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Strain Name:
C57BL/6J-MtgxR1899Btlr/Mmmh
Stock Number:
039919-MU
Citation ID:
RRID:MMRRC_039919-MU
Other Names:
R1899 (G1), C57BL/6J-MtgxR1899Btlr
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: transcytosis associated protein p115, TAP, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Tlx3
Name: T cell leukemia, homeobox 3
Synonyms: Tlx1l2, Rnx, Hox11l2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27140
Homologene: 23181
P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms: P2X7 receptor, P2X7R, P2X(7)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18439
HGNC: HGNC:8537
Homologene: 1925
Spen
Name: spen family transcription repressor
Synonyms: Mint
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56381
Homologene: 124461
Cdk19
Name: cyclin dependent kinase 19
Synonyms: 2700084L06Rik, Cdc2l6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 78334
VEGA: 10
Homologene: 22862
Yes1
Name: YES proto-oncogene 1, Src family tyrosine kinase
Synonyms: Yes
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22612
Homologene: 55900
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 11,162,366 bp
  • G to T, chromosome 1 at 22,428,474 bp
  • A to G, chromosome 1 at 37,438,799 bp
  • A to T, chromosome 1 at 58,946,336 bp
  • G to A, chromosome 1 at 88,235,376 bp
  • A to T, chromosome 1 at 135,400,146 bp
  • A to T, chromosome 1 at 150,657,451 bp
  • A to T, chromosome 1 at 184,069,180 bp
  • T to C, chromosome 2 at 55,437,244 bp
  • T to C, chromosome 2 at 62,345,050 bp
  • A to T, chromosome 2 at 86,085,720 bp
  • T to C, chromosome 2 at 89,296,670 bp
  • A to G, chromosome 2 at 118,927,015 bp
  • T to A, chromosome 3 at 40,964,084 bp
  • T to C, chromosome 3 at 68,918,513 bp
  • A to G, chromosome 3 at 89,180,260 bp
  • A to T, chromosome 3 at 89,520,455 bp
  • A to T, chromosome 3 at 158,031,580 bp
  • T to C, chromosome 4 at 32,643,647 bp
  • C to T, chromosome 4 at 43,361,804 bp
  • T to C, chromosome 4 at 102,968,337 bp
  • T to G, chromosome 4 at 109,246,293 bp
  • T to C, chromosome 4 at 141,470,343 bp
  • C to G, chromosome 5 at 25,198,532 bp
  • G to A, chromosome 5 at 25,829,538 bp
  • G to A, chromosome 5 at 29,473,957 bp
  • A to T, chromosome 5 at 32,645,051 bp
  • A to G, chromosome 5 at 34,907,085 bp
  • C to A, chromosome 5 at 43,277,587 bp
  • T to A, chromosome 5 at 92,201,192 bp
  • A to C, chromosome 5 at 104,938,199 bp
  • T to A, chromosome 5 at 109,736,798 bp
  • A to G, chromosome 5 at 122,673,736 bp
  • A to G, chromosome 5 at 148,509,280 bp
  • T to A, chromosome 6 at 9,247,622 bp
  • C to A, chromosome 6 at 28,125,895 bp
  • A to G, chromosome 6 at 71,780,797 bp
  • A to G, chromosome 6 at 82,918,029 bp
  • A to G, chromosome 6 at 106,675,813 bp
  • A to G, chromosome 6 at 115,969,363 bp
  • T to C, chromosome 7 at 15,987,751 bp
  • T to A, chromosome 7 at 18,478,425 bp
  • A to G, chromosome 7 at 23,404,797 bp
  • C to T, chromosome 7 at 26,839,033 bp
  • T to A, chromosome 7 at 44,841,633 bp
  • T to C, chromosome 7 at 99,582,297 bp
  • T to C, chromosome 7 at 122,183,842 bp
  • T to C, chromosome 7 at 127,235,654 bp
  • T to G, chromosome 7 at 130,624,202 bp
  • G to T, chromosome 8 at 3,603,922 bp
  • C to A, chromosome 8 at 4,249,600 bp
  • G to A, chromosome 8 at 22,252,318 bp
  • T to G, chromosome 8 at 111,165,674 bp
  • T to C, chromosome 8 at 122,482,645 bp
  • T to C, chromosome 8 at 122,489,566 bp
  • A to G, chromosome 9 at 21,006,831 bp
  • A to T, chromosome 9 at 22,251,549 bp
  • A to T, chromosome 9 at 37,404,070 bp
  • A to T, chromosome 9 at 44,798,216 bp
  • A to T, chromosome 9 at 50,995,674 bp
  • T to C, chromosome 9 at 78,461,517 bp
  • A to T, chromosome 9 at 107,550,037 bp
  • A to G, chromosome 9 at 108,978,888 bp
  • T to C, chromosome 9 at 111,022,845 bp
  • A to G, chromosome 9 at 121,748,866 bp
  • T to A, chromosome 10 at 40,479,780 bp
  • A to G, chromosome 10 at 90,260,756 bp
  • G to T, chromosome 11 at 3,531,326 bp
  • T to C, chromosome 11 at 33,203,072 bp
  • T to C, chromosome 11 at 34,294,286 bp
  • T to G, chromosome 11 at 46,150,231 bp
  • A to G, chromosome 11 at 50,266,130 bp
  • T to C, chromosome 11 at 55,262,178 bp
  • A to G, chromosome 11 at 60,185,920 bp
  • A to G, chromosome 11 at 60,203,486 bp
  • A to T, chromosome 11 at 69,743,946 bp
  • G to T, chromosome 11 at 69,801,453 bp
  • C to T, chromosome 11 at 72,754,407 bp
  • A to T, chromosome 11 at 78,205,021 bp
  • A to G, chromosome 11 at 94,570,720 bp
  • G to T, chromosome 11 at 109,937,918 bp
  • C to T, chromosome 11 at 113,838,646 bp
  • C to T, chromosome 12 at 28,746,985 bp
  • A to T, chromosome 12 at 53,141,852 bp
  • T to C, chromosome 12 at 69,346,378 bp
  • A to T, chromosome 13 at 11,591,336 bp
  • A to G, chromosome 13 at 119,767,025 bp
  • C to A, chromosome 14 at 24,148,300 bp
  • T to G, chromosome 14 at 35,810,132 bp
  • A to T, chromosome 14 at 64,079,390 bp
  • A to T, chromosome 14 at 123,316,126 bp
  • A to G, chromosome 15 at 80,391,642 bp
  • A to T, chromosome 15 at 80,692,080 bp
  • A to G, chromosome 15 at 89,101,090 bp
  • A to G, chromosome 16 at 10,542,518 bp
  • A to G, chromosome 16 at 13,147,787 bp
  • T to C, chromosome 17 at 25,229,460 bp
  • T to C, chromosome 18 at 38,258,342 bp
  • T to C, chromosome 19 at 3,978,662 bp
  • C to A, chromosome 19 at 6,245,067 bp
  • T to C, chromosome 19 at 12,298,343 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1899 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039919-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.