Strain Name:
C57BL/6J-MtgxR1707Btlr/Mmmh
Stock Number:
039740-MU
Citation ID:
RRID:MMRRC_039740-MU
Other Names:
R1707 (G1), C57BL/6J-MtgxR1707Btlr
Major Collection:

Gene Information

Gene Symbol: Tln2 [MGI:1917799] (Mus musculus (mouse))
Name: talin 2
Chromosome: 9
Alteration at locus: Chemically Induced
Gene Symbol: Mtmr3 [MGI:1921552] (Mus musculus (mouse))
Name: myotubularin related protein 3
Synonyms: 1700092A20Rik, FYVE-DSP1, ZFYVE10
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Colgalt2 [MGI:2138232] (Mus musculus (mouse))
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Chromosome: 1
Alteration at locus: Chemically Induced
Gene Symbol: Slc12a8 [MGI:2443672] (Mus musculus (mouse))
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Chromosome: 16
Alteration at locus: Chemically Induced
Gene Symbol: Dst [MGI:104627] (Mus musculus (mouse))
Name: dystonin
Synonyms: ah, 2310001O04Rik, bullous pemphigoid antigen 1, A830042E19Rik, Bpag, Macf2, athetoid, Bpag1, nmf339, nmf203, BPAG1, bullous pemphigoid antigen 1, BPAG1-n
Chromosome: 1
Alteration at locus: Chemically Induced
Gene Symbol: Dlc1 [MGI:1354949] (Mus musculus (mouse))
Name: deleted in liver cancer 1
Synonyms: A730069N07Rik, p122-RhoGAP, STARD12, Arhgap7
Chromosome: 8
Alteration at locus: Chemically Induced
Gene Symbol: Sash1 [MGI:1917347] (Mus musculus (mouse))
Name: SAM and SH3 domain containing 1
Synonyms: 1100001C18Rik, 2500002E12Rik, A330076K04Rik
Chromosome: 10
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 20,550,840 bp
  • G to T, chromosome 1 at 34,167,646 bp
  • C to T, chromosome 1 at 152,400,363 bp
  • A to T, chromosome 1 at 160,070,802 bp
  • T to C, chromosome 1 at 160,145,144 bp
  • T to C, chromosome 2 at 24,805,138 bp
  • T to A, chromosome 2 at 26,387,606 bp
  • T to C, chromosome 2 at 31,912,129 bp
  • G to A, chromosome 2 at 62,359,335 bp
  • C to T, chromosome 2 at 76,790,086 bp
  • A to G, chromosome 2 at 91,234,209 bp
  • A to T, chromosome 2 at 117,298,547 bp
  • G to A, chromosome 3 at 20,275,491 bp
  • T to A, chromosome 3 at 40,540,924 bp
  • C to A, chromosome 3 at 40,683,501 bp
  • A to G, chromosome 3 at 72,909,087 bp
  • A to G, chromosome 3 at 83,127,605 bp
  • G to A, chromosome 3 at 89,094,845 bp
  • A to G, chromosome 3 at 106,390,057 bp
  • T to C, chromosome 3 at 122,947,400 bp
  • A to G, chromosome 4 at 32,693,504 bp
  • T to A, chromosome 4 at 43,983,947 bp
  • A to C, chromosome 4 at 45,027,469 bp
  • T to A, chromosome 4 at 111,939,572 bp
  • T to A, chromosome 4 at 116,618,936 bp
  • T to G, chromosome 4 at 140,564,289 bp
  • A to G, chromosome 4 at 144,453,263 bp
  • T to G, chromosome 4 at 155,875,198 bp
  • G to A, chromosome 5 at 8,440,793 bp
  • T to C, chromosome 5 at 14,713,224 bp
  • T to G, chromosome 5 at 20,215,493 bp
  • G to A, chromosome 5 at 29,435,318 bp
  • T to A, chromosome 5 at 35,601,564 bp
  • T to A, chromosome 5 at 43,723,688 bp
  • T to C, chromosome 5 at 102,892,087 bp
  • T to A, chromosome 5 at 104,074,233 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • A to G, chromosome 5 at 116,482,551 bp
  • T to C, chromosome 5 at 134,216,987 bp
  • C to G, chromosome 6 at 38,636,794 bp
  • T to A, chromosome 6 at 48,477,877 bp
  • A to G, chromosome 6 at 57,956,512 bp
  • G to A, chromosome 6 at 71,326,184 bp
  • A to T, chromosome 6 at 87,905,210 bp
  • C to T, chromosome 6 at 116,641,676 bp
  • G to A, chromosome 6 at 131,284,637 bp
  • T to A, chromosome 7 at 11,847,577 bp
  • A to T, chromosome 7 at 73,417,959 bp
  • A to T, chromosome 7 at 96,888,685 bp
  • C to T, chromosome 7 at 127,001,572 bp
  • A to G, chromosome 8 at 36,937,609 bp
  • A to C, chromosome 8 at 88,670,476 bp
  • T to A, chromosome 9 at 4,316,985 bp
  • G to A, chromosome 9 at 8,100,382 bp
  • A to T, chromosome 9 at 31,150,919 bp
  • T to A, chromosome 9 at 38,329,901 bp
  • C to T, chromosome 9 at 67,375,807 bp
  • T to C, chromosome 9 at 80,378,517 bp
  • G to A, chromosome 9 at 89,702,780 bp
  • A to T, chromosome 9 at 120,018,775 bp
  • A to G, chromosome 10 at 8,730,377 bp
  • G to A, chromosome 10 at 31,248,462 bp
  • A to T, chromosome 10 at 80,521,801 bp
  • C to T, chromosome 10 at 127,328,889 bp
  • T to C, chromosome 11 at 4,504,095 bp
  • C to T, chromosome 11 at 70,728,397 bp
  • T to A, chromosome 11 at 79,535,604 bp
  • T to C, chromosome 11 at 106,376,683 bp
  • A to T, chromosome 12 at 78,797,401 bp
  • A to G, chromosome 13 at 47,961,005 bp
  • A to T, chromosome 13 at 100,242,855 bp
  • T to G, chromosome 14 at 26,901,122 bp
  • A to T, chromosome 14 at 34,425,141 bp
  • G to T, chromosome 14 at 61,209,762 bp
  • A to G, chromosome 14 at 65,921,201 bp
  • G to T, chromosome 15 at 74,529,343 bp
  • T to A, chromosome 15 at 102,179,972 bp
  • A to T, chromosome 16 at 16,780,628 bp
  • T to C, chromosome 16 at 19,530,177 bp
  • A to G, chromosome 16 at 29,228,226 bp
  • A to G, chromosome 16 at 33,551,007 bp
  • A to C, chromosome 16 at 35,857,849 bp
  • A to C, chromosome 16 at 49,018,404 bp
  • G to T, chromosome 16 at 57,266,480 bp
  • C to T, chromosome 16 at 90,386,407 bp
  • T to G, chromosome 17 at 36,548,766 bp
  • A to T, chromosome 17 at 80,275,226 bp
  • A to T, chromosome 18 at 47,283,445 bp
  • A to C, chromosome 19 at 34,238,821 bp
  • A to G, chromosome 19 at 57,686,737 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1707 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039740-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.