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Strain Name:
C57BL/6J-MtgxR1903Btlr/Mmmh
Stock Number:
039923-MU
Citation ID:
RRID:MMRRC_039923-MU
Other Names:
R1903 (G1), C57BL/6J-MtgxR1903Btlr
Major Collection:

Strain Information

Dct
Name: dopachrome tautomerase
Synonyms: tyrosinase-related protein-2, TRP-2, Tyrp-2, Tyrp2, TRP2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13190
VEGA: 14
HGNC: HGNC:2709
Homologene: 1447
Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Lamb1
Name: laminin B1
Synonyms: Lamb-1, C81607, C80098, D130003D08Rik, Lamb1-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Htr4
Name: 5 hydroxytryptamine (serotonin) receptor 4
Synonyms: 5-HT4L, 5-HT4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15562
VEGA: 18
HGNC: HGNC:5299
Homologene: 20243
Htr3a
Name: 5-hydroxytryptamine (serotonin) receptor 3A
Synonyms: 5-HT3 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15561
VEGA: 9
HGNC: HGNC:5297
Homologene: 671
Crhr1
Name: corticotropin releasing hormone receptor 1
Synonyms: CRFR1, CRF-R1alpha, CRF 1 receptor, CRF1R
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12921
Homologene: 20920
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,535,478 bp
  • A to T, chromosome 1 at 58,918,855 bp
  • T to C, chromosome 1 at 60,082,024 bp
  • T to C, chromosome 1 at 82,289,461 bp
  • A to G, chromosome 1 at 87,982,056 bp
  • A to T, chromosome 1 at 172,484,560 bp
  • A to G, chromosome 1 at 179,702,523 bp
  • G to T, chromosome 1 at 180,588,670 bp
  • G to C, chromosome 1 at 185,221,902 bp
  • A to G, chromosome 2 at 28,839,956 bp
  • T to A, chromosome 2 at 69,434,994 bp
  • C to T, chromosome 2 at 86,275,846 bp
  • T to C, chromosome 2 at 120,526,848 bp
  • T to A, chromosome 2 at 122,295,351 bp
  • C to A, chromosome 2 at 158,495,563 bp
  • A to T, chromosome 2 at 178,420,581 bp
  • A to G, chromosome 3 at 49,755,447 bp
  • A to G, chromosome 3 at 65,946,911 bp
  • C to T, chromosome 3 at 85,998,307 bp
  • T to C, chromosome 3 at 88,368,761 bp
  • C to T, chromosome 3 at 98,328,039 bp
  • T to A, chromosome 3 at 103,337,444 bp
  • A to T, chromosome 3 at 152,248,181 bp
  • T to C, chromosome 4 at 6,208,889 bp
  • T to A, chromosome 4 at 6,688,948 bp
  • A to T, chromosome 4 at 19,839,254 bp
  • T to C, chromosome 4 at 21,910,466 bp
  • A to G, chromosome 4 at 43,357,063 bp
  • T to C, chromosome 4 at 43,446,998 bp
  • T to A, chromosome 4 at 48,402,824 bp
  • C to T, chromosome 4 at 49,529,511 bp
  • G to T, chromosome 4 at 64,000,062 bp
  • A to T, chromosome 4 at 70,403,554 bp
  • T to A, chromosome 4 at 73,403,438 bp
  • T to C, chromosome 4 at 101,463,636 bp
  • A to G, chromosome 4 at 118,160,399 bp
  • T to C, chromosome 4 at 118,622,066 bp
  • T to A, chromosome 4 at 132,721,352 bp
  • A to G, chromosome 4 at 134,078,856 bp
  • A to T, chromosome 4 at 135,750,908 bp
  • C to A, chromosome 4 at 138,192,060 bp
  • A to G, chromosome 4 at 155,949,026 bp
  • C to T, chromosome 5 at 8,134,525 bp
  • A to G, chromosome 5 at 21,665,272 bp
  • A to T, chromosome 5 at 24,493,013 bp
  • A to T, chromosome 5 at 32,291,238 bp
  • CTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCT to CTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCT, chromosome 5 at 32,910,407 bp
  • A to T, chromosome 5 at 34,676,187 bp
  • T to A, chromosome 5 at 65,166,987 bp
  • T to G, chromosome 5 at 72,616,725 bp
  • T to A, chromosome 5 at 104,518,330 bp
  • A to C, chromosome 5 at 107,369,295 bp
  • G to A, chromosome 5 at 112,692,758 bp
  • A to T, chromosome 5 at 114,165,734 bp
  • A to T, chromosome 5 at 135,133,568 bp
  • G to A, chromosome 5 at 142,815,140 bp
  • T to G, chromosome 5 at 144,816,053 bp
  • A to G, chromosome 6 at 71,967,914 bp
  • T to C, chromosome 7 at 13,835,975 bp
  • T to A, chromosome 7 at 20,023,257 bp
  • A to G, chromosome 7 at 27,428,281 bp
  • A to G, chromosome 7 at 44,581,736 bp
  • C to T, chromosome 7 at 79,838,256 bp
  • T to C, chromosome 7 at 142,296,347 bp
  • T to C, chromosome 7 at 143,703,181 bp
  • A to G, chromosome 8 at 78,251,732 bp
  • T to A, chromosome 8 at 85,086,822 bp
  • T to C, chromosome 8 at 95,743,121 bp
  • T to A, chromosome 8 at 105,675,988 bp
  • T to A, chromosome 8 at 106,912,350 bp
  • A to G, chromosome 8 at 110,682,534 bp
  • A to T, chromosome 9 at 8,120,747 bp
  • A to T, chromosome 9 at 18,988,896 bp
  • A to G, chromosome 9 at 22,076,519 bp
  • C to G, chromosome 9 at 46,221,089 bp
  • T to C, chromosome 9 at 48,319,606 bp
  • A to T, chromosome 9 at 48,906,381 bp
  • A to G, chromosome 9 at 53,931,590 bp
  • A to C, chromosome 9 at 57,258,352 bp
  • T to C, chromosome 9 at 67,894,052 bp
  • C to T, chromosome 9 at 72,616,811 bp
  • A to T, chromosome 9 at 88,799,029 bp
  • A to C, chromosome 9 at 104,228,937 bp
  • A to C, chromosome 9 at 106,693,717 bp
  • G to A, chromosome 9 at 108,040,996 bp
  • T to A, chromosome 10 at 7,623,780 bp
  • T to A, chromosome 10 at 11,183,797 bp
  • T to C, chromosome 10 at 19,008,189 bp
  • A to G, chromosome 10 at 24,778,789 bp
  • A to C, chromosome 10 at 27,188,399 bp
  • T to A, chromosome 10 at 63,123,397 bp
  • G to T, chromosome 10 at 82,702,558 bp
  • G to T, chromosome 10 at 105,190,108 bp
  • T to G, chromosome 10 at 128,308,368 bp
  • C to T, chromosome 11 at 9,466,411 bp
  • G to T, chromosome 11 at 29,461,788 bp
  • T to A, chromosome 11 at 69,656,444 bp
  • T to A, chromosome 11 at 70,437,982 bp
  • T to C, chromosome 11 at 99,075,575 bp
  • T to C, chromosome 11 at 101,575,152 bp
  • A to G, chromosome 11 at 104,169,849 bp
  • G to T, chromosome 11 at 116,227,028 bp
  • T to G, chromosome 12 at 31,329,210 bp
  • T to C, chromosome 12 at 38,166,777 bp
  • T to G, chromosome 12 at 69,959,275 bp
  • A to C, chromosome 12 at 83,958,447 bp
  • T to C, chromosome 12 at 84,830,105 bp
  • T to A, chromosome 12 at 102,131,617 bp
  • C to T, chromosome 12 at 110,947,912 bp
  • C to T, chromosome 12 at 112,175,540 bp
  • G to T, chromosome 12 at 116,241,790 bp
  • A to G, chromosome 13 at 41,032,518 bp
  • T to C, chromosome 13 at 59,718,068 bp
  • C to A, chromosome 13 at 98,686,416 bp
  • T to A, chromosome 13 at 104,174,897 bp
  • A to T, chromosome 13 at 110,084,210 bp
  • C to T, chromosome 14 at 13,829,657 bp
  • T to C, chromosome 14 at 31,319,759 bp
  • T to C, chromosome 14 at 47,074,128 bp
  • T to G, chromosome 14 at 52,372,717 bp
  • T to C, chromosome 14 at 118,034,278 bp
  • G to A, chromosome 15 at 100,716,118 bp
  • G to T, chromosome 16 at 20,604,832 bp
  • T to A, chromosome 16 at 20,645,172 bp
  • C to T, chromosome 16 at 32,498,413 bp
  • A to C, chromosome 16 at 44,422,374 bp
  • A to T, chromosome 16 at 59,362,163 bp
  • A to G, chromosome 16 at 72,960,204 bp
  • A to T, chromosome 17 at 26,087,413 bp
  • C to T, chromosome 17 at 35,873,846 bp
  • A to T, chromosome 17 at 80,413,587 bp
  • A to T, chromosome 18 at 20,095,988 bp
  • T to G, chromosome 18 at 62,428,122 bp
  • G to A, chromosome 18 at 84,947,827 bp
  • A to T, chromosome 19 at 11,896,549 bp
  • C to T, chromosome 19 at 32,016,674 bp
  • T to C, chromosome X at 36,000,212 bp
  • G to A, chromosome X at 47,849,963 bp
  • G to A, chromosome X at 108,664,264 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1903 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039923-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.