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Strain Name:
C57BL/6J-MtgxR1832Btlr/Mmmh
Stock Number:
039859-MU
Citation ID:
RRID:MMRRC_039859-MU
Other Names:
R1832 (G1), C57BL/6J-MtgxR1832Btlr
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Eif3h
Name: eukaryotic translation initiation factor 3, subunit H
Synonyms: EIF3-gamma, EIF3-P40, 9430017H16Rik, 1110008A16Rik, Eif3s3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68135
VEGA: 15
HGNC: HGNC:3273
Homologene: 2785
Slc25a12
Name: solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Synonyms: B230107K20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 78830
Homologene: 48235
Pdzd2
Name: PDZ domain containing 2
Synonyms: 4930537L06Rik, LOC223364, A930022H17Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Llgl2
Name: LLGL2 scribble cell polarity complex component
Synonyms: 9130006H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217325
HGNC: HGNC:6629
Homologene: 3323
Wwp1
Name: WW domain containing E3 ubiquitin protein ligase 1
Synonyms: SDRP1, Tiul1, AIP5, 8030445B08Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107568
Homologene: 21385
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to C, chromosome 1 at 10,204,890 bp
  • G to A, chromosome 1 at 38,813,276 bp
  • T to A, chromosome 1 at 68,346,534 bp
  • A to T, chromosome 1 at 83,022,747 bp
  • C to T, chromosome 1 at 153,166,187 bp
  • T to A, chromosome 1 at 158,857,316 bp
  • A to G, chromosome 1 at 180,694,731 bp
  • G to T, chromosome 2 at 11,767,400 bp
  • A to G, chromosome 2 at 25,685,139 bp
  • A to G, chromosome 2 at 27,235,569 bp
  • A to T, chromosome 2 at 59,001,899 bp
  • A to G, chromosome 2 at 71,333,710 bp
  • A to T, chromosome 2 at 128,762,212 bp
  • A to G, chromosome 2 at 143,793,269 bp
  • A to T, chromosome 2 at 144,254,822 bp
  • A to G, chromosome 2 at 145,861,171 bp
  • T to A, chromosome 2 at 150,848,418 bp
  • G to A, chromosome 3 at 18,054,975 bp
  • A to G, chromosome 3 at 41,727,111 bp
  • C to T, chromosome 3 at 106,014,596 bp
  • T to A, chromosome 3 at 124,556,860 bp
  • C to T, chromosome 4 at 13,835,628 bp
  • T to C, chromosome 4 at 19,650,197 bp
  • T to G, chromosome 4 at 59,066,441 bp
  • G to A, chromosome 4 at 115,569,731 bp
  • A to T, chromosome 4 at 123,325,092 bp
  • G to A, chromosome 4 at 130,077,057 bp
  • A to G, chromosome 4 at 134,934,592 bp
  • A to G, chromosome 4 at 145,538,210 bp
  • T to A, chromosome 4 at 154,002,546 bp
  • T to A, chromosome 5 at 72,121,938 bp
  • G to A, chromosome 5 at 73,607,426 bp
  • C to T, chromosome 5 at 135,073,740 bp
  • A to T, chromosome 5 at 137,031,299 bp
  • A to T, chromosome 5 at 143,967,179 bp
  • A to C, chromosome 6 at 32,197,826 bp
  • A to G, chromosome 6 at 43,174,900 bp
  • G to T, chromosome 6 at 66,731,796 bp
  • A to T, chromosome 6 at 69,617,293 bp
  • A to G, chromosome 6 at 83,403,645 bp
  • G to A, chromosome 6 at 111,246,161 bp
  • G to T, chromosome 7 at 26,312,210 bp
  • G to A, chromosome 7 at 34,208,236 bp
  • T to A, chromosome 7 at 83,794,735 bp
  • T to A, chromosome 7 at 114,016,785 bp
  • A to G, chromosome 8 at 11,214,644 bp
  • A to G, chromosome 9 at 19,567,196 bp
  • A to C, chromosome 9 at 54,460,949 bp
  • A to T, chromosome 9 at 65,504,489 bp
  • T to C, chromosome 9 at 98,399,468 bp
  • A to G, chromosome 10 at 20,099,560 bp
  • A to T, chromosome 10 at 41,488,236 bp
  • G to T, chromosome 10 at 80,060,605 bp
  • T to C, chromosome 11 at 30,977,568 bp
  • T to C, chromosome 11 at 69,856,928 bp
  • A to T, chromosome 11 at 73,984,493 bp
  • A to T, chromosome 11 at 110,071,451 bp
  • A to G, chromosome 11 at 115,446,793 bp
  • G to T, chromosome 11 at 115,851,100 bp
  • T to C, chromosome 12 at 55,757,967 bp
  • G to A, chromosome 12 at 78,715,506 bp
  • G to A, chromosome 12 at 80,953,672 bp
  • T to C, chromosome 12 at 88,178,448 bp
  • A to G, chromosome 12 at 98,234,240 bp
  • A to G, chromosome 12 at 110,614,059 bp
  • T to A, chromosome 12 at 116,207,743 bp
  • T to A, chromosome 13 at 67,367,363 bp
  • T to A, chromosome 13 at 73,692,950 bp
  • A to G, chromosome 15 at 12,390,048 bp
  • T to C, chromosome 15 at 51,865,436 bp
  • T to C, chromosome 15 at 74,762,766 bp
  • A to T, chromosome 15 at 94,286,344 bp
  • C to A, chromosome 16 at 36,968,856 bp
  • T to A, chromosome 16 at 88,562,858 bp
  • A to G, chromosome 17 at 28,297,110 bp
  • C to A, chromosome 17 at 35,439,699 bp
  • G to A, chromosome 19 at 6,853,532 bp
  • A to G, chromosome 19 at 33,168,495 bp
  • C to T, chromosome 19 at 36,114,978 bp
  • T to A, chromosome 19 at 44,999,017 bp
  • C to T, chromosome X at 48,543,572 bp
  • T to C, chromosome X at 72,998,659 bp
  • C to A, chromosome X at 96,155,623 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1832 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039859-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.