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Strain Name:
C57BL/6J-MtgxR1606Btlr/Mmmh
Stock Number:
039643-MU
Citation ID:
RRID:MMRRC_039643-MU
Other Names:
R1606 (G1), C57BL/6J-MtgxR1606Btlr
Major Collection:

Strain Information

Tyr
Name: tyrosinase
Synonyms: skc35, Oca1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22173
Homologene: 30969
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: A330076K04Rik, 1100001C18Rik, 2500002E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Ppp1r37
Name: protein phosphatase 1, regulatory subunit 37
Synonyms: Lrrc68
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232947
Homologene: 17851
Adsl
Name: adenylosuccinate lyase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11564
HGNC: HGNC:291
Homologene: 12
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 9,553,473 bp
  • G to T, chromosome 1 at 184,731,987 bp
  • A to G, chromosome 1 at 188,759,766 bp
  • A to T, chromosome 2 at 6,195,627 bp
  • A to T, chromosome 2 at 11,595,397 bp
  • A to G, chromosome 2 at 37,429,118 bp
  • A to T, chromosome 2 at 52,287,036 bp
  • C to T, chromosome 2 at 76,737,012 bp
  • A to T, chromosome 2 at 120,750,458 bp
  • C to T, chromosome 2 at 151,654,686 bp
  • A to G, chromosome 2 at 153,400,455 bp
  • G to A, chromosome 3 at 36,942,399 bp
  • A to T, chromosome 3 at 53,458,657 bp
  • A to C, chromosome 3 at 82,864,541 bp
  • A to G, chromosome 3 at 104,480,107 bp
  • A to T, chromosome 3 at 153,206,668 bp
  • G to A, chromosome 4 at 94,849,767 bp
  • T to C, chromosome 4 at 107,102,513 bp
  • A to T, chromosome 4 at 112,389,201 bp
  • A to T, chromosome 4 at 132,334,776 bp
  • T to C, chromosome 4 at 133,260,847 bp
  • C to A, chromosome 5 at 4,757,514 bp
  • A to T, chromosome 5 at 41,698,452 bp
  • T to C, chromosome 5 at 150,059,897 bp
  • T to A, chromosome 6 at 34,158,388 bp
  • T to A, chromosome 6 at 127,689,836 bp
  • G to T, chromosome 6 at 141,839,611 bp
  • T to A, chromosome 6 at 148,355,345 bp
  • A to G, chromosome 7 at 4,472,212 bp
  • A to T, chromosome 7 at 5,035,775 bp
  • A to T, chromosome 7 at 19,534,999 bp
  • T to A, chromosome 7 at 25,358,695 bp
  • A to G, chromosome 7 at 25,388,144 bp
  • A to T, chromosome 7 at 87,437,971 bp
  • T to C, chromosome 7 at 106,602,445 bp
  • T to A, chromosome 7 at 143,085,171 bp
  • A to G, chromosome 8 at 36,850,252 bp
  • A to G, chromosome 8 at 61,124,276 bp
  • C to A, chromosome 8 at 83,295,304 bp
  • T to G, chromosome 9 at 20,212,946 bp
  • A to G, chromosome 9 at 24,581,215 bp
  • A to G, chromosome 9 at 36,719,524 bp
  • A to C, chromosome 9 at 53,374,295 bp
  • A to T, chromosome 9 at 99,537,729 bp
  • G to T, chromosome 9 at 103,225,136 bp
  • A to G, chromosome 9 at 106,681,853 bp
  • T to C, chromosome 10 at 8,729,957 bp
  • G to T, chromosome 10 at 31,534,811 bp
  • C to T, chromosome 10 at 58,269,448 bp
  • T to C, chromosome 10 at 62,822,775 bp
  • T to C, chromosome 10 at 80,532,578 bp
  • T to C, chromosome 10 at 117,217,439 bp
  • C to A, chromosome 11 at 5,064,434 bp
  • T to A, chromosome 11 at 40,736,007 bp
  • C to T, chromosome 11 at 72,437,733 bp
  • C to T, chromosome 11 at 75,906,541 bp
  • T to A, chromosome 12 at 78,683,883 bp
  • T to C, chromosome 12 at 83,801,010 bp
  • C to T, chromosome 12 at 101,765,198 bp
  • A to T, chromosome 14 at 35,445,965 bp
  • T to A, chromosome 14 at 77,029,641 bp
  • C to T, chromosome 15 at 80,952,224 bp
  • T to C, chromosome 16 at 95,361,331 bp
  • G to A, chromosome 17 at 10,839,838 bp
  • T to A, chromosome 17 at 15,401,811 bp
  • T to A, chromosome 17 at 28,638,481 bp
  • T to C, chromosome 17 at 31,213,924 bp
  • T to A, chromosome 18 at 21,565,532 bp
  • T to A, chromosome 18 at 39,296,872 bp
  • A to G, chromosome 18 at 68,311,653 bp
  • A to C, chromosome 18 at 84,962,620 bp
  • G to T, chromosome 19 at 4,750,242 bp
  • A to T, chromosome 19 at 5,287,998 bp
  • C to T, chromosome 19 at 34,594,044 bp
  • T to G, chromosome 19 at 41,585,074 bp
  • A to G, chromosome 19 at 43,836,652 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1606 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039643-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.