Strain Name:
C57BL/6J-MtgxR1609Btlr/Mmmh
Stock Number:
039646-MU
Citation ID:
RRID:MMRRC_039646-MU
Other Names:
R1609 (G1), C57BL/6J-MtgxR1609Btlr
Major Collection:

Gene Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 66797
Homologene: 69159
App
Name: amyloid beta (A4) precursor protein
Synonyms: Cvap, E030013M08Rik, appican, betaAPP, protease nexin II, Abeta, Adap
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Med1
Name: mediator complex subunit 1
Synonyms: CRSP210, TRAP220, TRAP 220, l11Jus15, Pparbp, DRIP205, PBP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: 9030612K14Rik, Prkm1, p42mapk, Erk2, MAPK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: Dhm2, mXrn1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 24127
Homologene: 5894
Gnaq
Name: guanine nucleotide binding protein, alpha q polypeptide
Synonyms: Galphaq, 6230401I02Rik, Gq, 1110005L02Rik, GqI, G alpha q, Dsk10, Dsk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 14682
HGNC: HGNC:4390
Homologene: 1566
Atpif1
Name: ATPase inhibitory factor 1
Synonyms: If1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 11983
HGNC: HGNC:871
Homologene: 40581
Ccdc6
Name: coiled-coil domain containing 6
Synonyms: 2810012H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 76551
Homologene: 34786
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Anxa2
Name: annexin A2
Synonyms: 36-kDa calelectrin, annexin II, Cal1h, lipocortin II
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12306
HGNC: HGNC:537
Homologene: 20857
Vdac2
Name: voltage-dependent anion channel 2
Synonyms: Vdac6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 22334
Homologene: 37765
Zfp277
Name: zinc finger protein 277
Synonyms: NIRF4, 2410017E24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 246196
VEGA: 12
Homologene: 11087
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 50767
Homologene: 21333
Snx9
Name: sorting nexin 9
Synonyms: SH3PX1, SDP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 66616
VEGA: 17
Homologene: 49454
Pnisr
Name: PNN interacting serine/arginine-rich
Synonyms: 5730406M06Rik, Sfrs18
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 66625
Homologene: 32802
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Kif24
Name: kinesin family member 24
Synonyms: 4933425J19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 109242
Homologene: 52346
Taf4b
Name: TATA-box binding protein associated factor 4b
Synonyms: 4932409F03Rik, 2610524B04Rik, TAFII105, 105kDa, Taf2c2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 72504
VEGA: 18
Homologene: 28266
Sf3b2
Name: splicing factor 3b, subunit 2
Synonyms: B230398H18Rik, SF3b145, SF3b150, SF3b1, SAP145, 2610311M13Rik, 145kDa, 2810441F20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 319322
VEGA: 19
Homologene: 6678
Myo6
Name: myosin VI
Synonyms: Tlc, rsv, Myo6rsv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: Gm980, A230079K17Rik, Dnahc14, LOC381311
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Sycp1
Name: synaptonemal complex protein 1
Synonyms: SCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20957
Homologene: 2389
Setmar
Name: SET domain without mariner transposase fusion
Synonyms: Etet2, 5830404F24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 74729
Homologene: 68519
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Rp1h, oxygen-regulated protein 1, mG145, Orp1, Dcdc3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19888
Homologene: 4564
Ly75
Name: lymphocyte antigen 75
Synonyms: DEC-205, CD205
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 17076
HGNC: HGNC:6729
Homologene: 31085
Olfr1080
Name: olfactory receptor 1080
Synonyms: GA_x6K02T2Q125-48039418-48038477, MOR192-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258404
Homologene: 104285
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Sema3d
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Synonyms: 4631426B19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 108151
Homologene: 23664
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241263
Homologene: 19381
Vmn1r22
Name: vomeronasal 1 receptor 22
Synonyms: V1rc23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171196
Homologene: 110825
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: Dnahc7b, LOC227058
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227058
Homologene: 41287
CT025661.1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 68655
Pgbd5
Name: piggyBac transposable element derived 5
Synonyms: 2900019M05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 209966
Homologene: 11583
Olfr1218
Name: olfactory receptor 1218
Synonyms: MOR233-12, GA_x6K02T2Q125-50536041-50535106
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258815
Homologene: 73986
Rtp3
Name: receptor transporter protein 3
Synonyms: Tmem7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235636
Homologene: 135957
Olfr1058
Name: olfactory receptor 1058
Synonyms: MOR190-2, GA_x6K02T2Q125-47855818-47854868
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258386
Homologene: 74093
Acot2
Name: acyl-CoA thioesterase 2
Synonyms: Mte1, MTE-I
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 171210
Homologene: 25661
Cntn6
Name: contactin 6
Synonyms: NB-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 53870
HGNC: HGNC:2176
Homologene: 8702
Cbr4
Name: carbonyl reductase 4
Synonyms: A730083J17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 234309
Homologene: 57181
Tktl2
Name: transketolase-like 2
Synonyms: 4933401I19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 74419
Homologene: 69456
Ccdc173
Name: coiled-coil domain containing 173
Synonyms: 4930578N16Rik, 4930525K21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 75051
Homologene: 18989
4932415M13Rik
Name: RIKEN cDNA 4932415M13 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 211496
Allc
Name: allantoicase
Synonyms: 1700012B22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 94041
Homologene: 6202
Prkra
Name: protein kinase, interferon inducible double stranded RNA dependent activator
Synonyms: PRK, RAX, lear, Pact
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 23992
HGNC: HGNC:9438
Homologene: 2738
Vmn2r31
Name: vomeronasal 2, receptor 31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 100042591
Homologene: 113703
Tspan4
Name: tetraspanin 4
Synonyms: novel antigen 2, NAG-2, Tm4sf7, Tspan-4, D130042I01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 64540
Homologene: 2453
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,349,201 bp
  • T to C, chromosome 1 at 46,352,966 bp
  • T to C, chromosome 1 at 181,750,177 bp
  • A to G, chromosome 2 at 21,783,293 bp
  • A to T, chromosome 2 at 60,321,685 bp
  • G to A, chromosome 2 at 69,758,472 bp
  • A to T, chromosome 2 at 76,633,592 bp
  • A to G, chromosome 2 at 86,385,494 bp
  • A to C, chromosome 2 at 86,553,605 bp
  • A to T, chromosome 2 at 89,055,344 bp
  • A to T, chromosome 3 at 102,845,102 bp
  • G to T, chromosome 4 at 21,871,440 bp
  • A to T, chromosome 4 at 41,397,534 bp
  • T to C, chromosome 4 at 132,530,767 bp
  • A to G, chromosome 5 at 12,541,056 bp
  • T to C, chromosome 6 at 46,015,330 bp
  • G to T, chromosome 6 at 57,900,748 bp
  • G to A, chromosome 6 at 104,835,864 bp
  • A to G, chromosome 6 at 108,076,115 bp
  • T to C, chromosome 7 at 7,384,889 bp
  • A to G, chromosome 7 at 141,491,644 bp
  • T to C, chromosome 8 at 3,517,135 bp
  • T to A, chromosome 8 at 61,503,158 bp
  • A to G, chromosome 8 at 66,512,852 bp
  • T to C, chromosome 8 at 124,434,011 bp
  • A to G, chromosome 9 at 54,409,263 bp
  • TCCC to TCC, chromosome 9 at 69,489,754 bp
  • G to A, chromosome 9 at 80,288,217 bp
  • A to T, chromosome 9 at 95,974,893 bp
  • C to T, chromosome 9 at 109,663,510 bp
  • A to G, chromosome 9 at 110,986,017 bp
  • C to A, chromosome 10 at 70,167,047 bp
  • T to A, chromosome 11 at 98,161,170 bp
  • A to T, chromosome 12 at 28,553,994 bp
  • A to T, chromosome 12 at 40,328,720 bp
  • C to T, chromosome 12 at 83,992,856 bp
  • G to A, chromosome 13 at 52,835,496 bp
  • T to C, chromosome 14 at 21,833,859 bp
  • A to G, chromosome 15 at 8,366,664 bp
  • T to C, chromosome 16 at 17,038,306 bp
  • C to A, chromosome 16 at 85,079,949 bp
  • G to T, chromosome 17 at 5,902,523 bp
  • G to T, chromosome 17 at 7,772,766 bp
  • G to A, chromosome 17 at 53,724,292 bp
  • A to G, chromosome 18 at 14,835,881 bp
  • A to G, chromosome 19 at 5,295,033 bp
  • G to A, chromosome 19 at 16,383,254 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1609 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039646-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.