Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR1932Btlr/Mmmh
Stock Number:
039950-MU
Citation ID:
RRID:MMRRC_039950-MU
Other Names:
R1932 (G1), C57BL/6J-MtgxR1932Btlr
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195
Vcan
Name: versican
Synonyms: PG-M, hdf, heart defect, 5430420N07Rik, Cspg2, DPEAAE
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Herc3
Name: hect domain and RLD 3
Synonyms: 5730409F18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73998
HGNC: HGNC:4876
Homologene: 57095
Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: Kv1.6, MK1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Sox10
Name: SRY (sex determining region Y)-box 10
Synonyms: Sox21, gt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20665
VEGA: 15
Homologene: 5055
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,967,400 bp
  • A to C, chromosome 1 at 58,991,105 bp
  • G to T, chromosome 1 at 78,468,035 bp
  • A to G, chromosome 1 at 91,388,469 bp
  • G to T, chromosome 1 at 128,294,161 bp
  • C to T, chromosome 1 at 133,131,625 bp
  • T to A, chromosome 1 at 138,842,009 bp
  • A to G, chromosome 1 at 150,421,663 bp
  • T to A, chromosome 1 at 174,028,414 bp
  • T to C, chromosome 1 at 174,050,678 bp
  • A to G, chromosome 2 at 64,912,802 bp
  • A to T, chromosome 2 at 66,676,102 bp
  • T to A, chromosome 2 at 69,953,476 bp
  • C to A, chromosome 2 at 74,695,685 bp
  • G to A, chromosome 2 at 91,497,355 bp
  • T to C, chromosome 2 at 118,448,486 bp
  • C to T, chromosome 2 at 120,531,681 bp
  • T to A, chromosome 2 at 124,659,886 bp
  • T to A, chromosome 2 at 127,095,148 bp
  • T to C, chromosome 2 at 158,376,826 bp
  • A to G, chromosome 2 at 178,381,957 bp
  • G to A, chromosome 2 at 179,932,029 bp
  • T to C, chromosome 3 at 10,205,233 bp
  • A to C, chromosome 3 at 70,028,104 bp
  • A to T, chromosome 3 at 96,719,298 bp
  • C to A, chromosome 3 at 129,280,990 bp
  • T to C, chromosome 3 at 135,544,740 bp
  • T to C, chromosome 4 at 40,176,499 bp
  • A to T, chromosome 4 at 63,993,025 bp
  • C to T, chromosome 4 at 99,911,018 bp
  • T to A, chromosome 4 at 115,611,277 bp
  • A to G, chromosome 4 at 123,452,037 bp
  • G to A, chromosome 4 at 127,946,858 bp
  • A to T, chromosome 4 at 134,544,618 bp
  • A to G, chromosome 5 at 38,319,976 bp
  • A to G, chromosome 5 at 113,754,223 bp
  • A to G, chromosome 6 at 6,042,264 bp
  • A to T, chromosome 6 at 24,955,011 bp
  • A to G, chromosome 6 at 58,876,793 bp
  • T to C, chromosome 6 at 83,404,379 bp
  • T to A, chromosome 6 at 91,394,548 bp
  • C to T, chromosome 6 at 120,897,255 bp
  • G to T, chromosome 6 at 126,738,488 bp
  • C to T, chromosome 7 at 3,109,066 bp
  • T to A, chromosome 7 at 8,367,982 bp
  • G to A, chromosome 7 at 24,352,633 bp
  • A to G, chromosome 7 at 27,307,766 bp
  • C to T, chromosome 7 at 29,198,143 bp
  • G to T, chromosome 7 at 73,454,445 bp
  • A to T, chromosome 7 at 98,716,838 bp
  • T to C, chromosome 7 at 105,765,902 bp
  • C to T, chromosome 7 at 110,279,263 bp
  • T to C, chromosome 7 at 119,454,232 bp
  • T to A, chromosome 7 at 119,968,087 bp
  • C to T, chromosome 7 at 126,384,992 bp
  • T to C, chromosome 7 at 131,242,016 bp
  • A to T, chromosome 8 at 21,326,849 bp
  • A to G, chromosome 8 at 45,796,352 bp
  • A to T, chromosome 8 at 69,102,807 bp
  • A to G, chromosome 9 at 30,956,512 bp
  • T to A, chromosome 9 at 44,279,394 bp
  • T to A, chromosome 9 at 56,619,650 bp
  • C to T, chromosome 9 at 83,577,631 bp
  • T to A, chromosome 9 at 108,999,169 bp
  • A to G, chromosome 10 at 61,222,016 bp
  • G to A, chromosome 10 at 77,941,158 bp
  • A to G, chromosome 10 at 128,816,792 bp
  • G to T, chromosome 11 at 4,146,549 bp
  • T to C, chromosome 11 at 70,608,428 bp
  • A to T, chromosome 11 at 71,182,138 bp
  • T to C, chromosome 11 at 96,320,041 bp
  • T to A, chromosome 11 at 102,195,872 bp
  • T to C, chromosome 11 at 104,335,097 bp
  • T to C, chromosome 11 at 106,004,610 bp
  • T to G, chromosome 11 at 108,192,149 bp
  • G to T, chromosome 12 at 75,716,179 bp
  • T to A, chromosome 13 at 12,435,185 bp
  • A to G, chromosome 13 at 32,127,997 bp
  • T to A, chromosome 13 at 61,253,615 bp
  • T to C, chromosome 13 at 89,705,534 bp
  • T to A, chromosome 13 at 90,883,687 bp
  • T to A, chromosome 13 at 97,141,967 bp
  • T to C, chromosome 13 at 106,978,091 bp
  • G to A, chromosome 15 at 71,870,140 bp
  • A to T, chromosome 15 at 76,624,597 bp
  • A to T, chromosome 15 at 78,491,777 bp
  • G to A, chromosome 15 at 79,163,281 bp
  • G to A, chromosome 15 at 79,261,389 bp
  • T to A, chromosome 15 at 94,404,010 bp
  • G to A, chromosome 15 at 98,650,718 bp
  • T to A, chromosome 16 at 10,241,703 bp
  • T to A, chromosome 16 at 22,806,554 bp
  • G to A, chromosome 16 at 37,062,304 bp
  • G to A, chromosome 16 at 45,684,593 bp
  • T to C, chromosome 16 at 59,623,119 bp
  • C to T, chromosome 17 at 3,514,725 bp
  • T to A, chromosome 17 at 20,040,769 bp
  • C to A, chromosome 17 at 33,781,275 bp
  • C to A, chromosome 17 at 46,549,986 bp
  • T to A, chromosome 17 at 75,313,034 bp
  • C to T, chromosome 18 at 3,299,284 bp
  • C to T, chromosome 18 at 37,309,541 bp
  • G to A, chromosome 18 at 60,916,651 bp
  • T to C, chromosome 18 at 80,969,753 bp
  • C to T, chromosome 19 at 3,610,131 bp
  • C to T, chromosome 19 at 4,166,571 bp
  • G to T, chromosome 19 at 8,737,947 bp
  • T to C, chromosome 19 at 26,630,658 bp
  • C to T, chromosome 19 at 43,746,785 bp
  • A to G, chromosome 19 at 47,267,508 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R1932 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
039950-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.