Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR1620Btlr/Mmmh
Stock Number:
039657-MU
Citation ID:
RRID:MMRRC_039657-MU
Other Names:
R1620 (G1), C57BL/6J-MtgxR1620Btlr
Major Collection:

Strain Information

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Rc3h1
Name: RING CCCH (C3H) domains 1
Synonyms: roquin, 5730557L09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381305
Homologene: 19036
Lrrn1
Name: leucine rich repeat protein 1, neuronal
Synonyms: NLRR-1, 2810047E21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16979
Homologene: 32036
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Dlgap4
Name: DLG associated protein 4
Synonyms: WBP16, SAP90/PSD-95-associated protein 4, PSD-95/SAP90 binding protein 4, DAP4, Sapap4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228836
Homologene: 8935
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,536,473 bp
  • T to C, chromosome 1 at 39,333,912 bp
  • T to C, chromosome 1 at 57,409,985 bp
  • T to A, chromosome 1 at 77,374,926 bp
  • A to G, chromosome 1 at 85,254,186 bp
  • A to G, chromosome 1 at 87,449,128 bp
  • A to T, chromosome 1 at 87,994,225 bp
  • T to C, chromosome 1 at 160,954,973 bp
  • A to T, chromosome 1 at 182,517,137 bp
  • T to C, chromosome 1 at 187,183,215 bp
  • A to G, chromosome 2 at 61,650,098 bp
  • C to T, chromosome 2 at 65,529,375 bp
  • T to A, chromosome 2 at 67,510,835 bp
  • G to T, chromosome 2 at 112,042,246 bp
  • T to A, chromosome 2 at 156,749,136 bp
  • A to T, chromosome 3 at 29,987,088 bp
  • A to G, chromosome 3 at 131,302,701 bp
  • A to T, chromosome 5 at 21,519,421 bp
  • T to C, chromosome 5 at 124,832,643 bp
  • T to A, chromosome 6 at 3,965,507 bp
  • T to C, chromosome 6 at 103,690,242 bp
  • G to A, chromosome 6 at 107,568,366 bp
  • A to T, chromosome 6 at 115,473,281 bp
  • A to T, chromosome 6 at 123,125,100 bp
  • A to G, chromosome 7 at 15,397,041 bp
  • A to G, chromosome 7 at 23,418,639 bp
  • A to G, chromosome 7 at 23,606,329 bp
  • A to G, chromosome 7 at 46,078,151 bp
  • G to A, chromosome 7 at 46,249,124 bp
  • G to T, chromosome 7 at 66,381,538 bp
  • T to A, chromosome 8 at 83,249,595 bp
  • T to C, chromosome 8 at 119,749,126 bp
  • A to G, chromosome 9 at 18,510,477 bp
  • A to T, chromosome 9 at 108,574,655 bp
  • A to G, chromosome 9 at 118,843,502 bp
  • T to G, chromosome 9 at 121,204,805 bp
  • G to A, chromosome 10 at 41,922,296 bp
  • C to T, chromosome 10 at 82,884,015 bp
  • A to T, chromosome 11 at 54,626,594 bp
  • A to G, chromosome 11 at 65,196,394 bp
  • C to T, chromosome 11 at 67,088,736 bp
  • T to A, chromosome 11 at 99,865,056 bp
  • A to T, chromosome 11 at 120,366,685 bp
  • T to C, chromosome 12 at 4,826,808 bp
  • T to C, chromosome 12 at 115,067,875 bp
  • A to G, chromosome 13 at 22,244,963 bp
  • G to T, chromosome 13 at 43,094,897 bp
  • T to C, chromosome 13 at 67,842,990 bp
  • T to A, chromosome 14 at 59,791,183 bp
  • C to A, chromosome 14 at 79,863,229 bp
  • G to A, chromosome 14 at 93,888,305 bp
  • G to A, chromosome 15 at 78,888,470 bp
  • G to T, chromosome 16 at 13,688,846 bp
  • G to A, chromosome 17 at 46,647,499 bp
  • A to G, chromosome 17 at 67,767,033 bp
  • A to T, chromosome 17 at 73,316,308 bp
  • A to G, chromosome 17 at 88,635,816 bp
  • A to G, chromosome 18 at 15,498,106 bp
  • A to T, chromosome 18 at 44,337,058 bp
  • T to C, chromosome 19 at 6,838,149 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1620 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039657-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.