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Strain Name:
C57BL/6J-MtgxR1701Btlr/Mmmh
Stock Number:
039734-MU
Citation ID:
RRID:MMRRC_039734-MU
Other Names:
R1701 (G1), C57BL/6J-MtgxR1701Btlr
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Crhr2
Name: corticotropin releasing hormone receptor 2
Synonyms: Crfr2, CRF-R2, CRFR2beta, CRFR2alpha, CRF 2 receptor, CRH-R2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12922
HGNC: HGNC:2358
Homologene: 55612
Efemp1
Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216616
HGNC: HGNC:3218
Homologene: 3028
Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Rbpms
Name: RNA binding protein gene with multiple splicing
Synonyms: hermes, 2700019M19Rik, 2010300K22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19663
Homologene: 38238
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: Ctrn, citrin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50799
Homologene: 22800
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214812
Homologene: 72220
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Ube3c
Name: ubiquitin protein ligase E3C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100763
Homologene: 8783
Ints8
Name: integrator complex subunit 8
Synonyms: D130008D20Rik, 2810013E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72656
Homologene: 9888
Gpatch2l
Name: G patch domain containing 2 like
Synonyms: 1700020O03Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70373
VEGA: 12
Homologene: 9942
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: SPAG13, CS-1, CS1, KRAP, Ssfa2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Gbf1
Name: golgi-specific brefeldin A-resistance factor 1
Synonyms: 1700083E03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107338
HGNC: HGNC:4181
Homologene: 37897
Ctnnd1
Name: catenin delta 1
Synonyms: P120, Ctnnd, p120-catenin, Catns, catenin (cadherin associated protein), delta 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Anxa7
Name: annexin A7
Synonyms: synexin, Anx7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11750
VEGA: 14
HGNC: HGNC:545
Homologene: 36149
Ccdc88a
Name: coiled coil domain containing 88A
Synonyms: C330012F17Rik, D130005J21Rik, C130096N06Rik, GIV, HkRP1, Girdin, A430106J12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108686
Homologene: 41180
Robo4
Name: roundabout guidance receptor 4
Synonyms: 1200012D01Rik, Magic roundabout
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74144
Homologene: 10397
Slc35f5
Name: solute carrier family 35, member F5
Synonyms: 1300003P13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74150
Homologene: 5745
Pla2g7
Name: phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms: PAF acetylhydrolase, PAF-AH
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27226
HGNC: HGNC:9040
Homologene: 3725
Mtcl2
Name: microtubule crosslinking factor 2
Synonyms: D430036N24Rik, 9830001H06Rik, Soga1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320706
Homologene: 52382
Ctnnd2
Name: catenin delta 2
Synonyms: Nprap, Catnd2, neurojugin, catenin (cadherin associated protein), delta 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18163
VEGA: 15
HGNC: HGNC:2516
Homologene: 55574
Or5p76
Name: olfactory receptor family 5 subfamily P member 76
Synonyms: GA_x6K02T2PBJ9-10853935-10852991, MOR204-8, Olfr502
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258734
Homologene: 72021
Intu
Name: inturned planar cell polarity protein
Synonyms: 9430087H23Rik, 9230116I04Rik, Pdzk6, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Fam135b
Name: family with sequence similarity 135, member B
Synonyms: A830008O07Rik, 1700010C24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70363
VEGA: 15
Homologene: 66605
Myh8
Name: myosin, heavy polypeptide 8, skeletal muscle, perinatal
Synonyms: MyHC-pn, Myhs-p, Myhsp, 4832426G23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17885
HGNC: HGNC:7578
Homologene: 68256
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: D28, PTPROt, PTP-phi, PTP-BK, PTP-U2, GLEPP1, PTP-oc, Ptpn15
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: D11Ertd686e, Dnahc9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Vmn2r61
Name: vomeronasal 2, receptor 61
Synonyms: Casr-rs2, EG637873, Gprc2a-rs2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637873
Homologene: 129683
Or6c202
Name: olfactory receptor family 6 subfamily C member 202
Synonyms: GA_x6K02T2PULF-10846420-10845467, MOR114-8, Olfr771
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258540
Homologene: 74047
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Vmn2r25
Name: vomeronasal 2, receptor 25
Synonyms: EG545874
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 545874
Homologene: 135915
Aldh3a2
Name: aldehyde dehydrogenase family 3, subfamily A2
Synonyms: Ahd-3r, Ahd-3, Ahd3-r, Ahd3, Aldh4, Aldh4-r, FALDH
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11671
HGNC: HGNC:403
Homologene: 55458
AC132131.1
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Or8g4
Name: olfactory receptor family 8 subfamily G member 4
Synonyms: GA_x6K02T2PVTD-33447884-33448816, MOR171-30P, Olfr967
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258086
VEGA: 9
HGNC: HGNC:8484
Homologene: 115535
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Zfp879
Name: zinc finger protein 879
Synonyms: 9630041N07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 214779
Homologene: 45452
Hbb-bh2
Name: hemoglobin beta, bh2
Synonyms: Gm5736
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 436003
Tmc8
Name: transmembrane channel-like gene family 8
Synonyms: EVIN2, Ever2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217356
Homologene: 45126
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: A930009L15Rik, 4930544G21Rik, SKIP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Lgals3bp
Name: lectin, galactoside-binding, soluble, 3 binding protein
Synonyms: CyCAP, MAC-2BP, 90K, Ppicap, Tango10b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19039
HGNC: HGNC:6564
Homologene: 4067
Flot2
Name: flotillin 2
Synonyms: Esa, reggie-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V3R9, V1rd9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Pate8
Name: prostate and testis expressed 8
Synonyms: Gm17689
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 100312948
Selenbp1
Name: selenium binding protein 1
Synonyms: Lp56, Lpsb
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20341
Homologene: 2930
Or51a10
Name: olfactory receptor family 51 subfamily A member 10
Synonyms: GA_x6K02T2PBJ9-6784380-6783436, MOR13-6, Olfr642
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258326
Homologene: 17196
Phc2
Name: polyhomeotic 2
Synonyms: Mph2, D4Ertd810e, Edr2, D130050K19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54383
HGNC: HGNC:3183
Homologene: 75090
Acadsb
Name: acyl-Coenzyme A dehydrogenase, short/branched chain
Synonyms: 1300003O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66885
HGNC: HGNC:91
Homologene: 1216
Aadacl3
Name: arylacetamide deacetylase like 3
Synonyms: LOC230883
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230883
Homologene: 28426
Or5w16
Name: olfactory receptor family 5 subfamily W member 16
Synonyms: GA_x6K02T2Q125-49250025-49250960, MOR177-6, Olfr1140
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258635
Homologene: 74081
Trim30d
Name: tripartite motif-containing 30D
Synonyms: TRIM30-3, Trim79
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 209387
Homologene: 114426
Or5ac21
Name: olfactory receptor family 5 subfamily AC member 21
Synonyms: GA_x54KRFPKG5P-55517445-55518365, MOR182-5, Olfr203
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258479
Homologene: 122781
Slc26a10
Name: solute carrier family 26, member 10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216441
VEGA: 10
Homologene: 66953
Vmn1r180
Name: vomeronasal 1 receptor 180
Synonyms: LOC232962, V1rd16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232962
Homologene: 104166
Or2d3c
Name: olfactory receptor family 2 subfamily D member 3C
Synonyms: GA_x6K02T2PBJ9-9307730-9306814, MOR260-7, Olfr709
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258146
Or2h2
Name: olfactory receptor family 2 subfamily H member 2
Synonyms: MOR256-21, GA_x6K02T2PSCP-1526227-1525295, Olfr90
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258469
HGNC: HGNC:8253
Homologene: 68546
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 83,277,515 bp
  • A to G, chromosome 1 at 125,570,593 bp
  • A to T, chromosome 1 at 158,504,307 bp
  • A to G, chromosome 2 at 79,636,050 bp
  • T to C, chromosome 2 at 84,608,991 bp
  • T to A, chromosome 2 at 87,746,550 bp
  • T to C, chromosome 2 at 157,030,619 bp
  • A to G, chromosome 2 at 180,221,369 bp
  • T to A, chromosome 3 at 40,664,264 bp
  • C to A, chromosome 3 at 94,937,390 bp
  • T to C, chromosome 3 at 104,494,677 bp
  • A to G, chromosome 4 at 11,231,656 bp
  • C to T, chromosome 4 at 128,751,607 bp
  • A to G, chromosome 4 at 144,463,572 bp
  • G to A, chromosome 5 at 29,601,202 bp
  • G to A, chromosome 5 at 96,600,784 bp
  • T to C, chromosome 6 at 6,152,525 bp
  • T to C, chromosome 6 at 55,099,270 bp
  • T to A, chromosome 6 at 123,851,795 bp
  • T to A, chromosome 6 at 137,443,594 bp
  • A to T, chromosome 7 at 23,660,104 bp
  • T to C, chromosome 7 at 23,952,970 bp
  • T to C, chromosome 7 at 42,300,511 bp
  • T to A, chromosome 7 at 42,476,046 bp
  • G to A, chromosome 7 at 96,902,889 bp
  • T to C, chromosome 7 at 103,250,576 bp
  • T to C, chromosome 7 at 103,840,243 bp
  • T to C, chromosome 7 at 104,050,195 bp
  • C to T, chromosome 7 at 104,484,182 bp
  • C to A, chromosome 7 at 106,926,922 bp
  • T to G, chromosome 7 at 108,523,524 bp
  • T to A, chromosome 7 at 131,424,484 bp
  • A to T, chromosome 8 at 33,806,708 bp
  • A to G, chromosome 9 at 36,581,818 bp
  • G to T, chromosome 9 at 37,403,443 bp
  • A to T, chromosome 9 at 39,751,069 bp
  • T to C, chromosome 9 at 65,731,000 bp
  • A to G, chromosome 9 at 106,700,493 bp
  • A to G, chromosome 10 at 28,466,058 bp
  • T to G, chromosome 10 at 78,042,680 bp
  • T to C, chromosome 10 at 80,790,742 bp
  • T to C, chromosome 10 at 90,049,954 bp
  • C to T, chromosome 10 at 127,177,929 bp
  • T to C, chromosome 10 at 129,160,105 bp
  • A to G, chromosome 11 at 28,921,750 bp
  • T to C, chromosome 11 at 29,477,427 bp
  • A to G, chromosome 11 at 50,833,233 bp
  • C to T, chromosome 11 at 61,256,772 bp
  • A to G, chromosome 11 at 65,911,924 bp
  • G to T, chromosome 11 at 67,280,138 bp
  • C to T, chromosome 11 at 78,049,547 bp
  • A to G, chromosome 11 at 117,791,362 bp
  • T to C, chromosome 11 at 118,393,955 bp
  • A to G, chromosome 11 at 120,808,944 bp
  • A to G, chromosome 12 at 86,288,952 bp
  • A to T, chromosome 14 at 20,460,161 bp
  • G to A, chromosome 15 at 30,921,981 bp
  • T to C, chromosome 15 at 71,459,729 bp
  • T to C, chromosome 16 at 59,303,288 bp
  • C to T, chromosome 17 at 37,085,731 bp
  • T to C, chromosome 17 at 43,600,524 bp
  • T to A, chromosome 18 at 14,969,560 bp
  • T to C, chromosome 19 at 46,261,675 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1701 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039734-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.