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Strain Name:
C57BL/6J-MtgxR1846Btlr/Mmmh
Stock Number:
039871-MU
Citation ID:
RRID:MMRRC_039871-MU
Other Names:
R1846 (G1), C57BL/6J-MtgxR1846Btlr
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Sufu
Name: SUFU negative regulator of hedgehog signaling
Synonyms: Su(Fu), 2810026F04Rik, b2b273Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 24069
Homologene: 9262
Ppp1r17
Name: protein phosphatase 1, regulatory subunit 17
Synonyms: G-substrate, Gsbs
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19051
Homologene: 4849
Anks3
Name: ankyrin repeat and sterile alpha motif domain containing 3
Synonyms: 2700067D09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72615
VEGA: 16
Homologene: 12475
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 1810033J14Rik, D230038D11Rik, 9530077A04Rik, Mll5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Dnmbp
Name: dynamin binding protein
Synonyms: 2410003M15Rik, Tuba, 2410003L07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Anxa4
Name: annexin A4
Synonyms: Anx4, Xanx-4, annexin IV, AIV
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11746
HGNC: HGNC:542
Homologene: 68164
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 53,647,334 bp
  • A to G, chromosome 1 at 88,258,664 bp
  • A to T, chromosome 1 at 92,491,100 bp
  • G to A, chromosome 1 at 129,613,256 bp
  • A to G, chromosome 1 at 152,848,850 bp
  • C to T, chromosome 1 at 176,755,769 bp
  • T to C, chromosome 1 at 182,326,280 bp
  • T to C, chromosome 2 at 3,491,660 bp
  • A to G, chromosome 2 at 76,945,686 bp
  • A to G, chromosome 2 at 89,930,666 bp
  • A to G, chromosome 2 at 127,829,589 bp
  • A to G, chromosome 3 at 38,982,383 bp
  • A to G, chromosome 3 at 88,378,625 bp
  • T to C, chromosome 3 at 89,092,145 bp
  • T to A, chromosome 3 at 106,130,865 bp
  • T to A, chromosome 3 at 127,615,463 bp
  • T to A, chromosome 3 at 135,239,845 bp
  • A to G, chromosome 3 at 138,480,682 bp
  • C to T, chromosome 4 at 55,383,637 bp
  • C to T, chromosome 4 at 104,731,751 bp
  • GCCCC to GCCCCC, chromosome 4 at 134,425,541 bp
  • T to C, chromosome 4 at 137,007,839 bp
  • T to A, chromosome 4 at 140,067,126 bp
  • A to T, chromosome 5 at 8,988,248 bp
  • G to A, chromosome 5 at 23,499,486 bp
  • T to A, chromosome 5 at 34,848,944 bp
  • T to C, chromosome 5 at 65,808,519 bp
  • A to G, chromosome 6 at 42,897,320 bp
  • A to G, chromosome 6 at 55,063,168 bp
  • A to G, chromosome 6 at 56,022,427 bp
  • A to G, chromosome 6 at 57,036,428 bp
  • T to C, chromosome 6 at 71,976,188 bp
  • A to T, chromosome 6 at 81,956,892 bp
  • T to A, chromosome 6 at 86,741,911 bp
  • C to A, chromosome 6 at 91,256,417 bp
  • T to C, chromosome 6 at 99,640,701 bp
  • C to T, chromosome 7 at 4,920,867 bp
  • G to A, chromosome 7 at 12,512,882 bp
  • G to A, chromosome 7 at 42,789,122 bp
  • A to T, chromosome 7 at 46,660,439 bp
  • T to G, chromosome 7 at 122,176,536 bp
  • A to G, chromosome 8 at 11,514,674 bp
  • T to C, chromosome 8 at 61,983,958 bp
  • C to T, chromosome 9 at 36,763,385 bp
  • T to C, chromosome 9 at 36,867,767 bp
  • A to G, chromosome 9 at 108,372,736 bp
  • G to A, chromosome 9 at 108,487,387 bp
  • G to A, chromosome 9 at 120,558,375 bp
  • T to C, chromosome 10 at 27,212,096 bp
  • A to G, chromosome 10 at 75,610,542 bp
  • A to T, chromosome 10 at 79,738,209 bp
  • T to C, chromosome 10 at 103,025,304 bp
  • A to G, chromosome 10 at 127,185,864 bp
  • C to A, chromosome 11 at 100,105,548 bp
  • A to G, chromosome 11 at 115,568,413 bp
  • A to G, chromosome 11 at 120,813,307 bp
  • T to A, chromosome 12 at 40,733,268 bp
  • C to A, chromosome 13 at 24,760,149 bp
  • A to T, chromosome 13 at 27,602,848 bp
  • A to G, chromosome 13 at 46,848,391 bp
  • C to T, chromosome 13 at 91,664,149 bp
  • G to T, chromosome 14 at 49,235,963 bp
  • T to A, chromosome 14 at 50,815,386 bp
  • A to T, chromosome 15 at 94,345,990 bp
  • C to T, chromosome 15 at 101,434,566 bp
  • C to A, chromosome 16 at 3,854,735 bp
  • A to C, chromosome 16 at 4,953,884 bp
  • T to A, chromosome 16 at 32,752,369 bp
  • A to C, chromosome 17 at 23,359,383 bp
  • A to G, chromosome 17 at 30,929,935 bp
  • T to A, chromosome 17 at 46,413,666 bp
  • A to G, chromosome 17 at 46,576,490 bp
  • A to G, chromosome 17 at 71,225,069 bp
  • C to T, chromosome 17 at 88,765,147 bp
  • T to C, chromosome 19 at 12,463,122 bp
  • C to T, chromosome 19 at 18,955,081 bp
  • T to C, chromosome 19 at 28,964,280 bp
  • T to C, chromosome 19 at 43,902,747 bp
  • T to A, chromosome 19 at 46,450,947 bp
  • T to C, chromosome 19 at 47,670,388 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1846 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039871-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.