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Strain Name:
C57BL/6J-MtgxR1610Btlr/Mmmh
Stock Number:
039647-MU
Citation ID:
RRID:MMRRC_039647-MU
Other Names:
R1610 (G1), C57BL/6J-MtgxR1610Btlr
Major Collection:

Strain Information

Lrrn3
Name: leucine rich repeat protein 3, neuronal
Synonyms: NLRR-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16981
VEGA: 12
Homologene: 36315
Pik3cd
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
Synonyms: p110delta, 2410099E07Rik, 2610208K16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18707
HGNC: HGNC:8977
Homologene: 3686
Trdmt1
Name: tRNA aspartic acid methyltransferase 1
Synonyms: Rnmt2, Dnmt2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13434
HGNC: HGNC:2977
Homologene: 3249
Nup214
Name: nucleoporin 214
Synonyms: D2H9S46E, CAN
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227720
HGNC: HGNC:8064
Homologene: 38008
Tonsl
Name: tonsoku-like, DNA repair protein
Synonyms: 2810439M11Rik, Nfkbil2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72749
HGNC: HGNC:7801
Homologene: 22754
Cramp1
Name: cramped chromatin regulator 1
Synonyms: 5830477H08Rik, Tce4, Cramp1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57354
VEGA: 17
Homologene: 35373
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lec2, lectomedin-2, 2900070I05Rik, Lphn1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Rtn1
Name: reticulon 1
Synonyms: Nsp, Rtn1-b, Rtn1-c, 0710005K15Rik, Rtn1-a, 4930441F12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104001
Homologene: 49654
Mmp16
Name: matrix metallopeptidase 16
Synonyms: Membrane type 3-MMP, MT3-MMP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17389
HGNC: HGNC:7162
Homologene: 55939
Anxa2
Name: annexin A2
Synonyms: lipocortin II, 36-kDa calelectrin, Cal1h, annexin II
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12306
Homologene: 20857
Jph4
Name: junctophilin 4
Synonyms: JPHL1, JP-4, 9330157P13Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319984
Homologene: 13034
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Lhfpl4
Name: lipoma HMGIC fusion partner-like protein 4
Synonyms: 1190004M23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269788
Homologene: 14943
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, castor, Cst
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74241
Homologene: 11574
Rbpj-ps3
Name: recombination signal binding protein for immunoglobulin kappa J region, pseudogene 3
Synonyms: Igkrsbp-rs3, Rbpsuh-rs3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 19667
Pms1
Name: PMS1 homolog 1, mismatch repair system component
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227099
HGNC: HGNC:9121
Homologene: 449
Blnk
Name: B cell linker
Synonyms: SLP-65, BCA, BASH, BLNK, Ly-57, Bca, Ly57
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 17060
Homologene: 32038
Plagl1
Name: pleiomorphic adenoma gene-like 1
Synonyms: Zac1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22634
HGNC: HGNC:9046
Homologene: 31401
Lig1
Name: ligase I, DNA, ATP-dependent
Synonyms: mLigI, LigI
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16881
HGNC: HGNC:6598
Homologene: 197
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Fat2
Name: FAT atypical cadherin 2
Synonyms: LOC245827, mKIAA0811, Fath2, EMI2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: XT2, D630001K16Rik, Xtrp2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Dpyd
Name: dihydropyrimidine dehydrogenase
Synonyms: DPD, E330028L06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99586
HGNC: HGNC:3012
Homologene: 85
Ephb6
Name: Eph receptor B6
Synonyms: Mep, Cekl
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13848
HGNC: HGNC:3396
Homologene: 20940
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Serpina1a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms: PI1, Aat-2, Spi1-1, Aat2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20700
HGNC: HGNC:8941
Homologene: 20103
Golgb1
Name: golgin B1
Synonyms: Giantin, C130074L01Rik, F730017E11Rik, 6330407A06Rik, Gm6840
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224139
HGNC: HGNC:4429
Homologene: 68401
Klra8
Name: killer cell lectin-like receptor, subfamily A, member 8
Synonyms: Cmv-1, Ly49h, Cmv1, Ly49u129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16639
Homologene: 110821
Or8b1b
Name: olfactory receptor family 8 subfamily B member 1B
Synonyms: GA_x6K02T2PVTD-32156773-32157705, MOR167-3, Olfr904
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258797
VEGA: 9
Homologene: 133629
Lmbrd2
Name: LMBR1 domain containing 2
Synonyms: 9930036E21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320506
VEGA: 15
Homologene: 44696
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665227
Homologene: 129751
Megf6
Name: multiple EGF-like-domains 6
Synonyms: 2600001P17Rik, Egfl3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Nfatc2ip
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein
Synonyms: NIP45, D7Ertd304e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18020
Homologene: 7862
C2
Name: complement C2
Synonyms: classical-complement pathway C3/C5 convertase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12263
HGNC: HGNC:1248
Homologene: 45
Cfap20dc
Name: CFAP20 domain containing
Synonyms: 4930452B06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 74430
Homologene: 18873
Dixdc1
Name: DIX domain containing 1
Synonyms: 4930563F16Rik, Ccd1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330938
Homologene: 82369
Isg20
Name: interferon-stimulated protein
Synonyms: DnaQl, HEM45, 2010107M23Rik, 1600023I01Rik, 20kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57444
HGNC: HGNC:6130
Homologene: 31081
Mc2r
Name: melanocortin 2 receptor
Synonyms: adrenocorticotropic hormone receptor, Acthr
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17200
VEGA: 18
HGNC: HGNC:6930
Homologene: 444
Agbl4
Name: ATP/GTP binding protein-like 4
Synonyms: 4930578N11Rik, 4931433A01Rik, Ccp6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 78933
Homologene: 84880
Nup50l
Name: nucleoporin 50 like
Synonyms: 1700123L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78482
HGNC: HGNC:8065
Cobll1
Name: Cobl-like 1
Synonyms: Coblr1, D430044D16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319876
Homologene: 8933
Far2
Name: fatty acyl CoA reductase 2
Synonyms: Mlstd1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330450
Homologene: 69247
Or4s2b
Name: olfactory receptor family 4 subfamily S member 2B
Synonyms: GA_x6K02T2Q125-50158288-50158818, GA_x6K02T2Q125-50154044-50154826, MOR230-9, MOR226-1, Olfr1194-ps1, Olfr1193
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329460
Homologene: 27297
Tchh
Name: trichohyalin
Synonyms: Thh, AHF
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99681
Homologene: 136273
Kcnq3
Name: potassium voltage-gated channel, subfamily Q, member 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110862
HGNC: HGNC:6297
Homologene: 20949
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Ldlrad1
Name: low density lipoprotein receptor class A domain containing 1
Synonyms: OTTMUSG00000008594
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 546840
Homologene: 54473
Ptpn22
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Synonyms: 70zpep, Ptpn8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19260
HGNC: HGNC:9652
Homologene: 7498
Ubash3b
Name: ubiquitin associated and SH3 domain containing, B
Synonyms: 2810457I06Rik, TULA-2, Sts-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72828
Homologene: 13152
Zfp474
Name: zinc finger protein 474
Synonyms: 4933409D10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66758
Homologene: 12027
Selenoo
Name: selenoprotein O
Synonyms: 1300018J18Rik, Selo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223776
Homologene: 69439
Kcnq5
Name: potassium voltage-gated channel, subfamily Q, member 5
Synonyms: 9230107O05Rik, D1Mgi1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226922
HGNC: HGNC:6299
Homologene: 28270
Pla2g4d
Name: phospholipase A2, group IVD
Synonyms: 2610311B01Rik, Pla2delta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78390
Homologene: 52252
AC139244.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Or10a48
Name: olfactory receptor family 10 subfamily A member 48
Synonyms: GA_x6K02T2PBJ9-11156311-11155379, MOR268-1, Olfr514
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258721
Homologene: 73956
Pacc1
Name: proton activated chloride channel 1
Synonyms: 2310028N02Rik, Tmem206
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66950
Homologene: 10097
Or4c15b
Name: olfactory receptor family 4 subfamily C member 15B
Synonyms: GA_x6K02T2Q125-50727797-50726862, MOR233-22, MOR233-19, Olfr1229
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257921
Homologene: 79376
Frg2f1
Name: FSHD region gene 2 family member 1
Synonyms: AA415398
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433752
Homologene: 86332
Scgb2b3
Name: secretoglobin, family 2B, member 3
Synonyms: Gm4362, Abpbg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043326
Homologene: 83171
Cldn23
Name: claudin 23
Synonyms: 2310014B08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71908
Homologene: 12421
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 21,457,461 bp
  • A to T, chromosome 1 at 53,216,357 bp
  • A to G, chromosome 1 at 75,476,648 bp
  • A to G, chromosome 1 at 191,345,065 bp
  • G to A, chromosome 2 at 13,516,059 bp
  • G to A, chromosome 2 at 23,090,551 bp
  • A to T, chromosome 2 at 30,173,887 bp
  • C to T, chromosome 2 at 32,034,466 bp
  • G to T, chromosome 2 at 35,006,161 bp
  • C to T, chromosome 2 at 65,133,642 bp
  • A to T, chromosome 2 at 88,678,574 bp
  • T to C, chromosome 2 at 89,282,821 bp
  • G to A, chromosome 2 at 120,288,955 bp
  • A to T, chromosome 2 at 181,996,179 bp
  • C to T, chromosome 3 at 93,444,839 bp
  • G to A, chromosome 3 at 103,902,196 bp
  • A to G, chromosome 3 at 119,065,006 bp
  • A to G, chromosome 4 at 18,011,582 bp
  • A to G, chromosome 4 at 107,214,875 bp
  • G to A, chromosome 4 at 111,657,168 bp
  • T to A, chromosome 4 at 119,531,288 bp
  • C to T, chromosome 4 at 148,929,087 bp
  • T to C, chromosome 4 at 149,659,997 bp
  • T to C, chromosome 4 at 154,266,437 bp
  • A to T, chromosome 6 at 41,614,373 bp
  • C to T, chromosome 6 at 46,530,202 bp
  • T to C, chromosome 6 at 73,144,963 bp
  • G to T, chromosome 6 at 96,165,289 bp
  • T to C, chromosome 6 at 113,194,136 bp
  • A to G, chromosome 6 at 130,119,018 bp
  • T to C, chromosome 6 at 148,157,458 bp
  • T to A, chromosome 7 at 13,285,340 bp
  • T to C, chromosome 7 at 31,360,287 bp
  • C to A, chromosome 7 at 78,914,509 bp
  • T to A, chromosome 7 at 108,825,924 bp
  • A to T, chromosome 7 at 126,387,407 bp
  • A to G, chromosome 8 at 35,825,930 bp
  • T to A, chromosome 8 at 83,932,373 bp
  • A to T, chromosome 8 at 93,062,978 bp
  • C to T, chromosome 9 at 38,464,631 bp
  • C to A, chromosome 9 at 41,043,500 bp
  • T to C, chromosome 9 at 50,688,664 bp
  • TCCC to TCC, chromosome 9 at 69,489,754 bp
  • T to A, chromosome 9 at 78,642,112 bp
  • C to T, chromosome 10 at 13,128,962 bp
  • T to C, chromosome 10 at 118,859,925 bp
  • A to G, chromosome 11 at 55,278,924 bp
  • G to T, chromosome 12 at 41,452,993 bp
  • T to A, chromosome 12 at 72,219,279 bp
  • A to C, chromosome 12 at 103,853,837 bp
  • T to A, chromosome 13 at 73,668,225 bp
  • G to T, chromosome 14 at 8,511,110 bp
  • G to T, chromosome 14 at 55,114,103 bp
  • A to G, chromosome 15 at 9,186,612 bp
  • T to C, chromosome 15 at 66,025,260 bp
  • A to T, chromosome 15 at 76,638,557 bp
  • A to G, chromosome 15 at 89,099,916 bp
  • A to T, chromosome 15 at 89,158,493 bp
  • A to G, chromosome 16 at 32,806,765 bp
  • A to G, chromosome 16 at 36,926,101 bp
  • A to G, chromosome 17 at 18,243,733 bp
  • A to G, chromosome 17 at 24,983,951 bp
  • T to C, chromosome 17 at 34,864,036 bp
  • C to T, chromosome 18 at 52,638,365 bp
  • A to G, chromosome 18 at 68,407,448 bp
  • A to T, chromosome 19 at 40,936,270 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1610 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039647-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.