chromosome 4 at 43,355,673 bp
  • T to C, chromosome 4 at 114,580,334 bp
  • G to T, chromosome 5 at 26,257,770 bp
  • A to G, chromosome 5 at 30,917,420 bp
  • A to T, chromosome 5 at 109,006,251 bp
  • T to A, chromosome 5 at 145,442,074 bp
  • T to C, chromosome 5 at 145,442,075 bp
  • G to A, chromosome 6 at 30,745,823 bp
  • G to T, chromosome 6 at 40,585,219 bp
  • G to A, chromosome 6 at 104,835,864 bp
  • A to G, chromosome 6 at 120,865,714 bp
  • C to T, chromosome 7 at 5,053,285 bp
  • T to G, chromosome 7 at 8,471,747 bp
  • T to C, chromosome 7 at 26,307,651 bp
  • C to T, chromosome 7 at 43,782,862 bp
  • C to A, chromosome 7 at 66,714,491 bp
  • T to C, chromosome 7 at 68,207,869 bp
  • A to G, chromosome 7 at 86,465,450 bp
  • T to A, chromosome 8 at 15,925,299 bp
  • C to T, chromosome 8 at 111,288,242 bp
  • C to T, chromosome 8 at 119,538,900 bp
  • A to G, chromosome 8 at 119,752,987 bp
  • T to A, chromosome 8 at 123,090,238 bp
  • C to T, chromosome 9 at 13,252,760 bp
  • T to C, chromosome 9 at 122,959,956 bp
  • G to T, chromosome 10 at 129,660,315 bp
  • T to C, chromosome 11 at 101,029,204 bp
  • A to T, chromosome 12 at 55,868,222 bp
  • A to G, chromosome 13 at 81,466,160 bp
  • A to G, chromosome 14 at 70,776,957 bp
  • A to G, chromosome 15 at 41,103,209 bp
  • A to G, chromosome 16 at 10,595,898 bp
  • T to G, chromosome 18 at 15,453,065 bp
  • T to C, chromosome 18 at 77,766,920 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1580 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039617-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.