Strain Name:
C57BL/6J-MtgxR1780Btlr/Mmmh
Stock Number:
039811-MU
Citation ID:
RRID:MMRRC_039811-MU
Other Names:
R1780 (G1), C57BL/6J-MtgxR1780Btlr
Major Collection:

Gene Information

Gene Symbol: Pkd1 [MGI:97603] (Mus musculus (mouse))
Name: polycystin 1, transient receptor poteintial channel interacting
Synonyms: PC1, PC-1, polycystin-1
Chromosome: 17
Alteration at locus: Chemically Induced
Gene Symbol: Rgs9 [MGI:1338824] (Mus musculus (mouse))
Name: regulator of G-protein signaling 9
Synonyms: RGS9-1, Rgs9-2
Chromosome: 11
Alteration at locus: Chemically Induced
Gene Symbol: Ubp1 [MGI:104889] (Mus musculus (mouse))
Name: upstream binding protein 1
Synonyms: NF2d9, LBP-1a, LBP-1b
Chromosome: 9
Alteration at locus: Chemically Induced
Gene Symbol: Tmed10 [MGI:1915831] (Mus musculus (mouse))
Name: transmembrane p24 trafficking protein 10
Synonyms: p24delta1, p23, 1110014C03Rik
Chromosome: 12
Alteration at locus: Chemically Induced
Gene Symbol: Phf3 [MGI:2446126] (Mus musculus (mouse))
Name: PHD finger protein 3
Synonyms: AU020177, 2310061N19Rik
Chromosome: 1
Alteration at locus: Chemically Induced
Gene Symbol: Ankrd17 [MGI:1932101] (Mus musculus (mouse))
Name: ankyrin repeat domain 17
Synonyms: A130069E23Rik, 4933425K22Rik, Gtar
Chromosome: 5
Alteration at locus: Chemically Induced
Gene Symbol: Pogz [MGI:2442117] (Mus musculus (mouse))
Name: pogo transposable element with ZNF domain
Synonyms: 9530006B08Rik
Chromosome: 3
Alteration at locus: Chemically Induced
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,811,942 bp
  • T to A, chromosome 1 at 34,724,160 bp
  • A to T, chromosome 1 at 38,535,702 bp
  • T to A, chromosome 1 at 44,167,796 bp
  • T to C, chromosome 1 at 87,192,548 bp
  • C to T, chromosome 1 at 88,230,680 bp
  • G to A, chromosome 1 at 92,588,389 bp
  • A to T, chromosome 1 at 153,112,440 bp
  • T to C, chromosome 2 at 25,084,306 bp
  • T to C, chromosome 2 at 76,810,699 bp
  • T to C, chromosome 2 at 111,231,698 bp
  • C to T, chromosome 2 at 112,867,292 bp
  • G to A, chromosome 2 at 153,225,256 bp
  • T to C, chromosome 2 at 165,406,699 bp
  • A to G, chromosome 3 at 29,980,971 bp
  • A to G, chromosome 3 at 36,046,699 bp
  • A to G, chromosome 3 at 73,700,620 bp
  • G to C, chromosome 3 at 88,057,133 bp
  • A to G, chromosome 3 at 88,965,984 bp
  • A to G, chromosome 3 at 93,202,999 bp
  • A to T, chromosome 3 at 94,870,126 bp
  • T to C, chromosome 3 at 148,852,593 bp
  • T to C, chromosome 4 at 32,700,103 bp
  • T to C, chromosome 4 at 47,122,424 bp
  • A to G, chromosome 4 at 125,007,745 bp
  • T to A, chromosome 4 at 141,002,460 bp
  • T to C, chromosome 4 at 156,351,373 bp
  • T to C, chromosome 5 at 24,533,676 bp
  • A to T, chromosome 5 at 24,863,899 bp
  • A to G, chromosome 5 at 35,064,574 bp
  • T to A, chromosome 5 at 90,232,415 bp
  • A to T, chromosome 5 at 100,381,336 bp
  • A to G, chromosome 5 at 137,796,652 bp
  • C to T, chromosome 6 at 23,320,932 bp
  • C to T, chromosome 6 at 24,734,032 bp
  • C to T, chromosome 6 at 30,643,008 bp
  • A to G, chromosome 6 at 123,828,465 bp
  • C to T, chromosome 6 at 134,464,451 bp
  • T to A, chromosome 6 at 142,364,598 bp
  • A to G, chromosome 7 at 26,841,876 bp
  • A to G, chromosome 7 at 45,635,318 bp
  • A to C, chromosome 7 at 45,678,832 bp
  • A to G, chromosome 7 at 102,684,073 bp
  • A to G, chromosome 7 at 103,881,592 bp
  • A to T, chromosome 7 at 103,893,555 bp
  • T to C, chromosome 7 at 118,155,912 bp
  • T to A, chromosome 8 at 11,231,389 bp
  • T to C, chromosome 9 at 83,953,783 bp
  • T to G, chromosome 9 at 86,556,204 bp
  • C to T, chromosome 9 at 98,354,111 bp
  • A to T, chromosome 9 at 105,936,878 bp
  • G to A, chromosome 9 at 113,964,579 bp
  • A to G, chromosome 10 at 62,594,147 bp
  • T to C, chromosome 10 at 63,121,964 bp
  • A to G, chromosome 10 at 106,896,507 bp
  • A to G, chromosome 10 at 127,994,327 bp
  • T to A, chromosome 11 at 74,946,116 bp
  • A to T, chromosome 11 at 102,314,918 bp
  • A to T, chromosome 11 at 109,239,499 bp
  • C to A, chromosome 11 at 116,600,513 bp
  • A to G, chromosome 12 at 85,354,879 bp
  • A to G, chromosome 12 at 103,451,319 bp
  • A to T, chromosome 12 at 111,322,907 bp
  • A to T, chromosome 12 at 118,027,558 bp
  • T to G, chromosome 13 at 17,452,454 bp
  • C to A, chromosome 14 at 20,716,327 bp
  • T to C, chromosome 14 at 21,041,070 bp
  • T to A, chromosome 14 at 51,418,572 bp
  • A to G, chromosome 14 at 60,691,725 bp
  • A to T, chromosome 15 at 27,660,027 bp
  • A to G, chromosome 15 at 27,744,038 bp
  • A to C, chromosome 15 at 72,512,401 bp
  • T to C, chromosome 15 at 82,794,007 bp
  • C to T, chromosome 15 at 84,211,127 bp
  • T to C, chromosome 16 at 17,212,632 bp
  • A to G, chromosome 16 at 65,523,470 bp
  • C to T, chromosome 16 at 70,495,324 bp
  • T to C, chromosome 16 at 97,451,512 bp
  • T to C, chromosome 17 at 21,261,737 bp
  • T to G, chromosome 17 at 24,581,569 bp
  • T to A, chromosome 17 at 75,151,254 bp
  • T to C, chromosome 17 at 86,057,685 bp
  • T to C, chromosome 18 at 31,961,185 bp
  • A to T, chromosome 18 at 78,023,990 bp
  • A to T, chromosome 18 at 80,776,897 bp
  • T to C, chromosome 19 at 4,883,766 bp
  • A to G, chromosome 19 at 13,471,362 bp
  • C to A, chromosome 19 at 39,538,851 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1780 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
039811-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials and based on the transfer success rate of the MMRRC facility) to transfer to at least two recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.