Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR1794Btlr/Mmmh
Stock Number:
039824-MU
Citation ID:
RRID:MMRRC_039824-MU
Other Names:
R1794 (G1), C57BL/6J-MtgxR1794Btlr
Major Collection:

Strain Information

Cntnap2
Name: contactin associated protein-like 2
Synonyms: 5430425M22Rik, Caspr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66797
Homologene: 69159
Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Nlgn3
Name: neuroligin 3
Synonyms: HNL3, A230085M13Rik, NL3, NLG3
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 245537
Homologene: 23133
Rnf220
Name: ring finger protein 220
Synonyms: 5730503K05Rik, 4931406I20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66743
Homologene: 10036
Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
Lrrc59
Name: leucine rich repeat containing 59
Synonyms: C78668
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 98238
Homologene: 10229
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 4,910,572 bp
  • A to T, chromosome 1 at 75,557,308 bp
  • T to A, chromosome 1 at 83,117,829 bp
  • A to G, chromosome 1 at 90,679,093 bp
  • T to A, chromosome 1 at 131,259,218 bp
  • T to C, chromosome 1 at 131,697,068 bp
  • A to G, chromosome 1 at 150,598,285 bp
  • G to A, chromosome 1 at 150,627,152 bp
  • A to G, chromosome 1 at 153,838,194 bp
  • T to C, chromosome 1 at 162,705,959 bp
  • T to C, chromosome 1 at 188,862,809 bp
  • G to T, chromosome 1 at 192,693,906 bp
  • A to G, chromosome 2 at 25,255,994 bp
  • A to G, chromosome 2 at 39,000,729 bp
  • T to C, chromosome 2 at 66,303,720 bp
  • A to G, chromosome 2 at 83,918,009 bp
  • A to G, chromosome 2 at 90,015,020 bp
  • A to G, chromosome 2 at 127,216,736 bp
  • C to T, chromosome 2 at 179,886,842 bp
  • A to G, chromosome 3 at 82,380,221 bp
  • A to G, chromosome 3 at 94,762,557 bp
  • A to G, chromosome 3 at 98,099,547 bp
  • T to A, chromosome 3 at 146,662,797 bp
  • A to G, chromosome 4 at 43,563,302 bp
  • C to T, chromosome 4 at 59,207,798 bp
  • G to T, chromosome 4 at 117,307,568 bp
  • A to G, chromosome 5 at 24,439,328 bp
  • C to A, chromosome 5 at 43,688,252 bp
  • ACAGCAGCAGCAGCAGC to ACAGCAGCAGCAGC, chromosome 5 at 107,359,853 bp
  • A to T, chromosome 5 at 149,630,773 bp
  • T to C, chromosome 6 at 45,991,863 bp
  • T to C, chromosome 6 at 73,024,958 bp
  • G to T, chromosome 6 at 78,372,214 bp
  • A to G, chromosome 6 at 118,429,303 bp
  • A to G, chromosome 7 at 43,945,223 bp
  • A to T, chromosome 7 at 65,323,129 bp
  • T to C, chromosome 7 at 66,711,909 bp
  • G to A, chromosome 7 at 87,001,413 bp
  • T to C, chromosome 7 at 105,771,720 bp
  • A to G, chromosome 7 at 116,140,681 bp
  • G to T, chromosome 7 at 139,238,563 bp
  • C to A, chromosome 7 at 139,238,565 bp
  • T to C, chromosome 8 at 12,915,982 bp
  • T to A, chromosome 8 at 66,386,942 bp
  • T to G, chromosome 8 at 70,131,908 bp
  • A to T, chromosome 9 at 15,997,136 bp
  • A to T, chromosome 9 at 15,997,138 bp
  • T to A, chromosome 9 at 35,777,122 bp
  • A to G, chromosome 9 at 57,539,281 bp
  • A to G, chromosome 9 at 63,482,557 bp
  • A to C, chromosome 9 at 64,317,776 bp
  • G to A, chromosome 9 at 108,965,928 bp
  • A to G, chromosome 9 at 123,190,094 bp
  • T to C, chromosome 9 at 123,215,831 bp
  • T to A, chromosome 10 at 52,124,103 bp
  • A to C, chromosome 10 at 75,725,745 bp
  • G to T, chromosome 10 at 80,643,913 bp
  • C to A, chromosome 10 at 80,835,598 bp
  • T to C, chromosome 10 at 94,298,490 bp
  • T to C, chromosome 11 at 94,638,595 bp
  • T to C, chromosome 11 at 103,197,147 bp
  • T to C, chromosome 11 at 106,567,902 bp
  • G to A, chromosome 12 at 70,043,795 bp
  • C to T, chromosome 13 at 22,524,351 bp
  • T to C, chromosome 13 at 59,742,620 bp
  • A to G, chromosome 14 at 20,471,467 bp
  • A to G, chromosome 14 at 27,397,605 bp
  • G to T, chromosome 14 at 51,989,930 bp
  • G to T, chromosome 14 at 55,785,329 bp
  • A to G, chromosome 15 at 47,603,616 bp
  • G to A, chromosome 15 at 80,389,122 bp
  • T to C, chromosome 15 at 89,387,020 bp
  • C to A, chromosome 16 at 29,321,709 bp
  • A to G, chromosome 16 at 32,274,132 bp
  • T to C, chromosome 16 at 43,986,915 bp
  • T to C, chromosome 16 at 91,578,029 bp
  • G to A, chromosome 17 at 25,742,934 bp
  • T to G, chromosome 17 at 46,433,153 bp
  • A to G, chromosome 17 at 56,511,599 bp
  • A to G, chromosome 18 at 52,528,307 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • T to C, chromosome 18 at 65,991,684 bp
  • T to A, chromosome 18 at 69,657,853 bp
  • G to C, chromosome 19 at 12,934,968 bp
  • A to G, chromosome 19 at 29,299,557 bp
  • A to G, chromosome X at 101,320,033 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1794 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039824-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.