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Strain Name:
C57BL/6J-MtgxR1862Btlr/Mmmh
Stock Number:
039885-MU
Citation ID:
RRID:MMRRC_039885-MU
Other Names:
R1862 (G1), C57BL/6J-MtgxR1862Btlr
Major Collection:

Strain Information

Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, ZAKI-4, Csp2, Dscr1l1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Mapk1
Name: mitogen-activated protein kinase 1
Synonyms: p42mapk, MAPK2, Prkm1, Erk2, 9030612K14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26413
HGNC: HGNC:6871
Homologene: 37670
Ubap2
Name: ubiquitin-associated protein 2
Synonyms: 1190005K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68926
Homologene: 73649
Prdm5
Name: PR domain containing 5
Synonyms: 6530401I24Rik, E130112L17Rik, PFM2, 4432417F03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70779
HGNC: HGNC:9349
Homologene: 10274
Ticrr
Name: TOPBP1-interacting checkpoint and replication regulator
Synonyms: 5730590G19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77011
Homologene: 67120
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: mDot1, KMT4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Nup93
Name: nucleoporin 93
Synonyms: 2410008G02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71805
Homologene: 40971
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 20,551,020 bp
  • C to T, chromosome 1 at 30,977,379 bp
  • T to C, chromosome 1 at 65,061,974 bp
  • C to T, chromosome 1 at 127,459,969 bp
  • T to A, chromosome 1 at 136,185,988 bp
  • T to C, chromosome 1 at 138,112,227 bp
  • T to A, chromosome 1 at 140,425,330 bp
  • T to A, chromosome 1 at 150,460,669 bp
  • C to T, chromosome 1 at 150,638,900 bp
  • T to A, chromosome 1 at 174,369,452 bp
  • T to C, chromosome 2 at 13,308,561 bp
  • C to T, chromosome 2 at 52,162,187 bp
  • T to C, chromosome 2 at 61,649,912 bp
  • T to A, chromosome 2 at 62,787,754 bp
  • C to A, chromosome 2 at 70,679,464 bp
  • T to C, chromosome 2 at 92,424,566 bp
  • G to T, chromosome 2 at 122,746,150 bp
  • T to A, chromosome 2 at 126,597,933 bp
  • T to C, chromosome 2 at 145,919,726 bp
  • T to C, chromosome 3 at 64,134,521 bp
  • T to C, chromosome 3 at 86,773,203 bp
  • A to T, chromosome 3 at 98,162,113 bp
  • T to A, chromosome 3 at 131,583,184 bp
  • C to T, chromosome 4 at 12,155,717 bp
  • A to G, chromosome 4 at 41,221,607 bp
  • T to A, chromosome 4 at 46,548,797 bp
  • G to A, chromosome 4 at 130,092,782 bp
  • A to G, chromosome 4 at 156,237,708 bp
  • T to C, chromosome 5 at 23,524,150 bp
  • T to A, chromosome 5 at 92,419,567 bp
  • T to C, chromosome 5 at 113,614,407 bp
  • T to C, chromosome 5 at 123,147,613 bp
  • T to C, chromosome 6 at 21,851,023 bp
  • T to C, chromosome 6 at 48,491,006 bp
  • G to A, chromosome 6 at 55,174,883 bp
  • G to A, chromosome 6 at 60,402,105 bp
  • A to G, chromosome 6 at 65,928,032 bp
  • G to A, chromosome 6 at 71,909,203 bp
  • A to G, chromosome 6 at 83,749,852 bp
  • T to C, chromosome 6 at 120,757,941 bp
  • C to T, chromosome 6 at 129,123,008 bp
  • T to A, chromosome 6 at 141,250,353 bp
  • G to T, chromosome 6 at 141,487,513 bp
  • T to C, chromosome 6 at 142,003,423 bp
  • T to A, chromosome 6 at 149,144,151 bp
  • C to T, chromosome 7 at 10,173,406 bp
  • C to A, chromosome 7 at 29,845,010 bp
  • T to C, chromosome 7 at 30,316,883 bp
  • T to C, chromosome 7 at 79,695,207 bp
  • A to G, chromosome 7 at 90,382,915 bp
  • A to G, chromosome 7 at 104,411,198 bp
  • T to A, chromosome 7 at 106,603,447 bp
  • A to C, chromosome 7 at 108,066,725 bp
  • T to C, chromosome 7 at 135,699,361 bp
  • G to A, chromosome 7 at 140,228,184 bp
  • C to T, chromosome 8 at 11,226,439 bp
  • C to T, chromosome 8 at 21,929,986 bp
  • A to T, chromosome 8 at 84,415,930 bp
  • T to C, chromosome 8 at 94,306,102 bp
  • T to A, chromosome 8 at 99,190,394 bp
  • T to C, chromosome 8 at 105,050,169 bp
  • A to T, chromosome 9 at 15,007,428 bp
  • T to C, chromosome 9 at 18,444,921 bp
  • T to A, chromosome 9 at 37,746,968 bp
  • A to G, chromosome 9 at 53,376,248 bp
  • T to A, chromosome 9 at 89,085,571 bp
  • T to A, chromosome 9 at 120,957,510 bp
  • A to G, chromosome 10 at 78,584,124 bp
  • G to T, chromosome 10 at 80,783,539 bp
  • A to G, chromosome 11 at 34,404,274 bp
  • C to T, chromosome 11 at 59,758,221 bp
  • A to T, chromosome 11 at 80,663,048 bp
  • A to G, chromosome 11 at 87,567,235 bp
  • T to C, chromosome 11 at 96,704,157 bp
  • G to A, chromosome 11 at 98,842,209 bp
  • T to C, chromosome 11 at 116,106,137 bp
  • A to G, chromosome 11 at 121,054,942 bp
  • T to C, chromosome 12 at 81,918,732 bp
  • A to T, chromosome 13 at 67,491,188 bp
  • T to A, chromosome 14 at 8,241,416 bp
  • A to G, chromosome 14 at 21,686,689 bp
  • A to G, chromosome 14 at 26,697,398 bp
  • A to T, chromosome 14 at 26,709,257 bp
  • A to C, chromosome 14 at 65,026,413 bp
  • A to G, chromosome 14 at 65,270,803 bp
  • A to C, chromosome 14 at 74,742,074 bp
  • G to A, chromosome 15 at 78,780,514 bp
  • T to A, chromosome 16 at 17,026,429 bp
  • A to G, chromosome 16 at 90,766,769 bp
  • A to G, chromosome 17 at 38,275,344 bp
  • A to G, chromosome 17 at 38,419,439 bp
  • A to T, chromosome 17 at 44,037,089 bp
  • A to G, chromosome 17 at 58,922,583 bp
  • A to G, chromosome 17 at 78,622,746 bp
  • A to G, chromosome 18 at 10,079,207 bp
  • T to C, chromosome 18 at 84,095,318 bp
  • A to G, chromosome 19 at 33,784,692 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1862 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039885-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.