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Strain Name:
C57BL/6J-MtgxR1735Btlr/Mmmh
Stock Number:
039767-MU
Citation ID:
RRID:MMRRC_039767-MU
Other Names:
R1735 (G1), C57BL/6J-MtgxR1735Btlr
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, Dmdl, DRP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p85alpha, p50alpha, p55alpha, PI3K
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Gpd2
Name: glycerol phosphate dehydrogenase 2, mitochondrial
Synonyms: Gdm1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14571
HGNC: HGNC:4456
Homologene: 352
Ppp1r16b
Name: protein phosphatase 1, regulatory subunit 16B
Synonyms: ANKRD4, Wdt4, C130078N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228852
Homologene: 9194
Htr2a
Name: 5-hydroxytryptamine (serotonin) receptor 2A
Synonyms: 5-HT2A receptor, Htr-2, Htr2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 15558
VEGA: 14
HGNC: HGNC:5293
Homologene: 68073
Bcap29
Name: B cell receptor associated protein 29
Synonyms: Bap29
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12033
VEGA: 12
Homologene: 22411
Fastk
Name: Fas-activated serine/threonine kinase
Synonyms: 0610011K02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66587
Homologene: 4884
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 21,350,965 bp
  • A to G, chromosome 1 at 55,000,652 bp
  • A to T, chromosome 1 at 111,860,915 bp
  • T to A, chromosome 1 at 155,953,214 bp
  • T to C, chromosome 1 at 157,174,160 bp
  • C to A, chromosome 1 at 170,907,332 bp
  • A to G, chromosome 1 at 172,956,807 bp
  • A to T, chromosome 1 at 174,050,799 bp
  • T to A, chromosome 2 at 57,355,551 bp
  • A to T, chromosome 2 at 70,009,129 bp
  • T to A, chromosome 2 at 147,061,423 bp
  • G to A, chromosome 2 at 153,232,477 bp
  • A to G, chromosome 2 at 158,761,495 bp
  • G to A, chromosome 3 at 61,363,940 bp
  • T to C, chromosome 3 at 82,897,110 bp
  • A to T, chromosome 3 at 88,073,094 bp
  • T to A, chromosome 3 at 95,895,509 bp
  • T to C, chromosome 3 at 106,735,846 bp
  • C to T, chromosome 4 at 86,289,714 bp
  • A to G, chromosome 4 at 113,563,459 bp
  • T to C, chromosome 4 at 118,014,774 bp
  • A to G, chromosome 4 at 125,071,201 bp
  • G to T, chromosome 4 at 129,223,577 bp
  • G to T, chromosome 4 at 141,249,618 bp
  • T to C, chromosome 5 at 24,441,803 bp
  • T to C, chromosome 5 at 65,808,316 bp
  • T to C, chromosome 5 at 77,006,626 bp
  • T to G, chromosome 6 at 128,405,074 bp
  • T to A, chromosome 7 at 103,470,146 bp
  • T to C, chromosome 7 at 112,303,575 bp
  • A to G, chromosome 7 at 126,444,540 bp
  • T to A, chromosome 8 at 15,932,610 bp
  • T to C, chromosome 8 at 46,011,988 bp
  • T to A, chromosome 8 at 70,578,940 bp
  • A to G, chromosome 8 at 78,506,082 bp
  • A to G, chromosome 8 at 106,083,834 bp
  • A to C, chromosome 9 at 8,027,265 bp
  • T to C, chromosome 9 at 27,085,932 bp
  • G to T, chromosome 9 at 65,703,092 bp
  • C to T, chromosome 9 at 110,034,955 bp
  • T to C, chromosome 9 at 121,779,938 bp
  • T to A, chromosome 10 at 12,710,138 bp
  • C to A, chromosome 10 at 17,724,046 bp
  • C to T, chromosome 10 at 27,176,658 bp
  • A to G, chromosome 10 at 51,587,211 bp
  • T to G, chromosome 10 at 100,595,167 bp
  • T to C, chromosome 10 at 127,884,585 bp
  • C to A, chromosome 11 at 46,138,917 bp
  • A to G, chromosome 11 at 59,086,657 bp
  • A to G, chromosome 11 at 69,742,396 bp
  • G to T, chromosome 11 at 78,058,005 bp
  • A to G, chromosome 11 at 95,890,983 bp
  • T to C, chromosome 11 at 102,885,780 bp
  • A to G, chromosome 11 at 120,629,678 bp
  • T to A, chromosome 11 at 121,945,548 bp
  • T to A, chromosome 12 at 31,630,840 bp
  • T to C, chromosome 12 at 50,342,039 bp
  • A to T, chromosome 12 at 84,075,487 bp
  • C to T, chromosome 12 at 98,758,580 bp
  • T to C, chromosome 13 at 4,487,208 bp
  • A to T, chromosome 13 at 14,377,765 bp
  • A to G, chromosome 13 at 81,487,947 bp
  • A to T, chromosome 13 at 93,089,789 bp
  • G to A, chromosome 13 at 94,493,717 bp
  • A to G, chromosome 13 at 100,763,544 bp
  • A to T, chromosome 13 at 101,686,374 bp
  • T to C, chromosome 13 at 112,945,086 bp
  • C to T, chromosome 14 at 8,222,253 bp
  • T to A, chromosome 14 at 66,088,303 bp
  • T to C, chromosome 14 at 74,706,128 bp
  • T to A, chromosome 14 at 75,729,321 bp
  • T to C, chromosome 14 at 123,294,323 bp
  • T to A, chromosome 15 at 21,520,366 bp
  • T to C, chromosome 15 at 76,347,936 bp
  • T to C, chromosome 15 at 83,607,437 bp
  • A to G, chromosome 15 at 101,015,861 bp
  • T to C, chromosome 16 at 55,990,682 bp
  • T to C, chromosome 17 at 6,715,481 bp
  • C to T, chromosome 17 at 7,775,368 bp
  • C to T, chromosome 17 at 34,717,970 bp
  • T to A, chromosome 17 at 45,632,401 bp
  • G to A, chromosome 17 at 56,614,956 bp
  • A to T, chromosome 18 at 37,490,769 bp
  • A to G, chromosome 18 at 46,990,485 bp
  • A to C, chromosome 18 at 77,404,889 bp
  • T to A, chromosome 19 at 4,858,091 bp
  • T to C, chromosome 19 at 7,457,911 bp
  • T to A, chromosome 19 at 12,934,843 bp
  • C to A, chromosome 19 at 61,226,344 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1735 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039767-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.