Strain Name:
C57BL/6J-MtgxR1704Btlr/Mmmh
Stock Number:
039737-MU
Citation ID:
RRID:MMRRC_039737-MU
Other Names:
R1704 (G1), C57BL/6J-MtgxR1704Btlr
Major Collection:

Strain Information

Hfe
Name: homeostatic iron regulator
Synonyms: MR2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 15216
HGNC: HGNC:4886
Homologene: 88330
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 330286
Homologene: 19782
Avpr1b
Name: arginine vasopressin receptor 1B
Synonyms: V1BR, V3/V1b pituitary vasopressin receptor, V3/V1b, V1bR, AVPR3, VPR3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 26361
HGNC: HGNC:896
Homologene: 22678
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 68310
Homologene: 32904
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226409
Homologene: 32770
Kifap3
Name: kinesin-associated protein 3
Synonyms: KAP3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 16579
Homologene: 7799
Nf1
Name: neurofibromin 1
Synonyms: Nf-1, Dsk9, Mhdadsk9, neurofibromin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Kntc1
Name: kinetochore associated 1
Synonyms: jgl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 208628
Homologene: 32227
Lima1
Name: LIM domain and actin binding 1
Synonyms: EPLIN, epithelial protein lost in neoplasm, 1110021C24Rik, 3526402A12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 65970
Homologene: 9484
Sart3
Name: squamous cell carcinoma antigen recognized by T cells 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 53890
Homologene: 40977
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: 9330175N20Rik, RPC1, RPC155
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: par, 2310036I02Rik, Emv66
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Iars2
Name: isoleucine-tRNA synthetase 2, mitochondrial
Synonyms: 2010002H18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381314
Homologene: 7118
Sez6l2
Name: seizure related 6 homolog like 2
Synonyms: Psk1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233878
Homologene: 8237
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Camta1
Name: calmodulin binding transcription activator 1
Synonyms: 1810059M14Rik, 2310058O09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 100072
Homologene: 18942
Polr2b
Name: polymerase (RNA) II (DNA directed) polypeptide B
Synonyms: RPB2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231329
HGNC: HGNC:9188
Homologene: 722
Dsg4
Name: desmoglein 4
Synonyms: CDHF13, lah
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 16769
Homologene: 65341
Fat1
Name: FAT atypical cadherin 1
Synonyms: Fath, mFat1, 2310038E12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Frmd8
Name: FERM domain containing 8
Synonyms: 1200004M23Rik, 4931429L16Rik, 2310035N23Rik, iTAP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 67457
Homologene: 32653
Tmco1
Name: transmembrane and coiled-coil domains 1
Synonyms: 1190006A08Rik, 4930403O06Rik, ESTM39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 68944
Homologene: 10384
Fads1
Name: fatty acid desaturase 1
Synonyms: A930006B21Rik, 0710001O03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 76267
VEGA: 19
HGNC: HGNC:3574
Homologene: 22753
Fem1c
Name: fem 1 homolog c
Synonyms: 3632443A22Rik, 2610312A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 240263
Homologene: 10606
Susd4
Name: sushi domain containing 4
Synonyms: E430021N18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 96935
Homologene: 23062
Cep192
Name: centrosomal protein 192
Synonyms: D430014P18Rik, 4631422C13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 70799
VEGA: 18
Homologene: 73526
Cdh23
Name: cadherin 23 (otocadherin)
Synonyms: mdfw, nmf252, 4930542A03Rik, nmf112, ahl, sals, nmf181, bob, USH1D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 22295
Homologene: 11142
Crppa
Name: CDP-L-ribitol pyrophosphorylase A
Synonyms: Ispd, 4930579E17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 75847
VEGA: 12
Homologene: 45614
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: (alpha)1 subunit, L-type Cav1.2, Cav1.2, D930026N18Rik, Cchl1a1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Sox6
Name: SRY (sex determining region Y)-box 6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 20679
Homologene: 22631
Ush2a
Name: usherin
Synonyms: A930037M10Rik, MUSH2A, A930011D15Rik, LOC269160, Ushrn, Ush2a, LOC381317
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 22283
Homologene: 66151
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 320683
Homologene: 65318
Cntnap4
Name: contactin associated protein-like 4
Synonyms: Caspr4, E130114F09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 170571
Homologene: 24912
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 22635
Homologene: 124417
Adad1
Name: adenosine deaminase domain containing 1 (testis specific)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 21744
Homologene: 7569
Tshz3
Name: teashirt zinc finger family member 3
Synonyms: Zfp537, teashirt3, Tsh3, A630038G13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 243931
Homologene: 10835
Pdk2
Name: pyruvate dehydrogenase kinase, isoenzyme 2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18604
HGNC: HGNC:8810
Homologene: 68265
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D3Bwg1078e, D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 83679
Homologene: 66961
Sec11a
Name: SEC11 homolog A, signal peptidase complex subunit
Synonyms: Spc18, 1810012E07Rik, sid2895, Sec11l1, 18kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 56529
Homologene: 55536
C330019G07Rik
Name:
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Nos1ap
Name: nitric oxide synthase 1 (neuronal) adaptor protein
Synonyms: 6330408P19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 70729
Homologene: 135990
Gucy1a2
Name: guanylate cyclase 1, soluble, alpha 2
Synonyms: 6330407I18Rik, A230060L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 234889
HGNC: HGNC:4684
Homologene: 47953
Tex10
Name: testis expressed gene 10
Synonyms: 2610206N19Rik, clone 18330, 2810462N03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 269536
Homologene: 32361
Vmn2r9
Name: vomeronasal 2, receptor 9
Synonyms: EG435864
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 435864
Homologene: 129606
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 77652
VEGA: 17
Homologene: 104925
Snx14
Name: sorting nexin 14
Synonyms: YR-14, C330035N22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 244962
Homologene: 17823
Tnni3k
Name: TNNI3 interacting kinase
Synonyms: Cark, D830019J24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 435766
Homologene: 41084
Or1q1
Name: olfactory receptor family 1 subfamily Q member 1
Synonyms: GA_x6K02T2NLDC-33688556-33689482, Olfr357, MOR138-3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258616
HGNC: HGNC:8223
Homologene: 17320
Tgfbrap1
Name: transforming growth factor, beta receptor associated protein 1
Synonyms: 3110018K12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 73122
Homologene: 3141
Aldh1l2
Name: aldehyde dehydrogenase 1 family, member L2
Synonyms: D330038I09Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 216188
Homologene: 51942
Gbp10
Name: guanylate-binding protein 10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 626578
Homologene: 128731
Dhcr7
Name: 7-dehydrocholesterol reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13360
HGNC: HGNC:2860
Homologene: 1042
Ecm1
Name: extracellular matrix protein 1
Synonyms: p85
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 13601
HGNC: HGNC:3153
Homologene: 3260
Lipo1
Name: lipase, member O1
Synonyms: Gm5097
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 329055
Homologene: 86428
Rab43
Name: RAB43, member RAS oncogene family
Synonyms: 2500004H21Rik, 1810048P08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 69834
Homologene: 43122
Tmprss11a
Name: transmembrane protease, serine 11a
Synonyms: LOC194597
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 194597
Homologene: 62723
Ebna1bp2
Name: EBNA1 binding protein 2
Synonyms: p40, B830003A16Rik, Nobp, 1810014B19Rik, Ebp2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69072
Homologene: 4969
Apon
Name: apolipoprotein N
Synonyms: D10Ucla2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 28194
VEGA: 10
Homologene: 51183
Or2t43
Name: olfactory receptor family 2 subfamily T member 43
Synonyms: MOR275-10_p, MOR275-3, GA_x6K02T2NKPP-858022-858862, GA_x6K02T00261-652-347, Olfr327-ps1, Olfr224
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 258198
Homologene: 133015
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 43,054,656 bp
  • T to C, chromosome 1 at 128,092,003 bp
  • T to A, chromosome 1 at 131,609,504 bp
  • A to G, chromosome 1 at 163,829,196 bp
  • T to C, chromosome 1 at 167,325,937 bp
  • C to G, chromosome 1 at 170,338,212 bp
  • A to G, chromosome 1 at 182,854,113 bp
  • C to T, chromosome 1 at 185,325,489 bp
  • T to C, chromosome 1 at 188,821,796 bp
  • A to T, chromosome 2 at 36,996,884 bp
  • C to T, chromosome 3 at 37,092,015 bp
  • T to C, chromosome 3 at 95,737,005 bp
  • C to T, chromosome 3 at 97,754,260 bp
  • G to A, chromosome 3 at 154,827,508 bp
  • C to T, chromosome 4 at 48,456,800 bp
  • T to A, chromosome 4 at 118,623,603 bp
  • A to T, chromosome 4 at 127,048,384 bp
  • T to C, chromosome 4 at 151,075,224 bp
  • G to T, chromosome 5 at 32,830,282 bp
  • A to G, chromosome 5 at 77,342,560 bp
  • T to C, chromosome 5 at 86,428,702 bp
  • A to G, chromosome 5 at 105,224,351 bp
  • T to C, chromosome 5 at 108,846,400 bp
  • G to A, chromosome 5 at 113,746,007 bp
  • T to C, chromosome 5 at 123,771,156 bp
  • A to T, chromosome 5 at 137,434,002 bp
  • G to A, chromosome 6 at 38,139,427 bp
  • A to C, chromosome 6 at 87,811,381 bp
  • A to T, chromosome 6 at 118,602,146 bp
  • T to C, chromosome 7 at 36,771,360 bp
  • A to T, chromosome 7 at 80,935,100 bp
  • A to T, chromosome 7 at 115,476,948 bp
  • G to A, chromosome 7 at 126,958,341 bp
  • A to G, chromosome 7 at 127,610,864 bp
  • T to C, chromosome 7 at 143,837,990 bp
  • C to T, chromosome 8 at 45,025,576 bp
  • T to A, chromosome 8 at 112,757,523 bp
  • A to T, chromosome 9 at 3,582,705 bp
  • A to C, chromosome 9 at 88,413,538 bp
  • T to C, chromosome 9 at 119,609,394 bp
  • T to A, chromosome 10 at 60,314,611 bp
  • C to T, chromosome 10 at 83,508,660 bp
  • T to C, chromosome 10 at 128,254,996 bp
  • A to T, chromosome 11 at 58,566,754 bp
  • T to A, chromosome 11 at 79,463,301 bp
  • T to C, chromosome 11 at 95,028,550 bp
  • A to G, chromosome 12 at 36,521,494 bp
  • T to C, chromosome 13 at 23,704,408 bp
  • G to A, chromosome 14 at 24,484,120 bp
  • A to G, chromosome 15 at 99,819,736 bp
  • G to A, chromosome 17 at 33,241,725 bp
  • T to C, chromosome 18 at 20,471,589 bp
  • A to T, chromosome 18 at 46,506,196 bp
  • A to G, chromosome 18 at 67,434,244 bp
  • T to A, chromosome 18 at 67,856,256 bp
  • T to A, chromosome 19 at 5,869,482 bp
  • T to G, chromosome 19 at 10,191,508 bp
  • A to T, chromosome 19 at 33,780,343 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1704 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039737-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.