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Strain Name:
C57BL/6J-MtgxR1782Btlr/Mmmh
Stock Number:
039813-MU
Citation ID:
RRID:MMRRC_039813-MU
Other Names:
R1782 (G1), C57BL/6J-MtgxR1782Btlr
Major Collection:

Strain Information

Hgs
Name: HGF-regulated tyrosine kinase substrate
Synonyms: Hrs, tn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15239
HGNC: HGNC:4897
Homologene: 37954
Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik, D630049N15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Chat
Name: choline O-acetyltransferase
Synonyms: B230380D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12647
VEGA: 14
HGNC: HGNC:1912
Homologene: 40693
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Wdr73
Name: WD repeat domain 73
Synonyms: 1200011I23Rik, 2410008B13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71968
Homologene: 41899
Taf8
Name: TATA-box binding protein associated factor 8
Synonyms: Taf8, Tbn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63856
VEGA: 17
Homologene: 11094
Macroh2a1
Name: macroH2A.1 histone
Synonyms: mH2a1, MACROH2A1.2, H2AF12M, H2afy
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 4,349,089 bp
  • A to T, chromosome 1 at 20,565,711 bp
  • T to A, chromosome 1 at 91,308,380 bp
  • C to G, chromosome 1 at 134,987,979 bp
  • A to G, chromosome 1 at 151,356,239 bp
  • T to C, chromosome 1 at 188,911,185 bp
  • T to A, chromosome 2 at 25,499,082 bp
  • T to A, chromosome 2 at 52,284,345 bp
  • T to A, chromosome 2 at 62,736,169 bp
  • T to C, chromosome 2 at 76,735,487 bp
  • T to C, chromosome 2 at 86,732,682 bp
  • T to A, chromosome 2 at 126,720,051 bp
  • G to A, chromosome 2 at 165,445,519 bp
  • A to T, chromosome 2 at 181,383,056 bp
  • T to C, chromosome 3 at 79,886,531 bp
  • T to C, chromosome 3 at 84,903,819 bp
  • T to C, chromosome 3 at 90,341,871 bp
  • T to C, chromosome 3 at 94,344,489 bp
  • C to T, chromosome 3 at 98,320,747 bp
  • T to A, chromosome 3 at 100,010,754 bp
  • C to T, chromosome 3 at 151,542,805 bp
  • G to A, chromosome 4 at 33,085,593 bp
  • A to G, chromosome 4 at 98,934,198 bp
  • T to C, chromosome 4 at 115,433,981 bp
  • C to A, chromosome 4 at 118,614,975 bp
  • A to G, chromosome 4 at 134,323,038 bp
  • A to T, chromosome 5 at 9,421,620 bp
  • A to T, chromosome 5 at 34,499,668 bp
  • G to T, chromosome 5 at 49,972,062 bp
  • A to G, chromosome 5 at 69,340,976 bp
  • T to C, chromosome 5 at 87,081,581 bp
  • A to G, chromosome 5 at 92,347,803 bp
  • T to A, chromosome 5 at 109,158,174 bp
  • T to A, chromosome 5 at 130,231,928 bp
  • T to C, chromosome 5 at 144,822,703 bp
  • T to A, chromosome 6 at 18,008,640 bp
  • G to A, chromosome 6 at 90,336,919 bp
  • T to C, chromosome 6 at 102,273,811 bp
  • T to C, chromosome 7 at 35,708,155 bp
  • T to A, chromosome 7 at 41,156,020 bp
  • A to G, chromosome 7 at 44,471,153 bp
  • C to T, chromosome 7 at 62,380,857 bp
  • T to C, chromosome 7 at 80,891,778 bp
  • G to T, chromosome 7 at 101,402,191 bp
  • A to G, chromosome 7 at 104,265,816 bp
  • A to G, chromosome 7 at 121,917,961 bp
  • A to T, chromosome 7 at 125,667,074 bp
  • A to G, chromosome 8 at 45,805,696 bp
  • T to A, chromosome 8 at 75,059,271 bp
  • AGAACT to A, chromosome 8 at 107,506,399 bp
  • C to T, chromosome 9 at 19,248,581 bp
  • A to G, chromosome 9 at 21,811,846 bp
  • A to G, chromosome 9 at 31,100,164 bp
  • A to G, chromosome 9 at 37,428,120 bp
  • C to A, chromosome 9 at 40,413,337 bp
  • G to T, chromosome 9 at 65,688,861 bp
  • G to A, chromosome 9 at 105,431,587 bp
  • A to T, chromosome 9 at 108,566,011 bp
  • A to G, chromosome 9 at 109,278,691 bp
  • A to G, chromosome 9 at 118,661,337 bp
  • G to T, chromosome 9 at 119,932,822 bp
  • T to A, chromosome 10 at 39,799,885 bp
  • G to A, chromosome 10 at 60,488,542 bp
  • A to G, chromosome 10 at 77,988,720 bp
  • T to G, chromosome 10 at 99,003,201 bp
  • T to A, chromosome 10 at 121,267,620 bp
  • A to T, chromosome 11 at 9,297,971 bp
  • A to G, chromosome 11 at 17,198,281 bp
  • C to T, chromosome 11 at 46,455,017 bp
  • T to A, chromosome 11 at 58,778,805 bp
  • T to C, chromosome 11 at 60,714,636 bp
  • T to C, chromosome 11 at 71,001,640 bp
  • A to T, chromosome 11 at 99,614,527 bp
  • A to G, chromosome 11 at 113,653,966 bp
  • A to G, chromosome 11 at 120,478,505 bp
  • T to A, chromosome 12 at 119,192,118 bp
  • A to T, chromosome 13 at 56,074,321 bp
  • A to G, chromosome 13 at 72,631,466 bp
  • A to T, chromosome 13 at 119,712,151 bp
  • C to T, chromosome 14 at 12,210,682 bp
  • T to G, chromosome 14 at 31,138,201 bp
  • C to A, chromosome 14 at 32,408,987 bp
  • A to T, chromosome 14 at 49,928,639 bp
  • C to T, chromosome 14 at 65,854,148 bp
  • T to G, chromosome 14 at 67,677,811 bp
  • C to A, chromosome 15 at 43,866,952 bp
  • T to A, chromosome 15 at 76,071,875 bp
  • T to C, chromosome 15 at 98,598,767 bp
  • T to A, chromosome 15 at 98,857,548 bp
  • A to G, chromosome 17 at 24,733,456 bp
  • T to C, chromosome 17 at 33,067,688 bp
  • C to A, chromosome 17 at 47,498,211 bp
  • G to T, chromosome 17 at 84,692,049 bp
  • A to G, chromosome 18 at 80,765,922 bp
  • T to C, chromosome 19 at 5,335,909 bp
  • T to A, chromosome 19 at 5,450,182 bp
  • T to A, chromosome 19 at 13,094,803 bp
  • T to A, chromosome 19 at 17,122,173 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1782 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039813-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.