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Strain Name:
C57BL/6J-MtgxR1752Btlr/Mmmh
Stock Number:
039784-MU
Citation ID:
RRID:MMRRC_039784-MU
Other Names:
R1752 (G1), C57BL/6J-MtgxR1752Btlr
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Ldb1
Name: LIM domain binding 1
Synonyms: CLIM2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16825
HGNC: HGNC:6532
Homologene: 2891
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Slit3
Name: slit guidance ligand 3
Synonyms: Slit1, b2b2362.1Clo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Manba
Name: mannosidase, beta A, lysosomal
Synonyms: Bmn, 2410030O07Rik, B930014J03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110173
HGNC: HGNC:6831
Homologene: 4317
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,629,261 bp
  • T to A, chromosome 1 at 62,738,441 bp
  • T to A, chromosome 1 at 95,591,812 bp
  • T to C, chromosome 1 at 131,977,521 bp
  • T to C, chromosome 1 at 166,408,428 bp
  • T to C, chromosome 2 at 32,673,392 bp
  • A to T, chromosome 2 at 32,772,150 bp
  • T to C, chromosome 2 at 62,334,245 bp
  • T to C, chromosome 2 at 73,310,538 bp
  • A to G, chromosome 2 at 76,764,262 bp
  • T to A, chromosome 2 at 76,944,104 bp
  • C to A, chromosome 2 at 88,987,315 bp
  • C to T, chromosome 2 at 93,858,030 bp
  • G to T, chromosome 2 at 142,690,666 bp
  • A to G, chromosome 2 at 173,157,113 bp
  • C to T, chromosome 3 at 86,806,127 bp
  • G to A, chromosome 3 at 101,276,195 bp
  • T to C, chromosome 3 at 108,869,330 bp
  • T to A, chromosome 3 at 135,506,945 bp
  • T to C, chromosome 4 at 43,536,311 bp
  • T to C, chromosome 4 at 44,609,729 bp
  • A to G, chromosome 4 at 98,966,444 bp
  • A to T, chromosome 4 at 108,205,282 bp
  • C to A, chromosome 4 at 108,512,863 bp
  • T to C, chromosome 4 at 123,483,672 bp
  • T to A, chromosome 4 at 134,073,650 bp
  • T to G, chromosome 4 at 141,251,043 bp
  • A to T, chromosome 4 at 152,375,133 bp
  • A to G, chromosome 5 at 23,528,019 bp
  • A to G, chromosome 5 at 29,477,729 bp
  • A to T, chromosome 5 at 72,540,875 bp
  • A to C, chromosome 5 at 72,577,372 bp
  • T to C, chromosome 5 at 93,202,456 bp
  • A to T, chromosome 5 at 110,123,773 bp
  • C to A, chromosome 5 at 144,555,361 bp
  • A to G, chromosome 6 at 30,552,024 bp
  • T to C, chromosome 6 at 40,582,253 bp
  • A to G, chromosome 6 at 52,721,413 bp
  • A to G, chromosome 6 at 55,679,526 bp
  • A to G, chromosome 6 at 124,810,329 bp
  • T to C, chromosome 7 at 26,672,719 bp
  • T to C, chromosome 7 at 43,532,298 bp
  • T to G, chromosome 7 at 44,764,768 bp
  • T to C, chromosome 7 at 55,264,340 bp
  • T to A, chromosome 7 at 103,506,558 bp
  • G to A, chromosome 7 at 140,153,495 bp
  • T to G, chromosome 7 at 141,867,751 bp
  • C to T, chromosome 8 at 12,813,094 bp
  • A to C, chromosome 8 at 13,291,741 bp
  • A to G, chromosome 8 at 55,872,274 bp
  • A to G, chromosome 8 at 84,925,336 bp
  • A to G, chromosome 8 at 104,619,873 bp
  • A to G, chromosome 9 at 50,682,550 bp
  • C to G, chromosome 9 at 66,220,643 bp
  • T to A, chromosome 9 at 107,592,070 bp
  • T to C, chromosome 9 at 108,374,242 bp
  • T to A, chromosome 9 at 110,594,605 bp
  • A to T, chromosome 10 at 11,609,543 bp
  • T to C, chromosome 10 at 21,156,437 bp
  • A to G, chromosome 10 at 25,460,792 bp
  • T to C, chromosome 10 at 53,674,570 bp
  • T to A, chromosome 10 at 62,812,989 bp
  • T to C, chromosome 10 at 80,006,634 bp
  • T to A, chromosome 10 at 116,340,990 bp
  • A to T, chromosome 11 at 35,564,653 bp
  • T to C, chromosome 11 at 53,186,795 bp
  • T to A, chromosome 11 at 69,856,706 bp
  • T to C, chromosome 11 at 78,053,462 bp
  • T to C, chromosome 11 at 82,046,635 bp
  • T to A, chromosome 11 at 100,884,058 bp
  • T to A, chromosome 11 at 103,080,259 bp
  • T to C, chromosome 11 at 103,614,555 bp
  • T to C, chromosome 11 at 116,535,245 bp
  • T to G, chromosome 12 at 4,711,950 bp
  • T to C, chromosome 12 at 7,988,766 bp
  • A to T, chromosome 12 at 31,641,731 bp
  • A to T, chromosome 12 at 116,426,718 bp
  • T to A, chromosome 13 at 42,303,599 bp
  • A to T, chromosome 13 at 46,798,409 bp
  • T to C, chromosome 13 at 91,805,780 bp
  • T to A, chromosome 14 at 27,471,928 bp
  • A to C, chromosome 14 at 66,916,336 bp
  • T to A, chromosome 14 at 73,287,624 bp
  • T to C, chromosome 15 at 47,660,273 bp
  • T to C, chromosome 15 at 76,853,663 bp
  • A to T, chromosome 15 at 100,405,806 bp
  • T to C, chromosome 16 at 33,204,835 bp
  • A to T, chromosome 16 at 55,866,474 bp
  • T to C, chromosome 16 at 90,938,473 bp
  • T to C, chromosome 17 at 15,743,232 bp
  • C to A, chromosome 17 at 17,383,277 bp
  • T to A, chromosome 17 at 21,199,721 bp
  • T to C, chromosome 17 at 33,819,817 bp
  • G to A, chromosome 17 at 46,653,167 bp
  • C to T, chromosome 17 at 53,964,749 bp
  • A to G, chromosome 17 at 65,824,799 bp
  • A to G, chromosome 18 at 34,631,581 bp
  • T to C, chromosome 18 at 50,170,767 bp
  • T to C, chromosome 18 at 68,321,310 bp
  • C to A, chromosome 19 at 5,745,657 bp
  • T to A, chromosome 19 at 6,391,034 bp
  • C to T, chromosome 19 at 6,853,322 bp
  • T to A, chromosome 19 at 34,938,336 bp
  • T to A, chromosome 19 at 39,881,153 bp
  • A to T, chromosome 19 at 46,034,032 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1752 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039784-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.