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Strain Name:
C57BL/6J-MtgxR1742Btlr/Mmmh
Stock Number:
039774-MU
Citation ID:
RRID:MMRRC_039774-MU
Other Names:
R1742 (G1), C57BL/6J-MtgxR1742Btlr
Major Collection:

Strain Information

Drd2
Name: dopamine receptor D2
Synonyms: D2 receptor, D2R, Drd-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Atf2
Name: activating transcription factor 2
Synonyms: mXBP, CRE-BP, Creb2, D130078H02Rik, ATF-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11909
HGNC: HGNC:784
Homologene: 31061
Ptdss2
Name: phosphatidylserine synthase 2
Synonyms: PSS2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27388
Homologene: 8462
Phf12
Name: PHD finger protein 12
Synonyms: PF1, 2410142K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268448
Homologene: 10841
Arfgef2
Name: ARF guanine nucleotide exchange factor 2
Synonyms: BIG2, E230011G24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99371
Homologene: 111880
Oxr1
Name: oxidation resistance 1
Synonyms: C7B, C7, 2210416C20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170719
VEGA: 15
Homologene: 24993
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 53,456,684 bp
  • C to A, chromosome 1 at 65,103,121 bp
  • T to C, chromosome 1 at 90,098,051 bp
  • T to A, chromosome 1 at 90,813,794 bp
  • A to G, chromosome 1 at 118,964,436 bp
  • T to A, chromosome 1 at 123,445,206 bp
  • A to G, chromosome 1 at 130,845,086 bp
  • T to A, chromosome 1 at 132,228,298 bp
  • A to G, chromosome 1 at 150,104,399 bp
  • G to A, chromosome 1 at 173,481,971 bp
  • A to T, chromosome 1 at 195,158,759 bp
  • A to G, chromosome 2 at 73,819,152 bp
  • G to A, chromosome 2 at 76,682,879 bp
  • T to A, chromosome 2 at 87,252,778 bp
  • G to T, chromosome 2 at 89,296,424 bp
  • A to T, chromosome 2 at 93,841,299 bp
  • A to T, chromosome 2 at 130,740,395 bp
  • G to A, chromosome 2 at 163,225,526 bp
  • A to G, chromosome 2 at 166,866,980 bp
  • T to C, chromosome 3 at 87,259,043 bp
  • A to G, chromosome 3 at 89,952,664 bp
  • T to G, chromosome 3 at 116,607,477 bp
  • A to T, chromosome 3 at 146,469,623 bp
  • T to C, chromosome 4 at 41,712,763 bp
  • T to C, chromosome 4 at 73,401,210 bp
  • T to A, chromosome 4 at 83,681,284 bp
  • T to A, chromosome 5 at 146,846,995 bp
  • C to A, chromosome 5 at 148,959,501 bp
  • T to A, chromosome 6 at 43,280,199 bp
  • C to A, chromosome 6 at 77,244,091 bp
  • T to C, chromosome 6 at 124,200,677 bp
  • T to C, chromosome 6 at 125,667,550 bp
  • T to A, chromosome 6 at 141,825,045 bp
  • T to C, chromosome 6 at 142,364,572 bp
  • A to G, chromosome 7 at 25,224,514 bp
  • T to C, chromosome 7 at 28,294,423 bp
  • A to T, chromosome 7 at 68,237,054 bp
  • T to A, chromosome 7 at 86,795,335 bp
  • T to C, chromosome 7 at 87,295,818 bp
  • A to G, chromosome 7 at 141,130,367 bp
  • C to A, chromosome 7 at 141,892,855 bp
  • G to A, chromosome 8 at 18,607,363 bp
  • T to A, chromosome 8 at 120,566,950 bp
  • T to A, chromosome 8 at 124,380,307 bp
  • T to C, chromosome 9 at 7,503,138 bp
  • A to G, chromosome 9 at 19,478,041 bp
  • T to C, chromosome 9 at 49,400,729 bp
  • T to A, chromosome 9 at 65,587,850 bp
  • A to T, chromosome 9 at 70,820,529 bp
  • T to C, chromosome 9 at 91,361,576 bp
  • T to C, chromosome 10 at 21,347,247 bp
  • G to A, chromosome 10 at 23,993,219 bp
  • C to T, chromosome 10 at 45,347,865 bp
  • C to A, chromosome 10 at 63,287,949 bp
  • T to G, chromosome 10 at 81,046,277 bp
  • T to C, chromosome 10 at 109,769,213 bp
  • T to A, chromosome 11 at 29,557,647 bp
  • T to A, chromosome 11 at 29,733,847 bp
  • C to A, chromosome 11 at 77,467,738 bp
  • TC to T, chromosome 11 at 77,786,002 bp
  • G to T, chromosome 11 at 77,841,467 bp
  • C to T, chromosome 11 at 78,009,486 bp
  • A to G, chromosome 11 at 107,110,951 bp
  • T to C, chromosome 12 at 52,024,262 bp
  • C to T, chromosome 12 at 88,249,683 bp
  • A to G, chromosome 12 at 118,849,817 bp
  • G to A, chromosome 13 at 52,835,496 bp
  • C to T, chromosome 13 at 76,180,038 bp
  • C to T, chromosome 13 at 98,316,296 bp
  • T to A, chromosome 14 at 20,141,857 bp
  • A to G, chromosome 14 at 54,711,600 bp
  • T to C, chromosome 15 at 41,850,559 bp
  • C to T, chromosome 15 at 71,801,913 bp
  • A to T, chromosome 16 at 14,220,044 bp
  • C to T, chromosome 16 at 32,905,553 bp
  • T to C, chromosome 16 at 50,590,238 bp
  • T to G, chromosome 16 at 91,816,959 bp
  • C to T, chromosome 17 at 25,567,941 bp
  • T to A, chromosome 17 at 33,937,223 bp
  • T to C, chromosome 17 at 34,928,411 bp
  • C to A, chromosome 18 at 36,625,265 bp
  • T to C, chromosome 18 at 37,486,576 bp
  • C to T, chromosome 18 at 64,564,329 bp
  • T to C, chromosome 18 at 73,675,897 bp
  • T to C, chromosome 19 at 36,876,261 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1742 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039774-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.