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Strain Name:
C57BL/6J-MtgxR1837Btlr/Mmmh
Stock Number:
039864-MU
Citation ID:
RRID:MMRRC_039864-MU
Other Names:
R1837 (G1), C57BL/6J-MtgxR1837Btlr
Major Collection:

Strain Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Col2a-1, Col2a, Col2, M100856, Rgsc856, Lpk, M100413, Rgsc413
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Kif5, D10Bwg0738e, Khc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Notch3
Name: notch 3
Synonyms: hpbk, N3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18131
HGNC: HGNC:7883
Homologene: 376
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Med1
Name: mediator complex subunit 1
Synonyms: TRAP 220, TRAP220, CRSP210, DRIP205, Pparbp, l11Jus15, PBP
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19014
HGNC: HGNC:9234
Homologene: 21002
Epb41l2
Name: erythrocyte membrane protein band 4.1 like 2
Synonyms: NBL2, 4.1G, D10Ertd398e, Epb4.1l2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13822
VEGA: 10
HGNC: HGNC:3379
Homologene: 37478
Ylpm1
Name: YLP motif containing 1
Synonyms: ZAP, Zap3, A930013E17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56531
Homologene: 87707
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 42,230,687 bp
  • A to G, chromosome 1 at 58,400,118 bp
  • A to G, chromosome 1 at 84,912,399 bp
  • C to A, chromosome 1 at 135,829,706 bp
  • T to A, chromosome 1 at 143,667,657 bp
  • T to C, chromosome 1 at 162,922,810 bp
  • A to T, chromosome 2 at 22,577,592 bp
  • C to T, chromosome 2 at 25,248,396 bp
  • A to G, chromosome 2 at 29,737,426 bp
  • T to A, chromosome 2 at 37,202,102 bp
  • G to A, chromosome 2 at 65,525,864 bp
  • A to T, chromosome 2 at 66,197,762 bp
  • T to C, chromosome 2 at 77,011,665 bp
  • A to T, chromosome 2 at 89,074,832 bp
  • A to C, chromosome 2 at 119,769,885 bp
  • A to T, chromosome 2 at 120,325,397 bp
  • G to T, chromosome 2 at 154,553,042 bp
  • A to G, chromosome 2 at 155,025,010 bp
  • A to T, chromosome 2 at 181,229,289 bp
  • C to G, chromosome 3 at 88,729,170 bp
  • T to C, chromosome 3 at 89,890,272 bp
  • A to G, chromosome 3 at 94,764,565 bp
  • A to T, chromosome 3 at 154,328,055 bp
  • T to C, chromosome 4 at 34,728,813 bp
  • A to G, chromosome 4 at 34,810,264 bp
  • G to T, chromosome 4 at 139,967,070 bp
  • T to A, chromosome 4 at 140,994,332 bp
  • C to T, chromosome 4 at 150,638,459 bp
  • T to C, chromosome 4 at 155,442,004 bp
  • A to T, chromosome 5 at 20,465,827 bp
  • A to T, chromosome 5 at 25,825,159 bp
  • C to T, chromosome 5 at 34,819,023 bp
  • C to T, chromosome 5 at 110,789,381 bp
  • T to A, chromosome 5 at 115,997,864 bp
  • A to G, chromosome 6 at 85,424,177 bp
  • A to G, chromosome 6 at 86,118,558 bp
  • G to A, chromosome 6 at 113,462,579 bp
  • C to T, chromosome 7 at 12,970,229 bp
  • A to T, chromosome 7 at 21,133,366 bp
  • G to A, chromosome 7 at 27,910,356 bp
  • T to A, chromosome 7 at 85,233,678 bp
  • T to A, chromosome 7 at 141,807,086 bp
  • A to G, chromosome 8 at 4,628,590 bp
  • C to G, chromosome 8 at 15,042,629 bp
  • A to G, chromosome 8 at 41,197,413 bp
  • C to A, chromosome 8 at 64,964,340 bp
  • C to A, chromosome 8 at 110,569,625 bp
  • C to A, chromosome 8 at 111,134,734 bp
  • A to T, chromosome 9 at 7,386,409 bp
  • A to T, chromosome 9 at 7,962,349 bp
  • T to A, chromosome 9 at 50,806,315 bp
  • T to C, chromosome 9 at 96,686,995 bp
  • C to A, chromosome 9 at 97,583,540 bp
  • T to G, chromosome 9 at 118,534,594 bp
  • T to G, chromosome 9 at 119,905,416 bp
  • T to C, chromosome 10 at 25,473,064 bp
  • T to C, chromosome 10 at 41,486,132 bp
  • A to G, chromosome 10 at 75,168,100 bp
  • A to G, chromosome 10 at 75,579,294 bp
  • C to T, chromosome 10 at 93,469,175 bp
  • A to G, chromosome 10 at 111,507,231 bp
  • A to G, chromosome 10 at 116,341,626 bp
  • G to A, chromosome 10 at 127,236,815 bp
  • T to C, chromosome 11 at 29,749,802 bp
  • G to A, chromosome 11 at 59,548,916 bp
  • T to C, chromosome 11 at 59,766,745 bp
  • A to T, chromosome 11 at 60,189,398 bp
  • T to A, chromosome 11 at 70,904,658 bp
  • T to C, chromosome 11 at 94,645,961 bp
  • G to T, chromosome 11 at 98,169,412 bp
  • C to A, chromosome 11 at 106,458,957 bp
  • A to T, chromosome 12 at 75,967,660 bp
  • T to C, chromosome 12 at 85,029,333 bp
  • T to G, chromosome 12 at 98,733,626 bp
  • G to A, chromosome 12 at 109,035,323 bp
  • A to T, chromosome 13 at 92,474,131 bp
  • C to T, chromosome 14 at 68,086,626 bp
  • A to G, chromosome 14 at 79,401,833 bp
  • A to G, chromosome 15 at 6,336,476 bp
  • T to A, chromosome 15 at 9,000,858 bp
  • A to T, chromosome 15 at 55,382,495 bp
  • G to A, chromosome 15 at 65,889,680 bp
  • A to G, chromosome 15 at 85,851,563 bp
  • C to T, chromosome 15 at 97,996,641 bp
  • A to G, chromosome 15 at 101,419,582 bp
  • T to A, chromosome 16 at 56,158,516 bp
  • A to T, chromosome 17 at 22,851,273 bp
  • T to A, chromosome 17 at 28,194,993 bp
  • A to T, chromosome 17 at 32,124,322 bp
  • C to T, chromosome 17 at 34,188,109 bp
  • T to C, chromosome 17 at 56,270,799 bp
  • T to C, chromosome 17 at 78,820,751 bp
  • A to G, chromosome 19 at 12,298,376 bp
  • T to A, chromosome 19 at 12,587,452 bp
  • T to C, chromosome 19 at 34,039,216 bp
  • G to A, chromosome 19 at 48,029,139 bp
  • T to C, chromosome 19 at 57,453,029 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039864-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.