Strain Name:
C57BL/6J-MtgxR1592Btlr/Mmmh
Stock Number:
039629-MU
Citation ID:
RRID:MMRRC_039629-MU
Other Names:
R1592 (G1), C57BL/6J-MtgxR1592Btlr
Major Collection:

Gene Information

Gli1
Name: GLI-Kruppel family member GLI1
Synonyms: Zfp-5, Zfp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 14632
VEGA: 10
HGNC: HGNC:4317
Homologene: 3859
Inpp5d
Name: inositol polyphosphate-5-phosphatase D
Synonyms: SHIP, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP, SHIP-1, SHIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16331
HGNC: HGNC:6079
Homologene: 4046
Mga
Name: MAX gene associated
Synonyms: Mga, Mad5, C130042M01Rik, D030062C11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 29808
Homologene: 49351
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Eca39, BCATc, Bcat-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Msh2
Name: mutS homolog 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 17685
HGNC: HGNC:7325
Homologene: 210
Cc2d1b
Name: coiled-coil and C2 domain containing 1B
Synonyms: A830039B04Rik, Freud2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 319965
Homologene: 70951
Tdrd3
Name: tudor domain containing 3
Synonyms: 4732418C03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 219249
Homologene: 12771
Ccnk
Name: cyclin K
Synonyms: CPR4, CycK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 12454
VEGA: 12
HGNC: HGNC:1596
Homologene: 14748
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: Sp6, Phxr3, mbo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 99526
Homologene: 34521
Ccdc141
Name: coiled-coil domain containing 141
Synonyms: ENSMUSG00000075261, CAMDI, 2610301F02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 545428
Homologene: 52149
Wdfy1
Name: WD repeat and FYVE domain containing 1
Synonyms: 1700013B03Rik, Jr1, 1700120F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 69368
Homologene: 10825
Acp5
Name: acid phosphatase 5, tartrate resistant
Synonyms: TRAP, TRACP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 11433
VEGA: 9
HGNC: HGNC:124
Homologene: 137203
Kcnj3
Name: potassium inwardly-rectifying channel, subfamily J, member 3
Synonyms: Kir3.1, GIRK1, Kcnf3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 16519
HGNC: HGNC:6264
Homologene: 1687
Fbln1
Name: fibulin 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 14114
HGNC: HGNC:3600
Homologene: 21295
Kirrel
Name: kirre like nephrin family adhesion molecule 1
Synonyms: Neph1, Kirrel1, 6720469N11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 170643
Homologene: 10089
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, C820010P03Rik, 0910001L17Rik, Ugcgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 320011
Homologene: 10586
H2-T22
Name: histocompatibility 2, T region locus 22
Synonyms: H-2T22, H-2T17, H2-T17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 15039
Homologene: 79525
Pitpnm1
Name: phosphatidylinositol transfer protein, membrane-associated 1
Synonyms: DRES9, RdgB
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 18739
HGNC: HGNC:9003
Homologene: 3608
Tcaim
Name: T cell activation inhibitor, mitochondrial
Synonyms: LOC382117, D9Ertd402e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 382117
Homologene: 45481
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26875
Homologene: 69111
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 71985
Homologene: 49825
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Ipcef1
Name: interaction protein for cytohesin exchange factors 1
Synonyms: A130090K04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 320495
Homologene: 32271
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 70885
Homologene: 10029
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 329628
Homologene: 14377
Nckap1l
Name: NCK associated protein 1 like
Synonyms: 4930568P13Rik, Hem1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Ephb3
Name: Eph receptor B3
Synonyms: Sek4, MDK5, HEK2, Etk2, Tyro6, Cek10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 13845
HGNC: HGNC:3394
Homologene: 20938
Krt73
Name: keratin 73
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223915
Homologene: 27875
Aox2
Name: aldehyde oxidase 2
Synonyms: Aox3l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 213043
Homologene: 84622
Psma1
Name: proteasome subunit alpha 1
Synonyms: C2, Pros-30, HC2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 26440
HGNC: HGNC:9530
Homologene: 2080
Sik2
Name: salt inducible kinase 2
Synonyms: G630080D20Rik, Snf1lk2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235344
Homologene: 22875
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 72277
Spty2d1
Name: SPT2 chromatin protein domain containing 1
Synonyms: 5830435K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 101685
Homologene: 45499
Slc26a7
Name: solute carrier family 26, member 7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 208890
Homologene: 13770
Cdh26
Name: cadherin-like 26
Synonyms: LOC381409
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 381409
Homologene: 18643
Klf11
Name: Kruppel-like factor 11
Synonyms: Tieg2b, D12Ertd427e, Tieg2, Tieg3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 194655
Homologene: 2668
Atg16l2
Name: autophagy related 16-like 2 (S. cerevisiae)
Synonyms: 2410118P20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 73683
Homologene: 18981
Alkbh3
Name: alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
Synonyms: 1700108H04Rik, 1810020C19Rik, Abh3, mABH3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 69113
Homologene: 16393
Mfrp
Name: membrane frizzled-related protein
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 259172
Homologene: 12866
Or5m9
Name: olfactory receptor family 5 subfamily M member 9
Synonyms: MOR227-8P, GA_x6K02T2Q125-47521463-47522395, MOR227-8P, MOR245-14P, Olfr1533-ps1, Olfr1034
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258216
Homologene: 51741
Adamts8
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
Synonyms: METH2, METH-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 30806
HGNC: HGNC:224
Homologene: 5108
Ankrd13d
Name: ankyrin repeat domain 13 family, member D
Synonyms: 0710001P18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 68423
Homologene: 27612
Aspg
Name: asparaginase
Synonyms: A530050D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 104816
VEGA: 12
Homologene: 113390
Mapk10
Name: mitogen-activated protein kinase 10
Synonyms: p493F12, JNK3, Serk2, C230008H04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 26414
HGNC: HGNC:6872
Homologene: 56439
Cnbd2
Name: cyclic nucleotide binding domain containing 2
Synonyms: 5430421B09Rik, 4921517L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 70873
Homologene: 15440
Rpl31-ps20
Name: ribosomal protein L31, pseudogene 20
Synonyms: Gm6635
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 625917
Zfp995
Name: zinc finger protein 995
Synonyms: 2210404O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 70081
Homologene: 133253
Vmn1r223
Name: vomeronasal 1 receptor 223
Synonyms: Gm11330
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 100036518
Homologene: 110880
Lactbl1
Name: lactamase, beta-like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 242707
Homologene: 82492
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 36,202,858 bp
  • A to G, chromosome 1 at 58,300,694 bp
  • G to A, chromosome 1 at 79,706,255 bp
  • A to T, chromosome 1 at 87,665,532 bp
  • G to T, chromosome 2 at 55,437,886 bp
  • A to G, chromosome 2 at 77,128,350 bp
  • A to G, chromosome 2 at 86,046,989 bp
  • A to C, chromosome 2 at 94,008,424 bp
  • A to T, chromosome 2 at 119,964,666 bp
  • A to G, chromosome 2 at 156,335,402 bp
  • T to C, chromosome 2 at 178,449,891 bp
  • A to T, chromosome 3 at 39,007,177 bp
  • G to T, chromosome 3 at 87,097,915 bp
  • A to T, chromosome 3 at 122,934,050 bp
  • T to A, chromosome 4 at 14,552,470 bp
  • C to T, chromosome 4 at 108,626,671 bp
  • A to G, chromosome 4 at 136,635,876 bp
  • T to C, chromosome 5 at 14,723,336 bp
  • T to C, chromosome 5 at 103,038,621 bp
  • T to C, chromosome 5 at 121,645,381 bp
  • G to T, chromosome 6 at 145,010,058 bp
  • A to T, chromosome 7 at 46,998,889 bp
  • C to A, chromosome 7 at 101,291,986 bp
  • A to G, chromosome 7 at 114,273,929 bp
  • A to G, chromosome 8 at 68,802,903 bp
  • A to T, chromosome 9 at 22,127,851 bp
  • T to C, chromosome 9 at 30,943,176 bp
  • G to A, chromosome 9 at 44,103,222 bp
  • C to T, chromosome 9 at 50,995,671 bp
  • G to A, chromosome 9 at 122,818,773 bp
  • C to T, chromosome 10 at 6,935,182 bp
  • A to C, chromosome 10 at 127,331,329 bp
  • T to C, chromosome 11 at 55,291,870 bp
  • C to A, chromosome 12 at 24,653,738 bp
  • A to G, chromosome 12 at 108,194,328 bp
  • G to A, chromosome 12 at 112,119,972 bp
  • A to T, chromosome 13 at 23,249,667 bp
  • T to A, chromosome 14 at 87,505,886 bp
  • T to A, chromosome 15 at 85,231,464 bp
  • T to C, chromosome 15 at 99,940,318 bp
  • G to T, chromosome 15 at 101,802,239 bp
  • T to A, chromosome 15 at 103,482,180 bp
  • T to C, chromosome 16 at 21,221,700 bp
  • T to A, chromosome 17 at 21,887,340 bp
  • T to C, chromosome 17 at 36,041,577 bp
  • A to G, chromosome 17 at 87,680,013 bp
  • T to A, chromosome 19 at 4,106,964 bp
  • T to C, chromosome 19 at 4,282,891 bp
  • G to A, chromosome 19 at 30,160,677 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1592 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039629-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.